Soluble fibre supplementation with and without a probiotic in adults with asthma: A 7-day randomised, double blind, three way cross-over trial

McLoughlin, Rebecca F.; Berthon, Bronwyn S.; Rogers, Geraint B.; Baines, Katherine J.; Leong, Lex E. X.; Gibson, Péter G.; Williams, Evan J.; Wood, Lisa G.

doi:10.1016/j.ebiom.2019.07.048

Cited by 85 publications

(58 citation statements)

References 74 publications

(105 reference statements)

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“…Supplementation of 12 g/d of sc-inulin to asthmatic adults showed increased relative abundance of Anaerostipes and a trend for that of Bifidobacterium, while Roseburia and Erysipelotrichaceae relative abundances decreased (McLoughlin et al, 2019). Post-hoc group analyses showed an improvement in asthma control and airway inflammation for the sc-inulin treatment compared to control and to a synbiotic treatment, and the changes in Anaerostipes and Roseburia were associated with these effects.…”

Section: Beneficial Microbes 11(2) 109mentioning

confidence: 89%

Effect of fructans, prebiotics and fibres on the human gut microbiome assessed by 16S rRNA-based approaches: a review

Swanson

Vos

Martens

et al. 2020

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The inherent and diverse capacity of dietary fibres, nondigestible oligosaccharides (NDOs) and prebiotics to modify the gut microbiota and markedly influence health status of the host has attracted rising interest. Research and collective initiatives to determine the composition and diversity of the human gut microbiota have increased over the past decade due to great advances in high-throughput technologies, particularly the 16S ribosomal RNA (rRNA) sequencing. Here we reviewed the application of 16S rRNA-based molecular technologies, both community wide (sequencing and phylogenetic microarrays) and targeted methodologies (quantitative PCR, fluorescent in situ hybridisation) to study the effect of chicory inulin-type fructans, NDOs and specific added fibres, such as resistant starches, on the human intestinal microbiota. Overall, such technologies facilitated the monitoring of microbiota shifts due to prebiotic/fibre consumption, though there are limited community-wide sequencing studies so far. Molecular studies confirmed the selective bifidogenic effect of fructans and galactooligosaccharides (GOS) in human intervention studies. Fructans only occasionally decreased relative abundance of Bacteroidetes or stimulated other groups. The sequencing studies for various resistant starches, polydextrose and beta-glucan showed broader effects with more and different types of gut microbial species being enhanced, often including phylotypes of Ruminococcaceae. There was substantial variation in terms of magnitude of response and in individual responses to a specific fibre or NDO which may be due to numerous factors, such as initial presence and relative abundance of a microbial type, diet, genetics of the host, and intervention parameters, such as intervention duration and fibre dose. The field will clearly benefit from a more systematic approach that will support defining the impact of prebiotics and fibres on the gut microbiome, identify biomarkers that link gut microbes to health, and address the personalised response of an individual’s microbiota to prebiotics and dietary fibres.

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Section: Beneficial Microbes 11(2) 109mentioning

confidence: 89%

Effect of fructans, prebiotics and fibres on the human gut microbiome assessed by 16S rRNA-based approaches: a review

Swanson

Vos

Martens

et al. 2020

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“…Dietary fibre resists digestion in the small intestine and upon reaching the colon, soluble forms are partially fermented by commensal bacteria. Some soluble fibres act as prebiotics, providing a selective growth substrate, leading to changes in bacterial number and diversity and increased production of immunosuppressive by-products 21 , which have been shown to reduce airway inflammation in both animal 83 and humans 84 , 85 models of asthma. Hence, increasing fibre intake in COPD may be a relevant therapeutic strategy, as previously suggested 26 .…”

Section: Discussionmentioning

confidence: 99%

Disease-associated gut microbiome and metabolome changes in patients with chronic obstructive pulmonary disease

et al. 2020

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Chronic obstructive pulmonary disease (COPD) is the third commonest cause of death globally, and manifests as a progressive inflammatory lung disease with no curative treatment. The lung microbiome contributes to COPD progression, but the function of the gut microbiome remains unclear. Here we examine the faecal microbiome and metabolome of COPD patients and healthy controls, finding 146 bacterial species differing between the two groups. Several species, including Streptococcus sp000187445, Streptococcus vestibularis and multiple members of the family Lachnospiraceae, also correlate with reduced lung function. Untargeted metabolomics identifies a COPD signature comprising 46% lipid, 20% xenobiotic and 20% amino acid related metabolites. Furthermore, we describe a disease-associated network connecting Streptococcus parasanguinis_B with COPD-associated metabolites, including N-acetylglutamate and its analogue N-carbamoylglutamate. While correlative, our results suggest that the faecal microbiome and metabolome of COPD patients are distinct from those of healthy individuals, and may thus aid in the search for biomarkers for COPD.

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“…Children with high amounts of butyrate and propionate in feces at 1 year of age have significantly less atopic sensitization and are less likely to have asthma between 3 and 6 years (Roduit et al, 2019). Moreover, soluble fiber supplementation has been found to decrease sputum eosinophilia and sputum histone deacetylase 9 gene expression in asthma patients (McLoughlin et al, 2019). In mice, SCFAs have been shown to increase the expression of the transcription factor FOXP3 via inhibition of histone deacetylation, thereby supporting the expansion of T regulatory cells (Tregs), and increasing the production of IL-10 ( Arpaia et al, 2013).…”

Section: Bacteria Are the Largest Microbial Population In The Gut Andmentioning

confidence: 99%

The Role of Lung and Gut Microbiota in the Pathology of Asthma

et al. 2020

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Soluble fibre supplementation with and without a probiotic in adults with asthma: A 7-day randomised, double blind, three way cross-over trial

Cited by 85 publications

References 74 publications

Effect of fructans, prebiotics and fibres on the human gut microbiome assessed by 16S rRNA-based approaches: a review

Effect of fructans, prebiotics and fibres on the human gut microbiome assessed by 16S rRNA-based approaches: a review

Disease-associated gut microbiome and metabolome changes in patients with chronic obstructive pulmonary disease

The Role of Lung and Gut Microbiota in the Pathology of Asthma

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