Skin lightening is a basic requirement for people who live in tropical countries such as Asia. Asian cultures consider bright skin as a beautiful standard. The growth of skin lightening products in Asia is increasing rapidly. 1 Most skin lightening products contained drug that have side effects on long-term use. Side effects that arise are dermatological reactions such as burning, itching, irritation and causing the effects of dependence. These side effects are related to the safety of the product. 2 Lightening active ingredients that are considered unsafe such as mercury and hydroquinone because mercury can cause nephrotoxicity, due to the accumulation of heavy metals contained in the material. 2 Turbinaria conoides is one of brown macroalgae which can be found in the oceans of Indonesia. 3 T. conoides has bioactive compound such as carotenoid, laminarin, alginate, fucoidan and mannitol. 3 Fraction of T. conoides has reported by Karthik (2016), contained phloroglucinol (0,49 mg TAE/g). 4 Phloroglucinol is a multifunctional phenolic derivative that only can be found in brown algae. Phloroglucinol showed various activities