Solubility Prediction of Drugs in Water-Polyethylene Glycol 400 Mixtures Using Jouyban-Acree Model

Abstract

is statistically significant (pϽ0.0005). The proposed method produces acceptable residual distribution and the probability of solubility prediction with residual log of solubility Ͻ0.5 unit is 0.86. The applicability of the proposed method could be extended for predicting the solubility of drugs in water-PEG 400 mixtures at various temperatures. The impact of various log P values computed using different software is also studied and the results of ANOVA revealed that there are no significant differences between the accuracy of the predicted solubilities employing various log P values.

Solubility of Acetaminophen and Ibuprofen in Binary and Ternary Mixtures of Polyethylene Glycol 600, Ethanol and Water

“…1 was trained using experimental solubility of drugs in PEG 400-water mixtures and the obtained model was 30) : (5) In deriving Eq. 5, we assumed that the extents of solute-solvent interactions are the same for all solutes in PEG 400-water mixtures.…”

Solubility of Pioglitazone Hydrochloride in Binary and Ternary Mixtures of Water, Propylene Glycol, and Polyethylene Glycols 200, 400, and 600 at 298.2 K

“…Using the model constants (J 0 , J 1 , and J 2 ) listed in Table IV, it is possible to predict the solubility of PGZ-HCl in binary mixtures of solvents 1 and 2 at all composition ranges and by employing the solubility in the mono-solvents at other temperatures, one can extend this prediction method for other temperatures as shown in previous works (20,21). As noted in INTRODUCTION, using generally trained version of the model for PEG 400+water mixtures and employing C (23) where the MPD range varied between 3.5% and 269.3% and the overall MPD for predicted solubilities in this work is less than that of the reported value in our previous paper, i.e., 39.8% (23). Table V lists the experimental solubility of PGZ-HCl in ternary solvent mixtures of PG+PEGs+water.…”

Solubility of Pioglitazone Hydrochloride in Binary Mixtures of Polyethylene Glycol 400 with Ethanol, Propylene Glycol, N-Methyl-2-pyrrolidone, and Water at 25 .DEG.C

“…C 1,T Sat and C 2,T Sat values as has been shown in previous papers. 22,23) The numerical values of the model constants (J i terms) are not temperature dependent, at least at the temperature range of 20-40°C and we could use the trained models to predict the solubility at other temperatures. In an earlier paper, the model trained using solubility data at 25°C was used to predict the solubility at 30°C 22) and in another report, the trained model using the solubility data at 30°C, the solubilities at 25°C were pre- Table 3.…”

“…22,23) The numerical values of the model constants (J i terms) are not temperature dependent, at least at the temperature range of 20-40°C and we could use the trained models to predict the solubility at other temperatures. In an earlier paper, the model trained using solubility data at 25°C was used to predict the solubility at 30°C 22) and in another report, the trained model using the solubility data at 30°C, the solubilities at 25°C were pre- Table 3. The minimum MRD of 1.5% is observed for NMPϩPEG 400 mixtures, the maximum value of 7.4% for waterϩPEG 400 mixtures and the overall MRD of 4.3% is obtained revealing that the model is able to accurately represent the solubility of PGZ-HCl in both aqueous and non-aqueous solvent mixtures.…”

“…In order to provide more generalized predictive models, the trained versions of the Jouyban-Acree model were presented for the mixed solvent systems with suitable available data sets. For the binary solvents studied in this work, the trained version of the model for PEG 400-water mixtures is available as 22) : (5) in which the minus sign of the coefficient of (w 1 Ϫw 2 ) in the original paper is replaced with ϩ, since we defined water as solvent 1 and PEG 400 as solvent 2, whereas in the original paper, PEG 400 and water were defined as solvents 1 and 2. By including experimental values of C 1,T Sat and C 2,T Sat in Eq.…”