Soluble Fas and gonadal hormones in infertile men with varicocele

Zedan, Hatem; El-Mekhlafi, Abdel Wasea M.M.; El-Noweihi, Amira M.; Elazim, Nagwa Essa Abd; Mostafa, Taymour

doi:10.1016/j.fertnstert.2007.11.090

Cited by 27 publications

(18 citation statements)

References 57 publications

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“…It is suggested that sFas may be a marker of overall apoptosis triggering, at the same time regulating apoptosis by competing with the cell surface receptor. Previous reports have suggested that the Fasmediated system is implicated in the elimination of defective spermatozoa from the ejaculate and shows possible irregularities that could account for certain forms of male infertility (10)(11)(12).…”

Section: Introductionmentioning

confidence: 99%

Apoptotic markers in semen of infertile men: association with cigarette smoking

El-Melegy

Ali

2011

Int. braz j urol.

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Objectives: (i) To examine the role of apoptosis in the pathogenesis of DNA damage in semen from infertile men. (ii) To assess the effects of smoking on apoptotic markers and seminal parameters among infertile men. (iii) To assess the correlation of apoptosis with conventional semen parameters. Materials and Methods:The study was carried out on 70 men with idiopathic infertility, divided into two groups: thirty infertile non smokers and forty infertile smokers. In addition to 60 fertile men (30 non smokers and 30 smokers) as control group. Each subject provided semen for analysis of parameters, determination of % of DNA fragmentation, s-Fas, caspase-3 activity levels and cotinine levels. Results:The results revealed that infertile men, particularly smokers have significantly lower semen variables and significantly higher levels of apoptotic variables (% of DNA fragmentation, s-Fas and caspase-3 activity) in addition to cotinine. Conclusions:The present findings provide additional evidence supporting the importance of the evaluation of apoptotic markers to test male infertility particularly among smokers.

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Section: Introductionmentioning

confidence: 99%

Apoptotic markers in semen of infertile men: association with cigarette smoking

El-Melegy

Ali

2011

Int. braz j urol.

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“…It is suggested that the spermatogenic dysfunction in varicocele testis may be related partly to an abnormal control of apoptosis [13,61,62]. Apoptosis, or signal-induced cell death, is a process in which a genetic mechanism, responsible for a series of events related to morphologic and biochemical changes, initiates by certain stimuli and culminates in the death of a cell.…”

Section: Varicocele and Apoptosismentioning

confidence: 99%

“…In the testis, Fas may be found in spermatogenic germ cells, and Fas-L in Sertoli cells [13,69,71]. It seems that the Fas/Fas L system is a major regulator of normal spermatogenesis [72].…”

Section: Varicocele and Apoptosismentioning

confidence: 99%

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Immunological Aspects of Varicocele

R¹

2015

MOJI

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Varicocele is the most common cause of infertility in men. The mechanism by which varicocele cause the variable effect on male infertility and is still unknown. Varicocele is found in 35 to 81 % of infertile men, and is one treatable form of male infertility. Although many advances have occurred in the treatment of varicocele, it still represents an important and challenging aspect of basic research (male reproductive physiology and endocrinology, pathophysiology, and pharmacology of reproduction and fertility) and medical practice for urologists, pediatric surgeons, and general physicians, to date. This review provides an overview of the epidemiology, Clinical classification and Immunological aspects of varicocele and discusses the indications for, and interpretation of Immunological aspects of varicocele.

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“…Numerous studies have shown a relationship between apoptosis markers and male infertility 53 . Phosphatidylserine externalization and DNA fragmentation were shown to occur more frequently in spermatozoa that were positive for active caspase-3.…”

Section: Apoptosis and Male Fertilitymentioning

confidence: 99%

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2015

IJPSR

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Soluble Fas and gonadal hormones in infertile men with varicocele

Cited by 27 publications

References 57 publications

Apoptotic markers in semen of infertile men: association with cigarette smoking

Apoptotic markers in semen of infertile men: association with cigarette smoking

Immunological Aspects of Varicocele

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