Soluble and membranous endothelial protein C receptor in systemic lupus erythematosus patients: Relation to nephritis

Shaaban, Asmaa; El-Kadery, Nadia Abd-El Salam; Elshamy, Hebat-Allah A.; Elhefnawy, Nadia G.; Mohamed, Nesrine A

doi:10.1016/j.ejr.2018.03.002

Cited by 3 publications

(2 citation statements)

References 37 publications

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“…This goes in accordance with Mendez and colleagues (2013) who did not find any association between mEPCR expression and ISN/RPS classification when they examined the renal biopsies of 34 adult patients with LN 25 . Same was found by Shabaan et al, 2018 26 .…”

Section: Discussionsupporting

confidence: 78%

Membrane endothelial protein C receptor expression in renal tissue of pediatric lupus nephritis patients

Ibrahim

El-Sayed

Said

et al. 2019

Egypt J Pediatr Allergy Immunol

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Background: Lupus nephritis (LN) is more common and more severe is pediatric systemic lupus erythematosus (pSLE). Endothelial protein C receptor (EPCR) is an inducer of anti-apoptotic pathways in endothelial cells. Recent studies have taken elevated anti-injury biomarkers as EPCR into consideration regarding their roles to antagonize LN. Objectives: to evaluate the membrane expression of endothelial protein C receptor (mEPCR) in the renal microvasculature in pediatric patients with LN. Methods This study was conducted on 25 patients with pSLE following up at

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Section: Discussionsupporting

confidence: 78%

Membrane endothelial protein C receptor expression in renal tissue of pediatric lupus nephritis patients

Ibrahim

El-Sayed

Said

et al. 2019

Egypt J Pediatr Allergy Immunol

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“…Moreover, complications of SLE, such as lupus nephritis (LN), can also affect the levels of EPCR. While SLE causes elevated sEPCR levels, patients with LN have significantly higher levels of sEPCR than patients with SLE who do not develop LN [155][156][157]. The increase in sEPCR levels in LN patients may be explained by the conversion of elevated mEPCR levels, which are found in the cortical peritubular capillaries of these patients, to sEPCR due to the shedding by the inflammatory cytokines IFN-γ and IL-1 [46,155].…”

Section: Epcr and Slementioning

confidence: 99%

Endothelial Protein C Receptor and Its Impact on Rheumatic Disease

O’Hehir,

Lynch,

O’Neill

et al. 2024

JCM

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Endothelial Protein C Receptor (EPCR) is a key regulator of the activated protein C anti-coagulation pathway due to its role in the binding and activation of this protein. EPCR also binds to other ligands such as Factor VII and X, γδ T-cells, plasmodium falciparum erythrocyte membrane protein 1, and Secretory group V Phospholipases A2, facilitating ligand-specific functions. The functions of EPCR can also be regulated by soluble (s)EPCR that competes for the binding sites of membrane-bound (m)EPCR. sEPCR is created when mEPCR is shed from the cell surface. The propensity of shedding alters depending on the genetic haplotype of the EPCR gene that an individual may possess. EPCR plays an active role in normal homeostasis, anti-coagulation pathways, inflammation, and cell stemness. Due to these properties, EPCR is considered a potential effector/mediator of inflammatory diseases. Rheumatic diseases such as rheumatoid arthritis and systemic lupus erythematosus are autoimmune/inflammatory conditions that are associated with elevated EPCR levels and disease activity, potentially driven by EPCR. This review highlights the functions of EPCR and its contribution to rheumatic diseases.

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Role of syndecan-1 (CD138) in Egyptian systemic lupus erythematosus patients with lupus nephritis: Relation to disease activity

Salam

Khalil

Alnaggar

et al. 2019

The Egyptian Rheumatologist

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Soluble and membranous endothelial protein C receptor in systemic lupus erythematosus patients: Relation to nephritis

Cited by 3 publications

References 37 publications

Membrane endothelial protein C receptor expression in renal tissue of pediatric lupus nephritis patients

Membrane endothelial protein C receptor expression in renal tissue of pediatric lupus nephritis patients

Endothelial Protein C Receptor and Its Impact on Rheumatic Disease

Role of syndecan-1 (CD138) in Egyptian systemic lupus erythematosus patients with lupus nephritis: Relation to disease activity

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