Soluble Intercellular Adhesion Molecule-1 Concentrations in Patients with Subacute Thyroiditis and in Patients with Graves' Disease with or without Ophthalmopathy.

Özata, Metịn; Bolu, Erol; Şengül, Ali; Altinsoy, H I; Turan, Mustafa; Çorakçı, Ahmet; Hacibektaşoğlu, A; Gundogan, M. Ali

doi:10.1507/endocrj.43.517

Cited by 16 publications

(6 citation statements)

References 32 publications

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“…In one study, the mean sICAM-1 concentration in patients with hypothyroidism due to chronic thyroiditis was significantly elevated versus control subjects and not different from untreated hyperthyroid patients [40]. Other authors reported an increase in sICAM-1 levels in both hyperthyroidism and hypothyroidism, while patients with euthyroid nodular goiter were within the normal range [41].…”

Section: Discussionmentioning

confidence: 93%

Insulin sensitivity, plasma adiponectin and sICAM-1 concentrations in patients with subclinical hypothyroidism: response to levothyroxine therapy

et al. 2011

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Subclinical hypothyroidism is associated with an increased risk of atherosclerosis. The aim of this study was to investigate the concentration of plasma soluble intercellular adhesion molecule-1 and adiponectin in relation to insulin sensitivity in patients with subclinical hypothyroidism and to estimate if L-thyroxine treatment had an influence on these parameters. 13 women with subclinical hypothyroidism and 14 euthyroid controls were included in the study. A physical examination was conducted, hyperinsulinemic euglycemic clamp and plasma soluble intercellular adhesion molecule-1, adiponectin and lipids profiles were measured at baseline in both groups and in the group with subclinical hypothyroidism the above procedures were performed after L-thyroxine therapy (mean time of treatment 5.0 months) in stable euthyroid state. Insulin sensitivity and adiponectin were not different at baseline in the two studied groups. Plasma soluble intercellular adhesion molecule-1 concentration was significantly higher in the patients with subclinical hypothyroidism (P = 0.011). The comparison of lipids profiles revealed that only LDL-cholesterol concentration was higher (P = 0.011) in the group with subclinical hypothyroidism. After therapy, we observed an improvement of insulin sensitivity (P = 0.012) and a decrease of plasma glucose (P = 0.019) and soluble intercellular adhesion molecule-1 (P = 0.01), whereas adiponectin concentration remained unchanged. We concluded that L-thyroxine treatment in patients with subclinical hypothyroidism might exert a beneficial effect by reducing cardiovascular risk factors.

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Section: Discussionmentioning

confidence: 93%

Insulin sensitivity, plasma adiponectin and sICAM-1 concentrations in patients with subclinical hypothyroidism: response to levothyroxine therapy

et al. 2011

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“…This overlap was not found in earlier studies. In the case of sICAM‐1, this might have been caused by selection of patients and controls [8], because less overlap may be expected if controls are predominantly non‐smokers as opposed to smoking patients who, because they smoke, may also have more severe GO [7,9,20]. In the group of Graves’ thyroid disease patients without GO, the difference between smokers and non‐smokers was less marked, probably because of small sample size.…”

Section: Discussionmentioning

confidence: 99%

“…Soluble forms of these adhesion molecules can be measured in serum, and several studies report that patients with GO have higher levels of sICAM‐1 and sELAM‐1 in serum than patients with Graves’ disease without GO or healthy controls [7–9]. This has attracted our attention, because a serum marker for GO would be very helpful.…”

Section: Introductionmentioning

confidence: 99%

Smoking and disease severity are independent determinants of serum adhesion molecule levels in Graves’ ophthalmopathy

Wakelkamp

Gerding

Meer

et al. 2002

Clinical and Experimental Immunology

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SUMMARY Adhesion molecules play a key role in autoimmune disorders, and serum concentrations of soluble adhesion molecules are increased in Graves’ ophthalmopathy (GO). Whether this is due to the strong association with smoking is unknown. It is also not known if the severity or activity of GO determine the serum levels of adhesion molecules. We measured serum concentrations of sICAM‐1, sVCAM‐1 and sELAM‐1 in 62 euthyroid Graves’ patients with untreated GO, in 62 healthy controls matched for sex, age and smoking habits, and in 26 euthyroid Graves’ patients without GO. GO severity was assessed by the Total Eye Score and the activity by the Clinical Activity Score. Adhesion molecules were measured by highly sensitive ELISAs. GO patients had higher levels than controls (median values in ng/ml with range): sICAM‐1 300 [171–575] versus 244 [119–674], P < 0·001; sVCAM‐1 457 [317–1060] versus 410 [238–562], P < 0·001; and sELAM‐1 61 [19–174] versus 53 [23–118], P = 0·021. Euthyroid Graves’ disease patients without GO had levels similar to controls: sICAM‐1 273 138–453), sVCAM‐1 386 [260–1041] and sELAM‐1 46 [22–118]. Smoking had an independent effect and was associated with higher levels of sICAM‐1 and lower levels of sVCAM‐1 in both GO patients and controls; sELAM‐1 levels were comparable. In the 62 GO patients, sICAM‐1 correlated significantly with severity of eye disease (r = 0·40, P = 0·002). No correlation was found with the duration of GO, the Clinical Activity Score or TBII levels. Multivariate analysis of all 150 subjects showed that the presence of GO and smoking are independent determinants of sICAM‐1 and sVCAM‐1 concentrations. In GO patients, the Total Eye Score was a stronger determinant than smoking. It is concluded that (i) smoking is associated with increased sICAM‐1 and decreased sVCAM‐1 levels; (ii) independent from smoking, euthyroid GO patients have higher levels of sICAM‐1, sVCAM‐1 and sELAM‐1 than patients with euthyroid Graves’ disease or healthy controls; (iii) the major determinant of sICAM‐1 in GO patients is the severity of their eye disease.

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“…Die prim~iren Zielstrukturen des autoreaktiven Immunsystems im Orbitagewebe und die pathogenetischen Zu-sammenh~inge zwischen endok¡ Orbitopathie und autoimmuner Thyreopathie sind bislang unbekannt. Ebenso ist das 16sliche Adhiisionsmolekª ICAM-I in Seren vermehrt nachweisbar, wie in einer Studie mit 130 Patienten gezeigt werden konnte [13], und spiegelt unabhlin~g von der Schilddrª den Grad der orbitalen Entzª vit~t wider [23,56]. Verschiedene immunotaktische Komponenten, wie das Adh~isionsprotein ICAM-1, Hitzeschockproteine und die Expression von HLA-DR-Antigenen lassen sich retrobulbfir nachweisen [1].…”

Section: Abbildung 2aunclassified

Endokrine Orbitopathie 1998

Forster

Kahaly

1998

Med Klin

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Soluble Intercellular Adhesion Molecule-1 Concentrations in Patients with Subacute Thyroiditis and in Patients with Graves' Disease with or without Ophthalmopathy.

Cited by 16 publications

References 32 publications

Insulin sensitivity, plasma adiponectin and sICAM-1 concentrations in patients with subclinical hypothyroidism: response to levothyroxine therapy

Insulin sensitivity, plasma adiponectin and sICAM-1 concentrations in patients with subclinical hypothyroidism: response to levothyroxine therapy

Smoking and disease severity are independent determinants of serum adhesion molecule levels in Graves’ ophthalmopathy

Endokrine Orbitopathie 1998

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