Soluble adhesion molecules (ICAM-1, VCAM-1, and E-selectin) and vascular endothelial growth factor (VEGF) in patients with distinct variants of rheumatoid synovitis

Klimiuk, Piotr Adrian

doi:10.1136/ard.61.9.804

Cited by 118 publications

(88 citation statements)

References 38 publications

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“…Functional HA-CD44 interaction that causes NF-κ B down-regulation in activated macrophages is supported by additional data that anti-CD44 antibody cancels the inhibitory effect of HA on AGE-induced translocation of NF-κ B complex into the nucleus in J774 mouse macrophages (Neumann et al 1999). In RA synovial tissues, CD44 (Aruffo et al 1990) and ICAM-1 (Klimiuk et al 2002) are over-expressed in proportion to the severity of synovial inflammation, suggesting the critical roles of HA receptors in the pathology of RA. Therefore, the occupation of HA receptors by exogenous HA of intrinsic normal molecular weight may protect cells from transduction of catabolic signals through the mechanism demonstrated in the present study.…”

Section: Discussionmentioning

confidence: 48%

Hyaluronan Inhibits Prostaglandin E2 Production via CD44 in U937 Human Macrophages

Yasuda

2010

Tohoku J. Exp. Med.

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Section: Discussionmentioning

confidence: 48%

Hyaluronan Inhibits Prostaglandin E2 Production via CD44 in U937 Human Macrophages

Yasuda

2010

Tohoku J. Exp. Med.

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“…Elevated amounts of a biologically active form of sI-CAM is detected in serum, cerebrospinal fluid, synovial fluid, urine and sputum in pathologies with an underlying inflammatory status, like autoimmune and degenerative diseases [213][214][215] and tumor pathogenesis [216,217] . Different reports point to various cell sources of sICAM in health and pathologies, including endothelial cells [218] , peripheral blood mononuclear cells, keratinocytes, epidermoid carcinoma cell lines, melanoma cells [219] and tumors [216,217,220] .…”

Section: Intercellular Adhesion Moleculementioning

confidence: 99%

Secretion of immunoregulatory cytokines by mesenchymal stem cells

Kyurkchiev

Bochev

Ivanova‐Todorova

et al. 2014

WJSC

526

392

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According to the minimal criteria of the International Society of Cellular Therapy, mesenchymal stem cells (MSCs) are a population of undifferentiated cells defined by their ability to adhere to plastic surfaces when cultured under standard conditions, express a certain panel of phenotypic markers and can differentiate into osteogenic, chondrogenic and adipogenic lineages when cultured in specific inducing media. In parallel with their major role as undifferentiated cell reserves, MSCs have immunomodulatory functions which are exerted by direct cell-to-cell contacts, secretion of cytokines and/or by a combination of both mechanisms. There are no convincing data about a principal difference in the profile of cytokines secreted by MSCs isolated from different tissue sources, although some papers report some quantitative but not qualitative differences in cytokine secretion. The present review focuses on the basic cytokines secreted by MSCs as described in the literature by which the MSCs exert immunodulatory effects. It should be pointed out that MSCs themselves are objects of cytokine regulation. Hypothetical mechanisms by which the MSCs exert their immunoregulatory effects are also discussed in this review. These mechanisms may either influence the target immune cells directly or indirectly by affecting the activities of predominantly dendritic cells. Chemokines are also discussed as participants in this process by recruiting cells of the immune systems and thus making them targets of immunosuppression. This review aims to present and discuss the published data and the personal experience of the authors regarding cytokines secreted by MSCs and their effects on the cells of the immune system. © 2014 Baishideng Publishing Group Inc. All rights reserved.Key words: Mesenchymal stem cells; Immunomodulation; Cytokines; Chemokines; Dendritic cells Core tip: Autoimmune diseases affect approximately 5% of the human population, leading to serious disability and effective methods to treat these diseases are still not perfect. Mesenchymal stem cells (MSCs) are assumed to be promising agents, both for regenerative medicine and cell therapy for autoimmune disorders. Under the influence of some factors, mesenchymal stem cells secrete cytokines which induce suppression of the immune response. Studies on the secreted cytokines and the precise mechanisms involved in these suppressive mechanisms would create possibilities for efficient application of MSCs as a therapeutic means for treatment of autoimmune diseases.Kyurkchiev D, Bochev I, Ivanova-Todorova E, Mourdjeva M, REVIEWSubmit a

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“…129 More recently, another study showed that the incorporation of SAA together with anti-CCP in a RA diagnosis model, increased the sensitivity compared with the anti-CCP alone, but decreased the selectivity of the model. 86 Others markers of inflammation such as ESelectin, 130,131 Thioredoxin, 132,133 intracellular adhesion molecule (I-CAM)1 130,[134][135][136] and vascular cell adhesion molecule (V-CAM)1 130,135,137 have been found to correlate with disease activity in RA but there is little evidence to suggest that additional information is gained over and above measurement of ESR and CRP. Thus, ESR and CRP remain the two biomarkers used routinely in clinical practice.…”

Section: Serum Amyloid-associated Proteinmentioning

confidence: 99%