Soluble ICAM-1 in primary biliary cirrhosis (PBC) during combined treatment with ursodeoxycholic acid, prednisone and azathioprine

Based on very low quality evidence, there is currently no evidence that any intervention is beneficial for primary biliary cholangitis. However, the follow-up periods in the trials were short and there is significant uncertainty in this issue. Further well-designed randomised clinical trials are necessary. Future randomised clinical trials ought to be adequately powered; performed in people who are generally seen in the clinic rather than in highly selected participants; employ blinding; avoid post-randomisation dropouts or planned cross-overs; should have sufficient follow-up period (e.g. five or 10 years or more); and use clinically important outcomes such as mortality, health-related quality of life, cirrhosis, decompensated cirrhosis, and liver transplantation. Alternatively, very large groups of participants should be randomised to facilitate shorter trial duration.

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Soluble ICAM-1 in primary biliary cirrhosis (PBC) during combined treatment with ursodeoxycholic acid, prednisone and azathioprine

Cited by 3 publications

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Glucocorticosteroids for primary biliary cirrhosis

Glucocorticosteroids for primary biliary cirrhosis

Azathioprine for primary biliary cirrhosis

Pharmacological interventions for primary biliary cholangitis

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