Soluble Fiber Supplementation and Serum Lipid Profile: A Systematic Review and Dose-Response Meta-Analysis of Randomized Controlled Trials

Ghavami, Abed; Ziaei, Rahele; Barghchi, Hanieh; Nattagh‐Eshtivani, Elyas; Moradi, Sajjad; Rahbarinejad, Pegah; Mohammadi, Hamed; Tehrani, Hatav Ghasemi; Marx, Wolfgang; Askari, Gholamreza

doi:10.1016/j.advnut.2023.01.005

Cited by 24 publications

(26 citation statements)

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“…Reducing TC, TG, and LDL‐C and increasing HDL‐C levels are strategies for both main and secondary CVD protection (Zodda et al, 2018). Consequently, many studies have been conducted in order to investigate alternative and complementary therapies in this field (Bahari, Taheri, Rashidmayvan, Hezaveh, et al, 2023; Ghavami et al, 2023; Mohammadi et al, 2021; Nattagh‐Eshtivani, Pahlavani, et al, 2022; Salehi‐Sahlabadi et al, 2020). The aim of the present research was to gather the results of randomized controlled studies on the effectiveness of sumac supplementation on lipid levels.…”

Section: Discussionmentioning

confidence: 99%

“…All data were reported as mean differences with Standard Deviation (SD). Hozo et al (2005) method and the SD calculation formula (Standard Error of Mean [SEM]) (Ghavami et al, 2023) were used to calculate the mean and SD, respectively, if data were published in median and range (or 95% CI) or SEM. I ‐square ( I 2 ) test and subgroup analysis, including intervention duration <12 versus ≥12 weeks, intervention dose of <3 versus ≥3 gm per day, and gender (male, female, and both), was performed to determine between‐study heterogeneity.…”

Section: Methodsmentioning

confidence: 99%

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Effects of sumac supplementation on lipid profile: A systematic review and meta‐analysis of randomized controlled trials

Bahari,

Taheri,

Namkhah

et al. 2023

Phytotherapy Research

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This systematic review aimed to gather data on the effects of sumac supplementation on lipid profile. A systematic literature search was carried out using electronic databases (PubMed, Scopus, and Web of Science) up to March 2023 to identify eligible randomized controlled trials (RCTs) assessing the effects of sumac intake on lipid profile as an outcome. All participants enrolled in our study were adult individuals who consumed sumac, in various forms, as an intervention. The included articles were assessed using the Cochrane risk of bias assessment tool. Heterogeneity tests of the selected trials were performed using the I2 statistic. Random effects models were assessed based on the heterogeneity tests, and pooled data were determined as the weighted mean difference with a 95% confidence interval. In total, seven RCTs with a total sample size of 570 subjects were included. This study found a significant decrease in total cholesterol (TC) (weighted mean difference [WMD]: −10.01 mg/dL; 95% CI: −18.67, −1.34), triglyceride (TG) (WMD: −8.52 mg/dL; 95% CI: −14.79, −2.25), and low‐density lipoprotein (LDL)‐C levels (WMD: −9.25 mg/dL; 95% CI: −14.56, −3.93); Moreover, a significant increase was observed in high‐density lipoprotein (HDL)‐C concentration (WMD: 2.97 mg/dL; 95% CI: 0.75, 5.19). The reduction in TG and TC was greater in studies with a duration of ≥12 compared to <12 weeks. The increase in HDL‐C was greater in participants with an intervention duration of ≥12 compared to <12 weeks. Moreover, subgroup analysis based on the dose of sumac suggested a significant reduction in TC and LDL, specifically for doses below 3 g. Consumption of sumac significantly decreased serum TC, LDL‐C, and TG concentrations. This study suggested significantly positive effects on HDL‐C by intake of sumac. Longer interventions (>12 weeks) have a more favorable impact on TC, LDL‐C, and HDL‐C, while sumac doses below 3 g/day show greater effects on TC and LDL‐C. These findings underscore the potential of sumac supplementation as a valuable approach to lipid profile management.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Effects of sumac supplementation on lipid profile: A systematic review and meta‐analysis of randomized controlled trials

Bahari,

Taheri,

Namkhah

et al. 2023

Phytotherapy Research

Self Cite

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show abstract

“…The main limitation is that each treatment phase was only three weeks, so the study cannot provide information about the persistence of the effect over longer periods, as well as adherence to daily consumption of the quantities consumed. However, prior studies with viscous dietary fibers have shown that the cholesterol-lowering effect persists over longer periods ( 11 , 13 ).…”

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confidence: 99%

“…One type of dietary intervention that has been found to lower the LDL-C concentration is consumption of foods or supplements containing viscous dietary fibers. The primary proposed mechanism for the cholesterol-lowering effects of viscous fibers is trapping of bile acids and cholesterol, which reduces absorption and reabsorption of these substances ( 11 - 13 ). Reduced absorption results in lower levels of cholesterol and bile acids in hepatocytes, triggering up-regulation of hepatic LDL receptors that remove apolipoprotein B-containing lipoproteins, including LDL particles, from the blood, thus lowering the circulating level of LDL-C ( 10 , 14 ).…”

mentioning

confidence: 99%

“…Reduced absorption results in lower levels of cholesterol and bile acids in hepatocytes, triggering up-regulation of hepatic LDL receptors that remove apolipoprotein B-containing lipoproteins, including LDL particles, from the blood, thus lowering the circulating level of LDL-C ( 10 , 14 ). The fermentability of dietary fibers may play a smaller, secondary role in the cholesterol-lowering effect of fiber, although the evidence for this is mixed ( 13 , 15 ).…”

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confidence: 99%

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