Solubility of sodium diclofenac in different solvents

The application of ATR-FTIR spectroscopy and multivariate data analysis to study drug crystallisation in the stratum corneum

“…The solubility of DF Na in DMSO is consistent with the concentration estimated from the solubility graph of DF Na (~ 165 mg/g) reported by Žilnik et al [26]. 13 …”

IUPAC-NIST Solubility Data Series. 102. Solubility of Nonsteroidal Anti-inflammatory Drugs (NSAIDs) in Neat Organic Solvents and Organic Solvent Mixtures

“…There have been several studies 81,100,164,[191][192][193][194][195] involving the solubility of sodium diclofenac in organic solvents. Most notably, Bustamante et al 164 measured the mole fraction solubility of sodium diclofenac in 22 different organic solvents, including two saturated hydrocarbons (heptane and cyclohexane), one aromatic hydrocarbon (benzene), one alkyl alkanoate (ethyl ethanoate), one dialkyl ether (1,1′-oxybisethane) and one cyclic ether (1,4-dioxane), two chloroalkanes (trichloromethane and 1,2-dichloroethane) and one chlorinated aromatic hydrocarbon (chlorobenzene), seven alcohols (methanol, ethanol, 1-pentanol, 1-octanol, 1,2-ethanediol, 1,2-propanediol, and 1,2,3-propanetriol), one alkanone (propanone) and one aromatic ketone (acetophenone), and four miscellaneous organic solvents (ethanoic acid, propanoic acid, formamide, and N,N-dimethylformamide) at 298 K and atmospheric pressure.…”

“…There have been three studies 89,191,195 examining the solubility of sodium diclofenac as a function of temperature. Zilnik et al 191 determined the solubility of sodium diclofenac in ethyl ethanoate, propanone and dimethyl sulfoxide at several temperatures between 293 and 313 K. The experimental solidliquid equilibrium data were modeled using expressions based on the Nonrandom Two Liquid (NRTL) and UNIQUAC models.…”

“…Zilnik et al 191 determined the solubility of sodium diclofenac in ethyl ethanoate, propanone and dimethyl sulfoxide at several temperatures between 293 and 313 K. The experimental solidliquid equilibrium data were modeled using expressions based on the Nonrandom Two Liquid (NRTL) and UNIQUAC models. The authors found that both solution models provided a reasonably accurate mathematical description of the observed solubility behavior of sodium diclofenac in the three solvents, with average relative deviations between the backcalculated and measured data on the order of 2% or less.…”

Development of sericin/alginate particles by ionic gelation technique for the controlled release of diclofenac sodium

“…The heteroatoms N, O, Cl, and Na in the molecular structure of diclofenac causes high polarizability of the molecule and hence specific interactions with solvents that strongly affect the drug solubility. Because of the presence of the NH group that can act either as proton donor or proton acceptor toward the solvents and the presence of the carboxylic group, the drug possesses a Lewis acid–base character . It has a short half‐life in the body, about 1–2 h, being administered 3–4 times a day to maintain therapeutic drug‐blood level .…”