Soluble Endoglin (CD105) Serum Level as a Potential Marker in the Management of Head and Neck Paragangliomas

Litwiniuk, Małgorzata; Niemczyk, Kazimierz; Niderla-Bielińska, Justyna; Łukawska-Popieluch, Izabela; Grzela, Tomasz

doi:10.1177/0003489417727548

Cited by 7 publications

(4 citation statements)

References 15 publications

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“…These findings are in agreement with several in vivo and in vitro studies supporting an active role of sEng in endothelial dysfunction and vascular remodeling [33][34][35]. Increased circulating levels of sEng have also been proposed as a prognosis marker in cancer [36], including breast cancer [37], prostate cancer [38], colorectal cancer [39], or head and neck paragangliomas [40], and a marker of cancer metastasis [36,37,41]. In addition, patients receiving metastasis-positive chemotherapy with solid tumors showed markedly decreased sEng levels compared with those of a comparable untreated group of patients (median: 64.8 ng/mL vs 36.1 ng/mL, respectively), suggesting that sEng may be used for monitoring cancer relapse in a long-term follow-up [41].…”

Section: Introductionsupporting

confidence: 90%

Soluble endoglin reduces thrombus formation and platelet aggregation via interaction with αIIbβ3 integrin

Rossi¹,

Pericacho²,

Kauskot³

et al. 2023

Journal of Thrombosis and Haemostasis

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Section: Introductionsupporting

confidence: 90%

Soluble endoglin reduces thrombus formation and platelet aggregation via interaction with αIIbβ3 integrin

Rossi¹,

Pericacho²,

Kauskot³

et al. 2023

Journal of Thrombosis and Haemostasis

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“…CD105 is expressed not only in vascular endothelial cells, but it is also detected in several malignancies including gastrointestinal stromal tumours, hepatocellular carcinoma, and breast cancer (34–36), head and neck paragangliomas (37), and OC ascites (38). Furthermore, CD105-expressing cells have multi-differentiation potential: CD105-positive rhabdoid meningioma cells exhibit SC-like features and have the capacity to differentiate into adipocytes and osteocytes (39).…”

Section: Discussionmentioning

confidence: 99%

Human epithelial ovarian cancer cells expressing CD105, CD44 and CD106 surface markers exhibit increased invasive capacity and drug resistance

et al. 2019

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The high rate of mortality associated with ovarian cancer (OC) is due in part to the development of resistance to chemotherapy, which allows the resistant tumour cells to invade and metastasise. Clarifying the mechanistic basis for drug resistance may reveal novel avenues for treatment. The present study investigated the mechanism of paclitaxel (PTX) resistance in human epithelial OC by evaluating the expression of stem cell-associated cell surface markers endoglin (CD105), CD44 antigen and vascular cell adhesion molecule 1 (CD106), in association with the malignant potential of the human OC OVCAR3 cell line and its PTX-resistant derivative OC3/TAX300. The expression of CD105, CD44 and CD106 was detected by reverse transcription quantitative polymerase chain reaction (RT-qPCR) and flow cytometry, and cell invasion was evaluated using a Transwell invasion assay. CD105, CD44 and CD106 levels were increased in OC3/TAX300 cells compared with the OVCAR3 cells, as determined by flow cytometry (P<0.01) and RT-qPCR (P<0.05). Additionally, the number of invading cells was increased in the OC3/TAX300 group compared with the OVCAR3 group (54.7±6.65 vs. 31.8±6.55; P<0.01). A western blot analysis of cell surface marker expression in 80 clinical epithelial OC tissue samples, differing in terms of sensitivity to drug treatments, disease stage and degree of differentiation, revealed that high CD105, CD44 or CD106 expression was associated with drug resistance, advanced disease stage, poor differentiation and high rate of recurrence. These data indicated that exposure to high doses of PTX enhanced the stem-like properties of OC cells, which are associated with drug resistance and invasion and lead to poor prognosis due to induced chemoresistance and/or metastasis. Therefore, CD105, CD44 and CD106 may serve as potential stem cell-associated cell surface and prognostic markers, and therapeutic targets, in OC.

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“…sEng is released through the proteolytic cleavage of the extracellular domain of membrane Endoglin by the metalloprotease MMP14 [23]. An increase in sEng in circulation occurs during different pathophysiological processes, such as endothelial injury, migration, angiogenesis, inflammation, cardiovascular diseases, preeclampsia, and tumor angiogenesis [24][25][26][27].…”

Section: Introductionmentioning

confidence: 99%

Endoglin (CD105) and VEGF as potential angiogenic and dissemination markers for colorectal cancer

et al. 2020

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Background: Colorectal cancer (CRC) is an important current problem concerning public health due to its high incidence and mortality. Advances in molecular and cellular knowledge and the detection of new disease biomarkers are very important to improve prognosis, prediction, and early diagnosis. In this study, we aimed to analyze the gene and protein expression levels of two angiogenic markers, VEGF and soluble Endoglin, during different tumor stages as well as at different stages of cancer treatment, to predict the diagnosis and evolution of colon and rectal cancer. Material and methods: This study includes 133 CRC patients (93 with colon cancer and 40 with rectal cancer) on which the gene and protein expression of Endoglin (membrane and soluble form) and VEGF were analyzed by molecular and immunohistochemical techniques on different tumor stage samples and plasma obtained preoperatively as well as 3, 6, and 9 months after resection of the tumor. Results: VEGF and Endoglin gene expressions were higher in tumor tissue than in surrounding non-tumoral tissue for both types of cancer. The VEGF levels in plasma were found to decrease in less aggressive tumors, whereas soluble Endoglin was increased in preoperative samples of patients with metastasis. Membrane Endoglin expression was higher on the vascular endothelium of more aggressive tumors. In contrast, Endoglin expression was mainly in the colon epithelium in less aggressive stage tumors. Conclusion: Endoglin and VEGF are proteins with a major role in the tumor angiogenesis process. This study performed with a wide cohort of human samples shows that both proteins seem to be valuable biomarkers in the diagnosis and prognosis of CRC.

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Soluble Endoglin (CD105) Serum Level as a Potential Marker in the Management of Head and Neck Paragangliomas

Abstract: Endoglin is an important factor in the pathophysiology of head and neck paragangliomas and may be a potential diagnostic and prognostic marker in these types of tumors.

Cited by 7 publications

References 15 publications

Soluble endoglin reduces thrombus formation and platelet aggregation via interaction with αIIbβ3 integrin

Soluble endoglin reduces thrombus formation and platelet aggregation via interaction with αIIbβ3 integrin

Human epithelial ovarian cancer cells expressing CD105, CD44 and CD106 surface markers exhibit increased invasive capacity and drug resistance

Endoglin (CD105) and VEGF as potential angiogenic and dissemination markers for colorectal cancer

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