Solubility of some novel cyanopyridine derivatives

Abstract

Abbreviations: DMF, dimethyl formamide; DMSO, dimethyl sulfoxide; RMSD, root-mean-square deviations; RD, relative deviations; RAD, relative average deviations Abstract Some new cyano pyridine derivatives have been synthesized and their characterization was done by IR, 1H NMR and mass spectral data. The solubility of these synthesized compounds has been studied in dimethyl formamide and dimethyl sulphoxide at different temperatures at atmospheric pressure.

Physicochemical Properties of a Bi-aromatic Heterocyclic-Azo/BSA Hybrid System at the Air–Water Interface

“… 1 − 5 N-Heterocyclic compound polarizability favors their solubility in many polar synthetic and natural solvents. 6 , 7 The majority of N-heterocyclic compounds having different physical properties are soluble in water. 8 − 10 Moderate solubility of benzimidazole in water allows its use in synthesis of useful drugs.…”

“…N-Heterocyclic back bones are found in imidazole, pyridine, and benzimidazole derivatives, which are actively used in pharmaceutical fields. − N-Heterocyclic compound polarizability favors their solubility in many polar synthetic and natural solvents. , The majority of N-heterocyclic compounds having different physical properties are soluble in water. − Moderate solubility of benzimidazole in water allows its use in synthesis of useful drugs. Azo-heterocyclic compounds have been tremendously developed in the last few decades having valuable activity in biological fields. − But the amount of literature on mixed N-heterocyclic azo compounds is limited in literature. − In these azo-biheterocyclic compounds, the presence of a −NN–CN- azo–imine, functional group between two N-heterocyclic substances promotes their activity. , Azo-benzimidazole compounds are of significant importance due to their use as potent antibacterial, antitubercular, antitumor, and antifungal substances. , Azo-benzimidazole also shows some particular physical properties, such as nonlinear optical and thermal properties. , The presence of active N-hydrogen in the imidazole part of benzimidazole leads to a tendency to form H-bonds with several amino acids of different protein moieties.…”