Solubilization and co-solubilization of carbamazepine and nifedipine in mixed micellar systems: insights from surface tension, electronic absorption, fluorescence and HPLC measurements

Abstract

We present single and simultaneous solubilization of carabamezipine and nifedipine in mixed micelles.

Interactions and Solubilization of Poorly Soluble Drugs in Aerosol‐OT Micelles

“…In this context, the binding constants of drugs to micelles can be quantitatively determined using the simple mathematical model known as the Benesi–Hildebrand equation based on the Beer–Lambert law valid in the high micelle concentration region (Benesi and Hildebrand, ). In spite of many reports on the interactions between drugs and conventional surfactants in the literature (Azum et al, , ; Cai et al, ; Chauhan et al, ; Enache and Volanschi, ; Hanif et al, ; Hossain and Hoque, ; Kabir‐ud‐Din et al, ; Kaushal et al, ; Khan et al, ; Khan and Shah, ; Lazaro et al, ; Mukhija and Kishore, ; Naqvi et al, ; Noori et al, ; Rub et al, , , ; Sharma and Jani, ; Ullah et al, ), there is limited number of studies that combine spectroscopy with surface tension measurements or conductometry for the understanding of the mechanism of these types of interactions (Ali et al, ; Ansari et al, ; Gokturk et al, ; Kabir‐ud‐Din et al, , ; Maswal et al, ; Rub et al, ). Previously, we reported a study on the binding characteristics of poorly soluble drugs sulfamethoxazole (SMX) and trimethoprim (TMP) in the presence of sodium dodecyl sulfate (SDS) and Triton X‐100 (TX‐100) micelles employing spectroscopy and surface tension measurements.…”

An investigation of Pluronic P123–sodium cholate mixed system: micellization, gelation and encapsulation behavior

“…[40][41][42] Bile salt micelles have been utilized as solubilizing media for various hydrophobic moieties with their solubilizing efficiency modulated by mixed micellization with other conventional surfactants. 43 However, little emphasis has been given to the mixed micellization of bile salts with Pluronics. Very recently, Roy et al 44 investigated the role of NaTc (sodium taurocholate) and NaDc (sodium deoxycholate) on the self-assembled architecture of P123 micelles.…”

Mixed Micelles of Surface Active Ionic Liquid (SAIL)–Octylphenol Ethoxylate: A Novel Reaction Medium for Selective Oxidation of Toluene to Benzaldehyde

“…MSR is expressed by Eq. ) (Maswal et al, 2015) where S T and S M are the apparent solubilities of the solute in water and micelles, respectively. C is the concentration of surfactant taken and CMC its critical micelle concentration.…”

“…MSR depicts the number of moles of solute that can be solubilized per mole of surfactant while K M is the distribution of solute between water and micelles in terms of moles.MSR is expressed by Eq. (1)(Maswal et al, 2015)…”