Solubilization of drugs by cationic surfactants micelles: Conductivity and 1H NMR experiments

Farías, Tania; Menorval, L. C. De; Zając, Jerzy; Rivera, A.

doi:10.1016/j.colsurfa.2009.04.022

Cited by 88 publications

(39 citation statements)

References 33 publications

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“…Table 1 declares that GA-1500 derivative has the lowest maximum surface excess value. On contrarily, decreasing the hydrophilic chain, as represented in case of GA-400 and GA-600 derivatives, increases Γ max to higher values, which is in agreement with the reported data [20,22].…”

Section: Resultssupporting

confidence: 92%

“…The first is the attraction force between surfactants and water molecules via hydrogen bonds which increased by increasing the ethylene glycol units, and the second is repulsion force between phenyl groups and water molecules. The first force increases the tendency of surfactant molecules to locate in the bulk of their solution, while the second increases their presence at the air/water interface [21][22][23]. The micellization of surfactants is the result of the two forces.…”

Section: Resultsmentioning

confidence: 96%

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Synthesis and Surface Activity of Nonionic Surfactants Derived from Gallic Acid

et al. 2014

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A series of nonionic surfactants were synthesized from gallic acid and polyethylene glycols with different molecular weights. Chemical structures of the surfactants were confirmed using elemental analysis, infrared and nuclear magnetic resonance ( 1 H-NMR) spectroscopy. Surface activities of the surfactants in their solutions were determined by surface tension measurements. Increasing the polyethylene glycol chain length increased the surface activity of the surfactants in solutions. Measurements of interfacial tension between surfactants solutions and substrates with different polarity showed that the type of substrates plays functioning role on the interfacial properties. Thermodynamic properties of adsorption and micellization processes showed their tendency towards adsorption at solution interface and micellization in their solutions. Results showed reasonable surface activities compared to conventional nonionic surfactants.

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Section: Resultssupporting

confidence: 92%

Section: Resultsmentioning

confidence: 96%

Synthesis and Surface Activity of Nonionic Surfactants Derived from Gallic Acid

et al. 2014

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“…The CMC was determined from the break point in the c log c plot. The CMC of pure C16Cl is found to be 0.6 mM at 35°C, which is slightly higher than the value reported for the same surfactant at 25°C [21]. Table 1 shows the CMC of the surfactant in the presence of the added electrolytes at 35°C.…”

Section: Effect Of Added Salts On the Cmccontrasting

confidence: 40%

Salt‐Induced Modulation of the Krafft Temperature and Critical Micelle Concentration of Benzyldimethylhexadecylammonium Chloride

Islam

Sharker

Sarker

2015

J Surfact & Detergents

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In this work, the effect of some sodium salts on the Krafft temperature (T K ) and critical micelle concentration (CMC) of benzyldimethylhexadecylammonium chloride (C16Cl) in aqueous solution has been studied. It was observed that the T K can be modulated to lower and higher values and the CMC can be depressed significantly upon the addition of the electrolytes. More chaotropic Brand I -raise the T K with an increase of the concentration of the ions. On the other hand, less chaotropic NO 3 -initially lowers and then raises the T K . Kosmotropic F -, SO 4 2-and CO 3 2-gradually lower the T K with increasing concentration of the electrolytes. The more chaotropic ions form contact ion pairs with the surfactant and decrease the solubility with a consequent increase in the T K . On the other hand, kosmotropic ions, being extensively hydrated in the bulk, remain separated from the surfactant by hydrated layers of water molecules. As a result, a significant electrostatic repulsion exists between the charged headgroups of the surfactant, resulting in a decrease in the T K . The CMC of the surfactant decreases significantly in the presence of these ions. The surface tension at the CMC (c CMC ) also decreases in the presence of all the salts except for F -. The electrostatic repulsion between the charged headgroups is significantly reduced because of screening of the surface charge of both micelles and adsorbed monolayers by the associated counterions, resulting in a decrease in both the CMC and c CMC .

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“…The corresponding NMR spectrum in Fig. 3 (curve b) shows some shifts of T-CH 3 and c-CH 2 resonances towards higher applied field (typical ring current-induced upfiled shifts of the resonance signals assigned to protons in the surfactant units [12,15,17,21]). No significant changes are observed in the chemical shifts of the protons belonging to the rest of the main surfactant chain (i.e., N-CH 2 and x-CH 3 groups).…”

Section: Competitive Phenol Solubilization By Htab Micelles Against Hmentioning

confidence: 95%

Competitive interactions between components in surfactant–cosurfactant–additive systems

Chaghi

Ménorval

Charnay

et al. 2010

Journal of Colloid and Interface Science

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Solubilization of drugs by cationic surfactants micelles: Conductivity and 1H NMR experiments

Cited by 88 publications

References 33 publications

Synthesis and Surface Activity of Nonionic Surfactants Derived from Gallic Acid

Synthesis and Surface Activity of Nonionic Surfactants Derived from Gallic Acid

Salt‐Induced Modulation of the Krafft Temperature and Critical Micelle Concentration of Benzyldimethylhexadecylammonium Chloride

Competitive interactions between components in surfactant–cosurfactant–additive systems

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