Solubilization of hydrophobic drugs by methoxy poly(ethylene glycol)‐block‐polycaprolactone diblock copolymer micelles: Theoretical and experimental data and correlations

Linear-dendrimer type methoxy-poly (ethylene glycol)-b-poly (ɛ-caprolactone) copolymer micelles for the delivery of curcumin

“…Amphiphilic LDMP copolymer could also self-assembly form micelles with core-shell structure under water condition. The lipophilic CUR should be encapsulated into inner core by way of intermolecular hydrophobic interactions of CUR with PCL, and the drug was dissolved in water under hydration of PEG outer shell in aqueous medium (Letchford et al, 2008). Consequently, the stronger intermolecular interactions between the longer PCL block chain and lipophilic CUR might result in the higher DL and EE of CUR in LDMP.…”

“…Previous studies about CUR have indicated its ability to induce apoptosis in cancer cells (Aggarwal et al, 2003). However, CUR's inferior solubility in water was its main obstacle to remain or improve bioavailability and clinical therapeutic effect (Letchford et al, 2008).…”

Investigation on design of stable etoposide-loaded PEG-PCL micelles: effect of molecular weight of PEG-PCL diblock copolymer on thein vitroandin vivoperformance of micelles

“…Despite, significant therapeutic outcome shown by micellar drug delivery, still it remains to be fully evaluated and understood for various aspects which help to design a micellar drug delivery system which indeed act as a real carrier in vivo. Critical micelles concentration (CMC) is considered as one of the important aspect for stability of micelles and release of drug in vivo, which is usually determined by fluorescent hydrophobic probe, such as pyrene (Shi et al, 2005;Letchford et al, 2008). It is reported that lower the CMC value, higher will be the stability of micelles, which can be achieved by increasing the molecular weight of hydrophobic core part (Letchford et al, 2008).…”

“…Critical micelles concentration (CMC) is considered as one of the important aspect for stability of micelles and release of drug in vivo, which is usually determined by fluorescent hydrophobic probe, such as pyrene (Shi et al, 2005;Letchford et al, 2008). It is reported that lower the CMC value, higher will be the stability of micelles, which can be achieved by increasing the molecular weight of hydrophobic core part (Letchford et al, 2008). However, it was reported that paclitaxel dissociated quickly from MePEG-b-PDLLA micelles to blood despite lower CMC values, which implies some interaction between blood components and micelles (Burt et al, 1999).…”

Study of the Composition of Polycaprolactone/Poly (Ethylene Glycol)/Polycaprolactone Copolymer and Drug-to-Polymer Ratio on Drug Loading Efficiency of Curcumin to Nanoparticles

“…Curcumin may reduce tumor growth via multiple mechanisms, including antitumor angiogenesis, suppression of proliferation, induction of apoptosis, and prevention of metastasis (7). However, the clinical applications of curcumin remain limited because of its short biological half-life, poor solubility resulting in poor absorption, and low bioavailability via the oral route (8,9).…”