Soluble Antimicrobial Peptide Pyocin of Pseudomonas aeruginosa and its Therapeutics: A Review Article

Abstract

Pyocinsis a bacteriocin produced by a group of Gram-ngative bacteria that belongs to Pseudomonasspecies. Pyocin is classified as a two distinct families of pyocins. (i) S-type pyocins (colicin-like bacteriocins), (ii) Tailocins (high-molecular weight bacteriocins that resemble phage tails).The structure of S-type pyocin is similar to that of colicin except that many S-type pyocins have three domains. Under normal conditions, the expression of prtN is repressed by PrtR. Upon exposure to stress conditions, such as DNA damage by chemicals or ultraviolet irradiation, an activated RecA triggers autoproteolytic cleavage of PrtR, which abrogates prtN repression and leads to pyocinproduction. The outer membrane receptors for three pyocins have been identified. These are FpvAI, FpvAII and FptA, all of which are involved in the uptake of iron-siderophore complexes. Before being translocated through the membrane and killing their target.This is becoming increasingly important as microbial imbalances in the natural gut flora have been suggested to play a role in a range of chronic diseases such as inflammatory bowel disease, diabetes, obesity and rheumatoid arthritis.Pyocin has now been shown to have antimicrobial activity againstbacteria in a biofilm is a limiting factor in the successful treatment of a range of chronic infections.