Soluble LR11 is a novel biomarker for vascular lesions late after Kawasaki disease

Watanabe, Kenichi; Sano, Hiroshi; Jiang, Meizi; Haniu, Hisanori; Numano, Fujito; Hoshina, Satoshi; Saitoh, Akihiko; Uchiyama, Makoto; Bujo, Hideaki

doi:10.1016/j.atherosclerosis.2015.12.035

Cited by 3 publications

(3 citation statements)

References 22 publications

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“…The serum LR11 concentration measured by same method was reported around 10 ng/mL in most healthy individuals 7,8) ; thus, we divided the patients into a low LR11 group (LR11 levels below 10 ng/mL) and a high LR11 group (LR11 levels of 10 ng/mL or higher) and compared the two groups.…”

Section: Methodsmentioning

confidence: 99%

Examination of a Low-density Lipoprotein Receptor Relative with 11 Ligand-binding Repeats (LR11) as a Biomarker in Esophageal Cancer

Uchida

Nasu

Hashimoto

et al. 2022

Juntendo Medical Journal

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Objectives: Some previous studies reported that the levels of a low-density lipoprotein receptor relative with 11 ligand-binding repeats (LR11) was a prognostic marker in some malignant tumors; however, whether LR11 is related to survival in patients with esophageal cancer remains unclear.Methods: In this study, we measured LR11 in the preoperative serum of 46 patients of esophageal cancer who undergoing surgery using a sandwich enzyme-linked immunosorbent assay (ELISA) method with anti-LR11 monoclonal antibodies. We investigated the correlation between the level of LR11 and survival of patients with esophageal cancer. Clinicopathological data were retrospectively retrieved from our institution's database. Results: The patients were divided into two groups (low LR11 and high LR11) based on the level of LR11. There was no statistical difference in clinicopathological factors between these two groups. The low LR11 group had a significantly longer overall survival than the high LR11 group.Conclusions: LR11 can be measured with a relatively simple ELISA and is potentially a new prognostic marker for esophageal cancer.

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Section: Methodsmentioning

confidence: 99%

Examination of a Low-density Lipoprotein Receptor Relative with 11 Ligand-binding Repeats (LR11) as a Biomarker in Esophageal Cancer

Uchida

Nasu

Hashimoto

et al. 2022

Juntendo Medical Journal

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“…sLR11 could, therefore, be a novel biomarker for vascular lesions long after KD. 15 However, the role of sLR11 in acute KD patients remains unknown. duction differs from that of other biomarkers.…”

Section: Sensitivity and Specificity Of Slr11 Levels In Predicting Responsiveness To Ivig Therapymentioning

confidence: 99%

“…This is consistent with our previous report that focused on sLR11 long after KD. 15 In addition, LR11 is also reported to be expressed in peripheral leukocytes, especially CD14 + monocytes. 21 sLR11 may be derived from leukocytes, especially in the hyperacute phase before vasculitis.…”

Section: Sensitivity and Specificity Of Slr11 Levels In Predicting Responsiveness To Ivig Therapymentioning

confidence: 99%

Soluble LR11 as a Novel Biomarker in Acute Kawasaki Disease

Watanabe

Sano

Jiang

et al. 2022

Circ J

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Histological results reveal that coronary arteritis begins 6-8 days after onset and progresses to pan-vasculitis on approximately day 10 of acute KD. Aneurysms develop on or around day 12, and are accompanied by destruction of the internal elastic lamina and media. 5 Smooth muscle cells (SMCs) are observed in the intima in acute KD vasculitis and are considered to contribute to vasculitis progression. 6 LR11, which is a member of the low-density lipoprotein (LDL) receptor family, is markedly expressed in vascular SMCs that are present in the intima of atherosclerotic K awasaki disease (KD) is an acute, self-limited generalized systemic vasculitis that is most common in children under 5 years of age. Although more than 50 years have passed since KD was first reported by Dr. Tomisaku Kawasaki in 1967, 1 its etiology remains unknown. KD causes inflammation in the walls of medium-sized arteries, particularly the coronary artery. Coronary artery lesions (CALs) occur in 20-25% of untreated KD patients, and include aneurysms, stenosis, and occlusion, which are its most critical complications. These critical complications may lead to myocardial infarction or cardiac death. 2,3 KD is the leading cause of acquired heart disease among children in developed countries. 4Editorial p ????

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Insights Into Coronary Artery Lesions in Kawasaki Disease

et al. 2020

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This review summarizes recent advances in understanding the development of coronary arteritis in Kawasaki disease. Kawasaki disease is the most common cause of acquired heart disease among children characterized with coronary artery abnormalities, which can cause myocardial ischemia, infarction, and even death. The pathogenic factors of Kawasaki disease and the pathological process of coronary artery disease are not clear at present, which brings challenges to the prevention and treatment of the disease. The treatment of Kawasaki disease focuses mainly on timely administration of intravenous high doses of immunoglobulin and aspirin. However, there are still some patients who do not respond well to this standard treatment, and its management remains a challenge. As a result, coronary artery lesions still occur in patients and affect their quality of life. In this review, we discuss updated research data of Kawasaki disease coronary artery lesions.

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Soluble LR11 is a novel biomarker for vascular lesions late after Kawasaki disease

Cited by 3 publications

References 22 publications

Examination of a Low-density Lipoprotein Receptor Relative with 11 Ligand-binding Repeats (LR11) as a Biomarker in Esophageal Cancer

Examination of a Low-density Lipoprotein Receptor Relative with 11 Ligand-binding Repeats (LR11) as a Biomarker in Esophageal Cancer

Soluble LR11 as a Novel Biomarker in Acute Kawasaki Disease

Insights Into Coronary Artery Lesions in Kawasaki Disease

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