Soluble epoxide hydrolase inhibitory activity by rhizomes of Kaempferia parviflora Wall. ex Baker

Discovery of Soluble Epoxide Hydrolase Inhibitors from Chemical Synthesis and Natural Products

“…145 In addition, 3,5,7-trimethoxyflavone (94), 5,7,4′-trimethoxyflavone (95), 3,5,7,4′-tetramethoxyflavone (96), 3,5,7,3′,4′-pentamethoxyflavone (97), and 4′,5-dihydroxy-3,3′,7-trimethoxyflavone (98), isolated from K. parvi-f lora, displayed potent inhibitory potentials with K i values ranging from 0.1 μM to 1.7 μM. 155 2.3.3. Triterpenoids.…”

“…Some of flavonoids, isolated and identified from the genera Scutellaria , Tetrastigma , Epimedium , Apios , Kaempferia , Boscia , and so on, exhibited sEH inhibitory potencies (Figure ). ,,− …”

“…The investigation on T. hemsleyanum led to the isolation of kaempferol ( 92 ) and apigenine ( 93 ), and they were defined as noncompetitive-type inhibitors with K i values of 18.6 and 24.4 μM, respectively . In addition, 3,5,7-trimethoxyflavone ( 94 ), 5,7,4′-trimethoxyflavone ( 95 ), 3,5,7,4′-tetramethoxyflavone ( 96 ), 3,5,7,3′,4′-pentamethoxyflavone ( 97 ), and 4′,5-dihydroxy-3,3′,7-trimethoxyflavone ( 98 ), isolated from K. parviflora , displayed potent inhibitory potentials with K i values ranging from 0.1 μM to 1.7 μM …”

7-O-Galloyltricetifavan: a promising natural radical scavenger

“…7-O-Galloyltricetifavan (7OGT; figure 1), a natural flavonoid, was first isolated from the leaves of Pithecellobium clypearia [1][2][3]. 7OGT is a flavan derivative that has antiviral properties against respiratory syncytial virus, influenza H1N1 virus, herpes simplex virus type 1 and coxsackie B3 virus as well as anti-inflammatory, anti-Alzheimer, anti-allergic and antioxidant properties [1][2][3][4][5][6][7]. Studies showed that 7OGT has potent xanthine oxidase inhibition with an IC 50 = 25.5 µmol l −1 [3] and inhibits soluble epoxide hydrolase enzymatic activity with IC 50 values 10.0 ± 0.4 µM [5].…”

“…7OGT is a flavan derivative that has antiviral properties against respiratory syncytial virus, influenza H1N1 virus, herpes simplex virus type 1 and coxsackie B3 virus as well as anti-inflammatory, anti-Alzheimer, anti-allergic and antioxidant properties [1][2][3][4][5][6][7]. Studies showed that 7OGT has potent xanthine oxidase inhibition with an IC 50 = 25.5 µmol l −1 [3] and inhibits soluble epoxide hydrolase enzymatic activity with IC 50 values 10.0 ± 0.4 µM [5]. Thus, 7OGT is indicated as a good natural antioxidant with the known neuroprotective activity that is believed to underpin the prevention of Alzheimer's disease [7].…”