Soluble Adhesion Molecules E-Cadherin, Intercellular Adhesion Molecule-1, and E-Selectin as Lung Cancer Biomarkers

Gogali, Athena; Charalabopoulos, Konstantinos; Zampira, Iris; Konstantinidis, Athanasios; Tachmazoglou, Fanny; Daskalopoulos, George; Constantopoulos, Stavros H.; Dalavanga, Yotanna

doi:10.1378/chest.10-0157

Cited by 62 publications

(49 citation statements)

References 36 publications

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“…sE-cad levels found in preoperative serum samples are in the range reported in the literature in patients affected by this or other types of cancers (5,13,15,16,28). Values determined in patients were significantly higher than those observed in healthy subjects according to reports by other authors (5,15,16,18,28).…”

Section: Discussionsupporting

confidence: 68%

“…Values determined in patients were significantly higher than those observed in healthy subjects according to reports by other authors (5,15,16,18,28). After RRP, a significant decrease in E-cad levels was observed.…”

Section: Discussionmentioning

confidence: 40%

“…E-cad ectodomain shedding determines the release into the body fluids of a soluble 80 kDa E-cad fragment (sE-cad) (12). High sE-cad serum levels are present in cancer patients when compared with those of healthy individuals and they are significantly associated with metastasis, recurrence, and prognosis in some malignancies, including PCa (13)(14)(15)(16)(17)(18). It has been reported that sE-cad is involved in stimulation of invasion in a paracrine manner, in promotion of cell junction disruption and of cell dissemination thereby inducing the migratory phenotype (19).…”

Section: Introductionmentioning

confidence: 99%

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Soluble E-cadherin and IL-6 serum levels in patients affected by prostate cancer before and after prostatectomy

Sica¹

2012

Oncol Rep

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Abstract. Prostate specific antigen (PSA) is still the best available tumour marker in prostate cancer (PCa), but presents some limits. Therefore, there is a need for novel markers in the detection and management of PCa. The 80-kDa soluble form of E-cadherin (sE-cad) and the cytokine IL-6 are being discussed as supplemental serum markers for PCa. In this study, sE-cad and IL-6 serum levels were determined in patients with pathological localized or locally advanced PCa without any previous treatment. These patients underwent radical retropubic prostatectomy (RRP) in accordance with the EAU Guidelines on Prostate Cancer. The molecules were determined via immunoenzymatic assays in samples collected before and after surgery. Statistical analysis was performed by Student's t-test and Pearson's correlation test. sE-cad levels were 6.0±2.7 and 4.6±2.3 µg/ml, before and after RRP, respectively. A highly statistically significant decrease in sE-cad concentrations after RRP was observed (P<0.0001), in 50/61 patients (82%). sE-cad levels before and after surgery were correlated (Pearson's correlation coefficient, r=0.6993, P<0.0001). sE-cad values detected after surgery were higher in patients with PSA levels >10 ng/ml (P<0.05). sE-cad levels before RRP were significantly higher in patients with G3 tumours compared to those with G2 tumours (P<0.02). Finally, sE-cad concentrations both before and after surgery were higher in tumours with Gleason score =7 compared to those with Gleason score <7 (P<0.002 and P<0.05, respectively). Preliminary data from 20 patients indicated a statistically significant increase in IL-6 levels after RRP (11.2 vs. 7.2 pg/ml, P<0.001). This is the first study on the reduction in sE-cad levels after RRP in PCa patients. Moreover, it shows that preoperative sE-cad concentrations are higher in patients with less differentiated PCa. Promising findings of this pilot study may lead to investigation of sE-cad in a larger study with follow-up.

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Section: Discussionsupporting

confidence: 68%

Section: Discussionmentioning

confidence: 40%

Section: Introductionmentioning

confidence: 99%

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Soluble E-cadherin and IL-6 serum levels in patients affected by prostate cancer before and after prostatectomy

Sica¹

2012

Oncol Rep

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“…E-selectin is a member of the selectin family which is a family of cellular adhesion molecules contributing to cell-cell adhesion and is associated with tumor progression and metastasis. Soluble E-selectin (sE-selectin) can be used as a biomarker in the serum to detect and monitor the occurrence and development of cancer (18).…”

Section: Introductionmentioning

confidence: 99%

Expression of growth-regulated oncogene-1, hepatocyte growth factor, platelet-derived growth factor-AA and soluble E-selectin and their association with high-risk human papillomavirus infection in squamous cell carcinoma of the uterine cervix

Zhang

Yang

et al. 2014

Molecular Medicine Reports

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Abstract. The aim of the present study was to evaluate the clinical significance and prognostic value of growth-regulated oncogene-1 (GRO-1), hepatocyte growth factor (HGF), platelet-derived growth factor-AA (PDGF-AA), soluble E-selectin (sE-selectin) and high-risk human papillomavirus (HPV; types 16, 18/45, 31 and 33/52/58/67) infection in cervical squamous cell carcinoma (CSCC). A total of 426 cases were enrolled in the present study, of which 292 cases were patients with CSCC, 43 were patients with cervical intraepithelial neoplasia (CIN) and 91 were healthy controls. Luminex xMAP technology was used to detect the serum levels of GRO-1, HGF, PDGF-AA and sE-selectin in all cases and two-channel fluorescence quantitative polymerase chain reaction was used to determine HPV DNA in cervical scrapings from CSCC and CIN patients. The results demonstrated that the serum levels of GRO-1, HGF and sE-selectin were significantly higher in patients with CSCC compared with patients with CIN and the healthy controls (P<0.0001). Compared with the CIN patients, the HPV positive rate in the CSCC patients significantly increased (P= 0.013). The four factors were correlated with certain clinicopathological variables of CSCC patients to a certain degree (P<0.05) and the levels of HGF were closely associated with HPV infection (P= 0.039). The receiver operating characteristic curves demonstrated that HGF obtained the highest diagnostic value compared with the other three factors. Multivariate Cox regression analysis demonstrated that the serum levels of HGF (P<0.0001), FIGO stage (P<0.0001) and pelvic lymph node metastasis (P=0.001) were independent prognostic factors in patients with CSCC, while high-risk HPV infection did not show any significance in this analysis. These results demonstrated that HGF may be a useful prognostic biomarker rather than high-risk HPV types in patients with CSCC.

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“…Whilst soluble form of ICAM-1 (sICAM-1) is partly detectable in the serum of healthy subjects, its level increases in malignancies. sICAM-1 serum level is associated with tumor size, lymph node and distant metastasis of cancers, including breast cancer, pancreatic cancer, gastric cancer, lung cancer and hepatocellular carcinoma (Nakata et al, 2000;Felding-Habermann et al, 2001;Alexiou et al, 2003;Moriyama et al, 2006;Gogali et al, 2010;Brand et al, 2011;Eggeman et al, 2011). Gliomas call for disruption of endothelial cell-cell attachment and cell-matrix adhesion, cell migration, and formation of new cell-cell interactions.…”

Section: Introductionmentioning

confidence: 99%

Investigation of ICAM-1 and β3 Integrin Gene Variations in Patients with Brain Tumors

Yılmaz

Zeybek²,

Kahraman³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Background: Primary brain tumors constitute a small percent of all malignant cancers, but their etiology remains poorly understood. β3 integrin (ITGB3) has been recognized to play influential roles in angiogenesis, tumor growth and metastasis. Intercellular adhesion molecule-1 (ICAM-1) is a surface glycoprotein important for tumor invasion and angiogenesis. The aim of this study was to investigate whether specific genetic polymorphisms of ICAM-1 and ITGB3 could be associated with brain cancer development and progression in a Turkish population. Our study is the first to our knowledge to investigate the relationship between brain tumor risk and ICAM-1 and β3 integrin gene polymorphisms. Materials and Methods: The study covered 92 patients with primary brain tumors and 92 age-matched healthy control subjects. Evaluation of β3 integrin (Leu33Pro (rs5918)) and ICAM-1 (R241G (rs1799969) and K469E (rs5498)) gene polymorphisms was performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: According to results of our research, the A allele of the ICAM-1 R241G gene polymorphism appeared to be a risk factor for primary brain tumors (p<0.001). Similarly, the frequency of the A mutant allele of ICAM-1 R241G was statistically significant in patients with brain tumors classified as glioma (p<0.001). When allele and genotype distributions of ICAM-1 K469E, ICAM-1 R241G and β3 integrin Leu33Pro gene polymorphisms were evaluated with age, sex, and smoking, there were no statistically significant differences. Haplotype analysis revealed that the frequencies of GAC (rs1799969-rs5498-rs5918) and GAT (rs1799969-rs5498-rs5918) haplotypes were significantly lower in patients as compared with controls (p=0.001; p=0.036 respectively). Conclusions: This study provides the first evidence that ICAM-1 R241G SNP significantly contributes to the risk of primary brain tumors in a Turkish population. In addition, our results suggest that ICAM-1 R241G in combination ICAM-1 K469E may have protective effects against the development of brain cancer.

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Soluble Adhesion Molecules E-Cadherin, Intercellular Adhesion Molecule-1, and E-Selectin as Lung Cancer Biomarkers

Cited by 62 publications

References 36 publications

Soluble E-cadherin and IL-6 serum levels in patients affected by prostate cancer before and after prostatectomy

Soluble E-cadherin and IL-6 serum levels in patients affected by prostate cancer before and after prostatectomy

Expression of growth-regulated oncogene-1, hepatocyte growth factor, platelet-derived growth factor-AA and soluble E-selectin and their association with high-risk human papillomavirus infection in squamous cell carcinoma of the uterine cervix

Investigation of ICAM-1 and β3 Integrin Gene Variations in Patients with Brain Tumors

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