Solubilization of fullerene in polyoxyethylene tetradecyl ether type nonionic surfactants

Kuroki, Hikaru; Aida, Erika; Komine, Takuya; Matsuoka, K.

doi:10.1016/j.molliq.2021.116236

Cited by 5 publications

(3 citation statements)

References 36 publications

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“…This Pluronic F127 sol-gel transformation with 5-FU loading is able to effectively induce the death of gastric cancer cells using a hollow microneedle injection [15]. Interactions between non-ionic micelles (not limited to Pluronic block copolymers) and small molecules (not limited to 5-FU) can be found in the literature too [16,17]. Further, binary mixing of Polymers 2021, 13, 2705 2 of 8 Pluronic F127 and Pluronic L121 produces tiny micelles that satisfy the stability criteria by demonstrating appropriate thermodynamic and kinetic stability in biologically relevant media as pharmaceutical ingredients [18].…”

Section: Introductionmentioning

confidence: 99%

Thermosensitive Interfacial Migration of 5-FU in the Microenvironment of Pluronic Block Copolymers

Lin

Yeh

2021

Polymers

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Chemotherapy is one of the most important ways to treat cancer. At present, chemotherapy medicines are mainly administered by intravenous injection or oral administration. However, systemic medical care requires the dosage of high concentrations of drugs to defeat the malignant tumor growth. In recent years, the use of polymer composites for local and sustained drug release has become an important field of research to minimize side effects due to high-concentration chemotherapy drugs. Here, 19F-{1H} heteronuclear Overhauser enhancement spectroscopy (HOESY) was used to study the micellular environment of the F-containing chemotherapeutic drug 5-FU in Pluronic F127, Pluronic L121, and F127/L121 binary blending composites. The distribution of 5-FU in micelles is related to the PEO and PPO segment length of Pluronic polymers and the environmental temperature. The drug release tests further confirm that if 5-FU medicines were loaded in the PPO segment inside the micelles, the purpose of the prolonged drug release carrier is achieved.

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Section: Introductionmentioning

confidence: 99%

Thermosensitive Interfacial Migration of 5-FU in the Microenvironment of Pluronic Block Copolymers

Lin

Yeh

2021

Polymers

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“…[10][11][12][13][14][15] They exhibit great potential for application in oil recovery, 16 lubrication, 17 photoresponsive systems, 18 and solubilization of hydrophobic gest molecules. [19][20][21] Tetradecyldimethylaminoxide (C 14 DMAO) can be viewed as a zwitterionic surfactant considering the charge separation between the N and O elements. In acidic solution, the O atom can be protonated, imparting a permanent positive charge to C 14 DMAO (Scheme 1a).…”

Section: Introductionmentioning

confidence: 99%

“…10–15 They exhibit great potential for application in oil recovery, 16 lubrication, 17 photoresponsive systems, 18 and solubilization of hydrophobic gest molecules. 19–21…”

Section: Introductionmentioning

confidence: 99%