Solubility of norfloxacin and ofloxacin in supercritical carbon dioxide

Chim, Rita; Marceneiro, Sofia; Braga, Mara E.M.; Dias, Ana M.A.; Sousa, Hermínio C. de

doi:10.1016/j.fluid.2012.06.023

Cited by 29 publications

(13 citation statements)

References 36 publications

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“…The highest deviations (13.7% and 13.4%) were observed at lower pressure (10 MPa) and when comparing with data measured by Pauchon et al [41] and Wagner et al [43], respectively. These results, together with solubility data previously published for different solid solutes at different temperature, pressure and solubility ranges [27][28][29][30][31][32][33][34][35] and using the same apparatus and experimental procedures, confirm the accuracy of the measurements reported in the present work.…”

Section: Resultssupporting

confidence: 91%

“…Experimental equilibrium solubility data of ATRA in scCO 2 were measured using a static analytical method and accordingly to the methodology previously described in the literature [27][28][29][30][31][32][33][34][35]. Briefly, it consists in a high pressure stainless steel equilibrium cell with sapphire windows connected to a six-port sampling valve, which is further connected to a known volume sampling loop followed by a glass trap (collector for the scCO 2 solubilized solute with known volume) and a stainless steel balloon (with calibrated volume to quantify the solvent).…”

Section: Solubility Determination 221 Apparatus and Proceduresmentioning

confidence: 99%

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Solubility of all-trans retinoic acid in supercritical carbon dioxide

Rosa

Marceneiro

Braga

et al. 2015

The Journal of Supercritical Fluids

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All-trans retinoic acid (ATRA) is a derivative of retinol (or vitamin A) presenting similar benefits but considerable lower adverse toxicity, mainly in cases of high or long-term therapeutic doses. ATRA showed to be effective in the treatment and/or chemoprevention of several epithelial and hematological malignancies and diverse dermatological and eye diseases however, its low solubility in aqueous media and photosensitivity hinder its wider usage by the conventional administration methods. Supercritical fluids technologies are being widely used to enhance the in vivo bioactivity of this type of drugs both by improving their dissolution rate (using particle size reduction processes) and/or by controlling their release into the media after incorporation into solid polymeric/inorganic matrices (using supercritical impregnation/foaming processes). In both cases the solubility of the drug in the supercritical fluid (usually scCO 2) is required for process optimization purposes. Therefore, in this work the solubility of ATRA in scCO 2 was measured at different isotherms (308.2, 318.2 and 328.2 K) and pressures that ranged from 10 up to 30 MPa using a static analytical method. Solubility data were correlated using three commonly used density-based models, namely the Bartle, Chrastil and Méndez-Santiago-Teja models. The solubility of ATRA in scCO 2 was found to be between 1.52 × 10 −6 and 1.84 × 10 −5 in terms of ATRA mole fraction and between 7.50 × 10 −3 and 1.07 × 10 −1 in terms of amount of solid solute per unit of volume of scCO 2. Fairly good correlation agreement was obtained with all the applied models being the lowest deviations obtained with the Chrastil model. ATRA particles obtained after scCO 2 processing (dissolution in scCO 2 followed by re-precipitation) were characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transform infrared (FTIR) and in vitro dissolution studies. The results showed that the processed particles maintained their chemical structure and presented enhanced dissolution in aqueous media (PBS:ethanol, 80:20, v/v) when compared with commercial (non-processed) ATRA.

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Section: Resultssupporting

confidence: 91%

Section: Solubility Determination 221 Apparatus and Proceduresmentioning

confidence: 99%

Solubility of all-trans retinoic acid in supercritical carbon dioxide

Rosa

Marceneiro

Braga

et al. 2015

The Journal of Supercritical Fluids

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“…By introducing the reference solubility into the compressed gas model and calculating the fugacity coefficient of the solute using the CS–VDW EoS, the complicated properties of the solute can be avoided in solubility correlation. − This method was used to correlate the solubilities of gatifloxacin, enrofloxacin, ciprofloxacin in SC–CO 2 and the results are shown in Figure and Table . The solubilities of ofloxacin and norfloxacin reported in ref were also correlated using this modified compressed gas model. The correlation results in Table show that for the same medicine, the model parameters at different temperatures are close.…”

Section: Results and Discussionmentioning

confidence: 99%

“… a Ref . b . c Measured using the differential scanning calorimetry method (DSC) under atmospheric pressure (101.441 kPa). Standard uncertainties u are u ( T m ) = 1.42 K, u (Δ fus H ) = 1.83 kJ·mol –1 , u ( p atm ) = 0.077 kPa.…”

Section: Methodsmentioning

confidence: 99%

Solubility Determination and Correlation of Gatifloxacin, Enrofloxacin, and Ciprofloxacin in Supercritical CO₂

Shi

Feng

et al. 2017

J. Chem. Eng. Data

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The solubilities of gatifloxacin, enrofloxacin, ciprofloxacin in SC–CO2 were determined by the dynamic method under pressures of 12–36 MPa and temperature of 313, 323, and 333 K. The consistency of the resulting solubility data was verified by the Mendez-Santiago and Teja model, Chrastil model, Bartle model, and K-J model and these models give comparable AARDs (between 6.70% and 13.51%). The compressed gas model and modified expanded liquid model were also used to correlate the resulting solubilities of the three fluoroquinolone drugs. By introducing the reference solubility and calculating the fugacity coefficient of the solute using the Carnahan–Starling-VDW hard sphere equation of state (CS-VDW EoS), the compressed gas model gives the AARDs between 0.86% and 23.65%. The intrinsic proximity of the model parameters in this model is also confirmed for the structurally similar fluoroquinolone drugs. This intrinsic proximity can be used in mutual solubility prediction between the fluoroquinolone drugs once the reference solubilities were known. The modified expanded liquid model gives the AARDs between 10.88% and 16.65% in solubility correlation. However, the predictive capability of the modified expanded liquid model based on the group contribution method needs to be improved further.

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“…Among various types of supercritical fluids, CO 2 is the most frequently used one because it is nontoxic, nonflammable, and non‐explosive, and has mild critical properties. In recent years, many studies have been conducted to determine the solubility of various drugs in supercritical CO 2 (SC‐CO 2 ) .…”

Section: Introductionmentioning

confidence: 99%

Effect of Stearic Acid as a Co‐solvent on the Solubility Enhancement of Aspirin in Supercritical CO₂

2019

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The solubility of aspirin in supercritical CO 2 (SC-CO 2 ) with stearic acid as a co-solvent was measured at various pressures and temperatures. The experimental data were obtained by a static method. Stearic acid had a significant effect on the enhancement of solubility, as the aspirin solubility increased by up to 16 times. Further, the effect of stearic acid on the solubility enhancement of aspirin was compared with that of other co-solvents. Different semi-empirical models from the literature were applied for correlating the experimental data, proving good agreement with the experimental data. The model of Sung and Shim exhibited the lowest deviation from the obtained data. The results of the solubility test can be employed to produce aspirin-based pharmaceuticals using supercritical fluid technology (SFT).

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Solubility of norfloxacin and ofloxacin in supercritical carbon dioxide

Cited by 29 publications

References 36 publications

Solubility of all-trans retinoic acid in supercritical carbon dioxide

Solubility of all-trans retinoic acid in supercritical carbon dioxide

Solubility Determination and Correlation of Gatifloxacin, Enrofloxacin, and Ciprofloxacin in Supercritical CO₂

Effect of Stearic Acid as a Co‐solvent on the Solubility Enhancement of Aspirin in Supercritical CO₂

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Solubility of norfloxacin and ofloxacin in supercritical carbon dioxide

Cited by 29 publications

References 36 publications

Solubility of all-trans retinoic acid in supercritical carbon dioxide

Solubility of all-trans retinoic acid in supercritical carbon dioxide

Solubility Determination and Correlation of Gatifloxacin, Enrofloxacin, and Ciprofloxacin in Supercritical CO2

Effect of Stearic Acid as a Co‐solvent on the Solubility Enhancement of Aspirin in Supercritical CO2

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Solubility Determination and Correlation of Gatifloxacin, Enrofloxacin, and Ciprofloxacin in Supercritical CO₂

Effect of Stearic Acid as a Co‐solvent on the Solubility Enhancement of Aspirin in Supercritical CO₂