Solubility parameter of an N-isopropylacrylamide gel

Yagi, Yasuhiko; Inomata, Hiroshi; Saito, Shozaburo

doi:10.1021/ma00037a034

Cited by 59 publications

(44 citation statements)

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“…The observed difference in these swelling ratios can be predicted by comparing the Hildebrand solubility [36] parameters (d) of PNIPAAm [d gel ¼ 11.5 (cal Á cm À3 ) 1/2 ], ethanol [d EtOH ¼ 12.7 (cal Á cm À3 ) 1/2 ], and water [d water ¼ 23.4 (cal Á cm À3 ) 1/2 ]. [37] A stronger swelling of the PNIPAAm-1 gel layers in ethanol is suggested by the similarity of the Hildebrand solubility of ethanol to that of PNIPAAm.…”

Section: Refractive Index Gradientsmentioning

confidence: 99%

Optical Characterization of Co‐Nonsolvency Effects in Thin Responsive PNIPAAm‐Based Gel Layers Exposed to Ethanol/Water Mixtures

Anac

Aulasevich

Junk

et al. 2010

Macro Chemistry & Physics

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Surface‐attached, photo‐crosslinked gel films of a N‐isopropylacrylamide copolymer were investigated in ethanol/water mixtures using a combination of surface plasmon resonance/optical waveguide spectroscopy with reversed WKB analysis. The solvent quality of the pure good solvents drops in their mixture and this co‐nonsolvency effect shifts the transition temperature (Tc) in the µm‐thin gel films from 32.8 °C in pure water to 29.7 °C with only 0.25 vol.‐% ethanol. Between 20 and 70% ethanol and >10 °C (the practical temperature limit) the layers existed only in the collapsed state. A reentrant Tc of 40.2 °C was found at 70% ethanol while at higher ethanol volume fraction no Tc could be recorded.magnified image

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Section: Refractive Index Gradientsmentioning

confidence: 99%

Optical Characterization of Co‐Nonsolvency Effects in Thin Responsive PNIPAAm‐Based Gel Layers Exposed to Ethanol/Water Mixtures

Anac

Aulasevich

Junk

et al. 2010

Macro Chemistry & Physics

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“…8 As can be seen from Table 1, the solubility parameter of PEBA-2533 membrane was 19.51 (J/cm 3 ) 1/2 , which was close to that of aniline (21.1). 42,43 In addition, aniline is only partially miscible with water. This means that the interaction between aniline and water molecules is relatively weak, which may also favor the sorption of aniline onto the membrane.…”

Section: Membrane Swelling and Preferential Sorptionmentioning

confidence: 99%

Efficient recovery of high‐purity aniline from aqueous solutions using pervaporation‐fractional condensation system

Zhang

Hao

et al. 2015

AIChE Journal

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Selective recovery of valuable minor component with high-purity form from dilute aqueous solution is an interesting issue in the area of organophilic pervaporation. High-purity aniline was recovered with a high production rate from dilute aqueous solution by a pervaporation-fractional condensation (PVFC) coupling system. The effects of downstream pressure and temperature (the first condenser) on the performance of PVFC system were investigated based on experimental measurements and Aspen simulations. Sorption and desorption experiments demonstrated that the sorption selectivity of poly(ether block amide) (PEBA-2533) membrane to aniline was extremely high, indicating excellent pervaporation performance for aniline/water solutions. The perfect integration of high-performance PEBA-2533 membrane with the fractional condensation process yielded high production rate of 1222.5 g/(m 2 h) as well as high recovery efficiency (86.5%) for recovering high-purity aniline in the first condenser when feed concentration and temperature were 1 wt % and 808C, respectively. V C 2015 American Institute of Chemical Engineers AIChE J, 61: [4445][4446][4447][4448][4449][4450][4451][4452][4453][4454][4455] 2015

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“…Below the LCST, water hydrates PNIPAAm chains. Above the transition temperature, the polymer becomes hydrophobic, resulting in a dramatic phase separation [25][26][27] and formation of a solid gel without the use of toxic monomers or crosslinkers. However, PNIPAAm homopolymers exhibit poor elastic properties and hold little water at physiological temperature due to hydrophobicity 28 .…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Thermogelling Poly(N-isopropylacrylamide)-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering

Christiani

Toomer

Sheehan

et al. 2016

JoVE

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Injectable biomaterials are defined as implantable materials that can be introduced into the body as a liquid and solidify in situ. Such materials offer the clinical advantages of being implanted minimally invasively and easily forming space-filling solids in irregularly shaped defects. Injectable biomaterials have been widely investigated as scaffolds for tissue engineering. However, for the repair of certain load-bearing areas in the body, such as the intervertebral disc, scaffolds should possess adhesive properties. This will minimize the risk of dislocation during motion and ensure intimate contact with the surrounding tissue, providing adequate transmission of forces. Here, we describe the preparation and characterization of a scaffold composed of thermally sensitive poly(N-isopropylacrylamide)-graft-chondroitin sulfate (PNIPAAMg-CS) and alginate microparticles. The PNIPAAm-g-CS copolymer forms a viscous solution in water at RT, into which alginate particles are suspended to enhance adhesion. Above the lower critical solution temperature (LCST), around 30 °C, the copolymer forms a solid gel around the microparticles. We have adapted standard biomaterials characterization procedures to take into account the reversible phase transition of PNIPAAm-g-CS. Results indicate that the incorporation of 50 or 75 mg/ml alginate particles into 5% (w/v) PNIPAAm-g-CS solutions quadruple the adhesive tensile strength of PNIPAAm-gCS alone (p<0.05). The incorporation of alginate microparticles also significantly increases swelling capacity of PNIPAAm-g-CS (p<0.05), helping to maintain a space-filling gel within tissue defects. Finally, results of the in vitro toxicology assay kit, 2,3-bis-(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide (XTT) and Live/Dead viability assay indicate that the adhesive is capable of supporting the survival and proliferation of encapsulated Human Embryonic Kidney (HEK) 293 cells over 5 days. Video LinkThe video component of this article can be found at

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Solubility parameter of an N-isopropylacrylamide gel

Cited by 59 publications

References 0 publications

Optical Characterization of Co‐Nonsolvency Effects in Thin Responsive PNIPAAm‐Based Gel Layers Exposed to Ethanol/Water Mixtures

Optical Characterization of Co‐Nonsolvency Effects in Thin Responsive PNIPAAm‐Based Gel Layers Exposed to Ethanol/Water Mixtures

Efficient recovery of high‐purity aniline from aqueous solutions using pervaporation‐fractional condensation system

Synthesis of Thermogelling Poly(N-isopropylacrylamide)-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering

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