Soluble adhesion molecules in Gilles de la Tourette's syndrome

Martino, Davide; Church, Andrew J.; Defazio, Giovanni; Dale, Russell C.; Quinn, Niall; Robertson, Mary M.; Livrea, Paolo; Orth, M.; Giovannoni, Gavin

doi:10.1016/j.jns.2005.03.032

Cited by 29 publications

(20 citation statements)

References 44 publications

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“…In a British cohort of 100 patients with GTS (50% children), ASOT was raised in 64% of children and in 68% of adults with GTS; this was significantly higher than in neurological disease and healthy control subjects [13]. Two other reports from British and Italian cohorts confirmed these findings [14,15]. However, a subsequent study failed to find a significant association with ASOT and anti-DNAse B titers using the same cross-sectional approach [16].…”

Section: The Original Description Of Pandasmentioning

confidence: 89%

“…Recent work has documented that children with GTS and/ or OCD show changes in cell-mediated immunity, characterized by increased levels of proinflammatory cytokines [14,62] and higher expression of genes related to the control of function of natural killer and cytotoxic T cells [63]. Moreover, a predisposition to autoimmune responses is suggested by a reduced percentage of T regulatory lymphocytes [64].…”

Section: What Is the Full Range Of Symptoms In Patients With Pandas?mentioning

confidence: 99%

See 1 more Smart Citation

The PANDAS subgroup of tic disorders and childhood-onset obsessive–compulsive disorder

Martino¹,

Defazio²,

Giovannoni³

2009

Journal of Psychosomatic Research

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Section: The Original Description Of Pandasmentioning

confidence: 89%

Section: What Is the Full Range Of Symptoms In Patients With Pandas?mentioning

confidence: 99%

The PANDAS subgroup of tic disorders and childhood-onset obsessive–compulsive disorder

Martino¹,

Defazio²,

Giovannoni³

2009

Journal of Psychosomatic Research

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“…The inflammation theory of TS suggests that an initial immune response exposes neurons to an elevated level of cytokines (Leckman et al, 2005), which may lead to endothelial cell damage or proteolytic degradation (Martino et al, 2005). Possible autoimmunity involving antistreptococcal autoantibodies that cross-react with neuronal cells of TS patients has been suggested (Martino et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Hyperpolarisation-activated cyclic nucleotide channel 4 (HCN4) involvement in Tourette's syndrome autoimmunity

Yeh

Shui

Chu

et al. 2012

Journal of Neuroimmunology

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“…Além disso, em alguns pacientes, observou-se declínio no número de células T regulató-rias durante a exacerbação dos sintomas. Pacientes com ST também podem apresentar elevação de alguns tipos de moléculas de adesão 84 . O aumento das moléculas de adesão em pacientes com ST é uma evidência do envolvimento de processos imunes, pois é um fenômeno observado durante a inflamação.…”

Section: Investigando a Validade Da Hipótese Auto-imune Na Síndrome Dunclassified

Neurobiologia da síndrome de Tourette: a hipótese auto-imune pós-estreptocócica

Dias¹,

Kümmer²,

Hounie³

et al. 2008

Rev. psiquiatr. clín.

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ResumoContexto: A síndrome de Tourette (ST) caracteriza-se pela presença de tiques motores e pelo menos um tique fônico. Algumas semelhanças clínicas com a coréia reumática ou de Sydenham (CS) incentivaram a formulação da hipótese da existência de um grupo de transtornos neuropsiquiátricos associados a processo auto-imune decorrente de infecção estreptocócica (PANDAS). Objetivo: Revisar a literatura quanto às evidências em relação à hipótese de que mecanismos auto-imunes pós-estreptocócicos estão envolvidos na etiopatogênese da ST. Métodos: Revisão sistemática na base de dados MedLine com os termos "Tourette", "tic", "PANDAS", "antibodies", "streptococcal" e "rheumatic". Resultados: Retornaram 238 artigos da busca. Selecionaram-se 53 trabalhos, os quais tiveram suas referências bibliográficas também revisadas. São apresentados os resultados de estudos que avaliaram aspectos imunes na ST, incluindo anticorpos antiestreptocócicos e antinúcleos da base, e sua terapêutica imunebaseada, discutindo a validade do conceito de PANDAS. Conclusões: As evidências ainda não são satisfatórias no que tange a uma base auto-imune pós-estreptocócica para a ST. Um aprimoramento dos métodos investigativos e na seleção das amostras pode trazer maiores contribuições à questão. FMV, et al. / Rev Psiq Clín. 2008;35(6):228-35 Palavras-chave: Síndrome de Tourette, coréia de Sydenham, infecção estreptocócica, auto-imune, PANDAS, febre reumática, tiques. Dias AbstractBackground: Tourette's syndrome (TS) is characterized by the presence of motor tics and at least one phonic tic. Some clinical similarities with Sydenham's chorea (SC) lead to the hypothesis of a new group of disorders associated with an autoimmune process due to a streptococcal infection (PANDAS). Objective: To review the literature in search of evidence on the existence of post-streptococcal autoimmune mechanisms involved with the etiopathogenesis of TS. Methods: A systematic review with the terms "Tourette", "tic", "PANDAS", "antibodies", "streptococcal" and "rheumatic" was carried on using the MedLine. Results: The search found 238 articles. Fifty and three articles were selected which also had their references reviewed. The results of studies that investigated autoimmune aspects of TS, including anti-streptococcal and anti-basal ganglia anti-bodies, and immune-based therapy, were presented and discussed. Discussion: The evidences to date are not satisfactory regarding a post-streptococcal auto-immune process in ST. The improvement on investigative methods and sample selection might contribute to this question.

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Soluble adhesion molecules in Gilles de la Tourette's syndrome

Cited by 29 publications

References 44 publications

The PANDAS subgroup of tic disorders and childhood-onset obsessive–compulsive disorder

The PANDAS subgroup of tic disorders and childhood-onset obsessive–compulsive disorder

Hyperpolarisation-activated cyclic nucleotide channel 4 (HCN4) involvement in Tourette's syndrome autoimmunity

Neurobiologia da síndrome de Tourette: a hipótese auto-imune pós-estreptocócica

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