Solubilization and determination of solution thermodynamic properties of itraconazole in different solvents at different temperatures

Jagdale, Sachin; Nawale, Rajesh B.

doi:10.1080/03639045.2019.1602138

Cited by 6 publications

(2 citation statements)

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“…Thus, the solubility data of solid solutes in monosolvents could be useful in purification, crystallization, drug development processes, and formulation development. 19,20 Temperaturedependent solubility data of poorly water-soluble drugs in mono or mixed solvents are extremely useful in various research areas in pharmaceutical industries. 21−24 formamide (DMF), N,N-dimethyl acetamide (DMA), dimethyl sulfoxide (DMSO), N-methyl-2-pyrrolidone (NMP), ethylene glycol (EG), propylene glycol (PG), 1,4-butanediol (BDOH), glycerin, polyethylene glycol-200 (PEG-200), PEG-400, PEG-600, and water have not been reported in the literature.…”

Section: ■ Introductionmentioning

confidence: 99%

“…A perusal of the structure of SAT indicates that the molecule is highly aromatic and the functional groups may not contribute much to the aqueous solubility. − Moreover, unfortunately the information about its physicochemical properties such as solubility is not yet complete. Thus, the solubility data of solid solutes in monosolvents could be useful in purification, crystallization, drug development processes, and formulation development. , Temperature-dependent solubility data of poorly water-soluble drugs in mono or mixed solvents are extremely useful in various research areas in pharmaceutical industries. − Temperature-dependent solubility data of SAT in monosolvents such as methanol (MeOH), ethanol (EtOH), 1-propanol (1-PrOH), 2-propanol (2-PrOH), formamide, 1,4-dioxane, N,N -dimethyl formamide (DMF), N,N -dimethyl acetamide (DMA), dimethyl sulfoxide (DMSO), N -methyl-2-pyrrolidone (NMP), ethylene glycol (EG), propylene glycol (PG), 1,4-butanediol (BDOH), glycerin, polyethylene glycol-200 (PEG-200), PEG-400, PEG-600, and water have not been reported in the literature.…”

Section: Introductionmentioning

confidence: 99%

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Thermodynamic Modeling and Solubility Study of Satranidazole in Different Monosolvents at Different Temperatures

Rathi¹,

Kale

Jouyban

2021

J. Chem. Eng. Data

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The solubility study of drugs in aqueous and organic solvents has practical importance in pharmaceutical industries. In this research work, the solubilities of satranidazole (SAT) were determined in 18 monosolvents, namely, methanol (MeOH), ethanol (EtOH), 1-propanol (1-PrOH), 2-propanol (2-PrOH), formamide, 1,4-dioxane, N,N-dimethyl formamide (DMF), N,N-dimethyl acetamide (DMA), dimethyl sulfoxide (DMSO), N-methyl-2-pyrrolidone (NMP), ethylene glycol (EG), propylene glycol (PG), 1,4-butanediol (BDOH), glycerin, polyethylene glycol-200 (PEG-200), PEG-400, PEG-600, and water, at five different temperatures (T = 293.2–313.2 K) and atmospheric pressure (p = 0.1 MPa). Experimental solubilities expressed in the molar fraction of SAT were correlated well with thermodynamic models including van’t Hoff model, Apelblat model, Buchowski–Ksiazczak model, and polynomial empirical model. The molar fraction solubility of SAT was recorded highest in NMP (7.963 × 10–2 at T = 293.2 K) followed by DMSO, formamide, DMF, DMA, PEG-600, PEG-400, PEG-200, 1,4-dioxane, PG, EG, BDOH, glycerin, MeOH, EtOH, 1-PrOH, 2-PrOH, and water as expected over the entire temperature range investigated.

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Section: ■ Introductionmentioning

confidence: 99%