Solubility of Tris(hydroxymethyl)aminomethane in Methanol + 1-Propanol Mixtures at Various Temperatures

Abstract

Solubility of tris(hydroxymethyl)aminomethane (TRIS) in various mass fractions of binary solvent mixtures of methanol and 1-propanol [at (293.2, 298.2, 303.2, 308.2, and 313.2) K] was measured and mathematically represented using the Jouyban-Acree model. The correlated mole fraction solubilities are in good agreement with the corresponding experimental values with an overall mean percentage deviation of 1.7%. Densities of saturated solutions of TRIS in pure methanol and 1-propanol at various temperatures were measured and employed to predict the density of saturated solutions of TRIS in their binary solvent mixtures. ■ INTRODUCTIONBuffer solutions composed of binary solvents are used as mobile phases and/or background electrolytes in analytical separation methods such as liquid chromatography or capillary electrophoresis, where the low solubility of the buffering agents at higher concentrations of the low polar solvent may cause practical problems. Using nonaqueous based mobile phases and/or running buffers, suitable analytical methods enable analyzing highly hydrophobic analytes or compounds that exhibit restricted stability in aqueous media. 1 Addition of the second organic solvent to aqueous solutions alters the solubility of the analyte, the resolution of analytes, or determine other relevant analytical parameters like pK a values, partition coefficients or electrophoretic mobilities. 2,3 In addition to these applications, the solubility data of TRIS is also required in solubilization/crystallization studies. The common method for obtaining a solute's solubility is the trial and error approach which is a time-consuming and costly method. Any predictive tool to estimate the best solvent composition for solubilization/ crystallization of Tris(hydroxymethyl)aminomethane (TRIS) is obviously in demand.TRIS (chemical abstract service number 77-86-1) is a common buffering agent in chemical and biochemical areas. It is used in nonaqueous solvents for analytical and separation purposes. Available solubility data of TRIS in various solvent mixtures is reviewed in a recent publication 4 along with reporting TRIS solubility in water + methanol (MeOH) 2 and water + 1-propanol (1-PrOH) 5 mixtures at 293.2 to 313.2 K. A quick survey on the published pharmaceutical analysis methods showed that MeOH + 1-PrOH has been used in some developed analytical methods. 6 To continue our systematic investigations on the solubility of solutes in solvent mixtures, the solubility of TRIS in MeOH + 1-PrOH mixtures at different temperatures [(293.2, 298.2, 303.2, 308.2, and 313.2) K] was measured using a validated labmade setup. 4,7 The trained version of a mathematical model is presented to provide a predictive tool for calculation of the solubility of TRIS at any composition of MeOH + 1-PrOH solvent mixture and at any temperature in the range mentioned.■ EXPERIMENTAL SECTION Materials. TRIS (with the stated purity of 0.999 in mass fraction) and MeOH (mass fraction purity of 0.999) were purchased from Merck (Germany). 1-PrOH (ma...

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