Solubility of some inhaled glucocorticoids in supercritical carbon dioxide

Vatanara, Alireza; Najafabadi, Abdolhossein Rouholamini; Khajeh, Mostafa; Yamini, Yadollah

doi:10.1016/j.supflu.2004.05.002

Cited by 7 publications

(6 citation statements)

References 22 publications

(25 reference statements)

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“…For example, at a pressure of 243 bar, enhancement of the temperature from 75 to 85°C, changed the solubility of BDP in SC-CO 2 from 51.8×10 -3 (g Solute /L CO2 ) to 50.8×10 -3 (g Solute /L CO2 ). 10 The same results have been reported for Digitoxin, 11 Titanocendicholoride, 12 and benzoic acid. 13 However for salicylic acid 14 and ibuprofen 15 larger particles at lower pre-expansion temperature had been found.…”

Section: Effect Of Pre-expansion Temperaturesupporting

confidence: 71%

See 1 more Smart Citation

Formation and Characterization of Beclomethasone Dipropionate Nanoparticles Using Rapid Expansion of Supercritical Solution

Hosseinpour¹,

Vatanara²,

Zarghami³

2015

Adv Pharm Bull

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The smallest MPS of BDP obtained from the RESS process was 65 nm that revealed a significant size reduction from its original MPS of 9 μm. Moreover, a slight change was observed for precipitated particles of BDP into spherical form while the original particles were irregular in shape. RESS process showed as a promising method for production of BDP nanoparticles that may results in improvement of drug's physicochemical properties.

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Section: Effect Of Pre-expansion Temperaturesupporting

confidence: 71%

“…9 The solubility of BDP in the supercritical CO 2 (SC-CO 2 ) over different pressure and temperature ranges was reported previously. 10 In this study, the effect of RESS parameters such as extraction pressure, pre-expansion temperature, and weight fraction of co-solvent on the size and distribution of BDP particles were investigated.…”

Section: Introductionmentioning

confidence: 99%

Formation and Characterization of Beclomethasone Dipropionate Nanoparticles Using Rapid Expansion of Supercritical Solution

Hosseinpour¹,

Vatanara²,

Zarghami³

2015

Adv Pharm Bull

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“…To our knowledge experimental data for the solubility of DXMT in scCO 2 is presented for the first time in this work. There is a previous work in the literature that presented the solubility of other glucocorticoids (beclomethasone dipropionate, fluticasone proprionate, budesonide) in scCO 2 , however for a higher temperature [between (338 and 358) K] and pressure [(21.3 and 38.5) MPa] ranges and using a methodology similar to the one used in this work . Authors justified the necessity to use that higher pressure and temperature conditions due to the low solubility of the compounds that varied between 5.93·10 –6 (at 338 K and 21.3 MPa) and 3.36·10 –5 (at 358 K and 38.5 MPa).…”

Section: Resultsmentioning

confidence: 99%

“…There is a previous work in the literature that presented the solubility of other glucocorticoids (beclomethasone dipropionate, fluticasone proprionate, budesonide) in scCO 2 , however for a higher temperature [between (338 and 358) K] and pressure [ (21.3 and 38.5) MPa] ranges and using a methodology similar to the one used in this work. 39 Authors justified the necessity to use that higher pressure and temperature conditions due to the low solubility of the compounds that varied between 5.93•10 −6 (at 338 K and 21.3 MPa) and 3.36•10 −5 (at 358 K and 38.5 MPa). In the present work, some modifications were introduced in the experimental methodology as well as in the drug quantification method, as previously described, in order to accurately measure the solubility of DXMT at mild experimental conditions.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Solubility of Dexamethasone in Supercritical Carbon Dioxide

et al. 2012

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Dexamethasone (DXMT) is a glucocorticoid that belongs to an important class of synthetic steroid hormones with potential to treat chronic immune and inflammatory diseases. In this work, the solid solubility of dexamethasone in supercritical carbon dioxide (scCO2) was measured using a static method. Experimental data were measured at (308.2, 318.2, and 328.2) K in the pressure range from (15.1 to 35.7) MPa. The solubility in scCO2 was found to be low and between (1.25·10–6 or 9.1·10–3) kg·m–3 (at 308.2 K and 15.1 MPa) and (2.81·10–6 or 22.0·10–3) kg·m–3 (at 328.2 K and 34.8 MPa) in terms of mole fraction or mass of drug per volume of solvent, respectively. Experimental data were correlated using semiempirical density based models (Méndez-Santiago–Teja, Bartle, and Chrastil). Obtained average absolute relative deviation [AARD (%)] values were lower than 13 %.

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“…Solubility cross-over regions of medroxyprogesterone and cyproterone acetate were reported about 22 MPa and above 30 MPa, respectively (Asghari-Khiavi et al, 2004). Vatanara et al (2005) reported that beclomethasone dipropionate and budesonide had the same cross-over region at 24.3 MPa. Khimeche et al (2007) observed that the solubility cross-over pressures for 4,4-diaminodiphenylmethane (DADPM) and 1,5-naphtalediamine (1,5 NDA) were around 15.2 and 14.5 MPa respectively.…”

Section: Solubility Determinationmentioning

confidence: 95%