Solubility, the Main Concern for Poorly Water-soluble Drugs: Techniques and Alternatives

Abstract

The most important variable that affects a drug's bioavailability is its aqueous solubility. One of the biggest issues facing the pharmaceutical business is improving water solubility, which is the key to improving therapeutic efficacy. During the first screening procedure, over 50% of recently created medications are discovered to be insoluble or weakly soluble. The solubility of the medicine can be increased using a variety of techniques. The method entails both chemical and physical drug modifications. Any medicine that is absorbed must be present at the absorption site in the form of a solution. Poorly soluble medications can be made more soluble using a variety of approaches, like physical and chemical alterations to the drug and other strategies. Using a surfactant, complexation, and so on are examples of solid dispersion. The choice of a solubility-improving technology is influenced by pharmacological properties, absorption sites, and the requirements for the dosage form. In order to serve as a quick reference, this study attempted to gather information on various solubility improvement methods and organize it systematically.

Influence of Intermolecular Interactions on Crystallite Size in Crystalline Solid Dispersions

“…The Biopharmaceutical Classification System (BCS) concept was first introduced by LENNE et al in 1995 [1]. BCS Class II and IV drugs constitute up to 90% of drug candidates currently in development, accounting for approximately 60% of poorly soluble drugs on the global market [2,3]. Furthermore, the trend of poorly soluble drugs in marketed products is not expected to be alleviated significantly in the near future.…”