Soluble CD163 Is Associated With CD163 mRNA Expression in Adipose Tissue and With Insulin Sensitivity in Steady-State Condition but Not in Response to Calorie Restriction

Kračmerová, Jana; Rossmeislová, Lenka; Kováčová, Zuzana; Klimčáková, Eva; Polàk, Jan; Tencerová, Michaela; Mališová, Lucia; Štich, Vladimír; Langin, Dominique; Šiklová, Michaela

doi:10.1210/jc.2013-3348

Cited by 28 publications

(31 citation statements)

References 25 publications

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“…To the extent sCD163 concentrations reflect WAT inflammation, this is in accordance with varying obesity-associated WAT inflammation between individuals, possibly due to depot-specific differences. WAT macrophages highly express CD163 mRNA (19), and CD163 mRNA expression in SAT and VAT is positively associated with sCD163 (26). Consistent with this, studies in non-diabetic subjects have demonstrated that measures of adiposity including BMI, waist circumference, SAT, and VAT are positively associated with sCD163 (20, 21, 22).…”

Section: Introductionmentioning

confidence: 56%

“…In a retrospective cohort study, it has been demonstrated that baseline increased sCD163 concentration is a strong risk marker for developing T2DM in the general population independently of BMI and age (25). Furthermore, in recent cross-sectional studies, we and others have demonstrated that sCD163 is strongly associated with insulin resistance as assessed by HOMA-IR (20, 21, 24) and euglycemic hyperinsulinemic clamp technique (26), which was evident in normal-weight and obese healthy individuals (20, 21, 26), as well as in individuals with normal glucose tolerance (NGT), impaired glucose tolerance (IGT), and T2DM (24). Interestingly, in our study including subjects with NGT, IGT, and T2DM, sCD163 as well as TNFα, IL6, and CRP concentrations increased with deteriorating glycemic control even though the groups were BMI matched (BMI ∼30 kg/m 2 ) (24).…”

Section: Introductionmentioning

confidence: 71%

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Visceral obesity is associated with increased soluble CD163 concentration in men with type 2 diabetes mellitus

Sørensen¹,

Parkner²,

Søndergaard³

et al. 2015

Endocrine Connections

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Monocyte/macrophage-specific soluble CD163 (sCD163) concentration is associated with insulin resistance and increases with deteriorating glycemic control independently of BMI. This led to the proposal of the hypothesis that obesity-associated white adipose tissue inflammation varies between individuals. The objective was to examine the effect of male overweight/obesity and type 2 diabetes mellitus (T2DM) on associations between adiposity parameters and sCD163. A total of 23 overweight/obese non-diabetic men, 16 overweight/obese men with T2DM, and a control group of 20 normal-weight healthy men were included. Body composition and regional body fat distribution were determined by whole-body dual X-ray absorptiometry scan and abdominal computed tomography (CT) scan. Serum sCD163 concentrations were determined by ELISA. Associations between adiposity parameters and sCD163 were investigated using multiple linear regression analysis. In the normal-weight healthy men, there was no significant association between adiposity parameters and sCD163, whereas in the overweight/obese non-diabetic men, measures of general and regional adiposity were positively associated with sCD163. In the overweight/obese men with T2DM, only visceral adipose tissue (VAT) and the ratio of VAT to abdominal subcutaneous adipose tissue (SAT), a measure of relative body fat distribution between VAT and SAT depots, were positively associated with sCD163. In a multivariate analysis, including VAT, upper-body SAT, and lower-body fat, adjusted for BMI and age, VAT remained a significant predictor of sCD163 in the overweight/obese T2DM men, but not in the overweight/obese non-diabetic men. Our results indicate that VAT inflammation is exaggerated in men with T2DM, and that propensity to store excess body fat viscerally is particularly detrimental in men with T2DM.

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Section: Introductionmentioning

confidence: 56%

Section: Introductionmentioning

confidence: 71%

Visceral obesity is associated with increased soluble CD163 concentration in men with type 2 diabetes mellitus

Sørensen¹,

Parkner²,

Søndergaard³

et al. 2015

Endocrine Connections

View full text Add to dashboard Cite

show abstract

“…Although a definitive direct connection between the increased sCD163 levels observed in OSA patients and the adipose tissue as a source cannot be drawn at this stage, the results from the animal model nonetheless suggest that this may be the case. In support of this hypothesis, a recent study demonstrated a significant correlation of sCD163 with CD163 expression in adipose tissue [29]. CD163 is expressed on M2 macrophages but to become soluble requires cleavage by ADAM-17, which is dependent on M1 macrophages [30].…”

Section: Discussionmentioning

confidence: 82%

Intermittent hypoxia in obstructive sleep apnoea mediates insulin resistance through adipose tissue inflammation

et al. 2017

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Obstructive sleep apnoea (OSA) is increasingly associated with insulin resistance. The underlying pathophysiology remains unclear but intermittent hypoxia (IH)-mediated inflammation and subsequent dysfunction of the adipose tissue has been hypothesised to play a key role.We tested this hypothesis employing a comprehensive translational approach using a murine IH model of lean and diet-induced obese mice, an innovative IH system for cell cultures and a tightly controlled patient cohort.IH led to the development of insulin resistance in mice, corrected for the degree of obesity, and reduced insulin-mediated glucose uptake in 3T3-L1 adipocytes, associated with inhibition of the insulin-signalling pathway and downregulation of insulin-receptor substrate-1 mRNA. Providing mechanistic insight, IH induced a pro-inflammatory phenotype of visceral adipose tissue in mice with pro-inflammatory M1 macrophage polarisation correlating with the severity of insulin resistance. Complimentary analysis demonstrated that IH led to M1 polarisation of THP1-derived macrophages. In subjects without comorbidities (n=186), OSA was independently associated with insulin resistance. Furthermore, we found an independent correlation of OSA severity with the M1 macrophage inflammatory marker sCD163.This study provides evidence that IH induces a pro-inflammatory phenotype of the adipose tissue, which may be a crucial link between OSA and the development of insulin resistance.

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“…Serum sCD163 levels are significantly higher in obese patients compared with in lean patients, whereas efferocytosis by M2 macrophages appears to be impaired in obese patients (61–63). A low-fat diet reduced the levels of sCD163 (64,65); however, a 12-week exercise program had no such effect (66). …”

Section: Clinical Significance Of Scd163 Expressionmentioning

confidence: 98%

Clinical significance of sCD163 and its possible role in asthma

Zhi

Gao

Xin

et al. 2017

Molecular Medicine Reports

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Macrophages exert important functions in the balance and efficiency of immune responses, and participate in innate and adaptive immunity. The proinflammatory actions of macrophages are implicated in autoimmune diseases. Unlike classically activated M1 macrophages, the alternatively activated cluster of differentiation (CD)163+ and CD206+ M2 macrophages are involved in tissue repair and wound healing, and use oxidative metabolism to support their long-term functions. CD163 is a member of the scavenger receptor superfamily, categorized into class B, and its soluble(s) form, sCD163, is a marker of activated M2 macrophages. CD163 is selectively expressed in cells of the monocyte and macrophage lineages; however, its biological role has yet to be elucidated. The expression of sCD163 is markedly induced by anti-inflammatory mediators, such as glucocorticoids and interleukin-10, whereas it is inhibited by proinflammatory mediators, such as interferon-γ. These findings suggest that CD163 may serve as a potential target for the therapeutic modulation of inflammatory responses. The concentration of sCD163 in blood is associated with acute and chronic inflammatory processes in autoimmune disorders of connective tissue, fat metabolism and cardiovascular diseases, and it can be used for the assessment of cancer prognosis. A role for sCD163 in the pathogenesis of asthma has also been proposed. The present review serves to present the available knowledge concerning the implication of sCD163 in the pathophysiological mechanisms of asthma, and evaluate its potential as a biomarker and possible therapeutic target for asthma.

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Soluble CD163 Is Associated With CD163 mRNA Expression in Adipose Tissue and With Insulin Sensitivity in Steady-State Condition but Not in Response to Calorie Restriction

Abstract: sCD163 correlates with CD163 mRNA expression in sc and visc AT and with whole-body insulin sensitivity in the steady-state condition. These associations are not observed with respect to the diet-induced changes during a weight-reducing hypocaloric diet.

Cited by 28 publications

References 25 publications

Visceral obesity is associated with increased soluble CD163 concentration in men with type 2 diabetes mellitus

Visceral obesity is associated with increased soluble CD163 concentration in men with type 2 diabetes mellitus

Intermittent hypoxia in obstructive sleep apnoea mediates insulin resistance through adipose tissue inflammation

Clinical significance of sCD163 and its possible role in asthma

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