2008
DOI: 10.1164/rccm.200802-258oc
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Soluble Mesothelin-related Protein in an Asbestos-exposed Population

Abstract: This is the first large-scale prospective study of SMRP for screening for malignancy in asbestos-exposed individuals. A high false-positive rate was observed. SMRP seems unlikely to prove useful in screening for MM.

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Cited by 99 publications
(85 citation statements)
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“…However, currently few cases of MM are detected at an early stage and histological confirmation was important as a gold standard for our study. Ideally, a prospective study design would be employed in screening an asbestos-exposed cohort, similar to work which has been performed with other biomarkers [39]. When initial case-controlled studies are translated into prospective cohort screening studies, diagnostic accuracy usually falls.…”
Section: Discussionmentioning
confidence: 99%
“…However, currently few cases of MM are detected at an early stage and histological confirmation was important as a gold standard for our study. Ideally, a prospective study design would be employed in screening an asbestos-exposed cohort, similar to work which has been performed with other biomarkers [39]. When initial case-controlled studies are translated into prospective cohort screening studies, diagnostic accuracy usually falls.…”
Section: Discussionmentioning
confidence: 99%
“…In this series neither CYFRA 21.1 nor CA 125 were more useful for mesothelioma early diagnosis. In a recent paper Park et al investigated a cohort of 538 asbestos exposed subjects and concluded that serum mesothelin is slightly but significantly increased in patients with pleural plaques secondary to asbestos exposure compared with healthy asbestos exposed controls [81]. However no malignant mesothelioma was detected despite the fact that 15 patients (i.e.…”
Section: Mesothelinmentioning
confidence: 99%
“…However, it was not feasible to discriminate healthy asbestos-exposed individuals from those with benign pleural and pulmonary disorders by using SMRP measurement. Previous studies indicated the possibility of SMRP to screen cases with pleural and lung disorders in asbestos-exposed population, although the efficiency of SMRP-based screening approach needs further investigation in prospective cohort studies [6,8,19,[26][27][28]. In these studies, few had evaluated the potential confounders influencing the value of SMRP [26][27][28].…”
Section: Discussionmentioning
confidence: 99%
“…Accumulating evidence indicate that SMRP is a candidate molecule investigated in health surveillance of workers exposed to asbestos, and is considered as a promising biomarker useful for early diagnosis and monitoring the progress of ARDs [4][5][6][7]. Given the high falsepositive of SMRP in a large-scale prospective study of SMRP for screening for ARDs in asbestos-exposed individuals [8], it is imperative to investigate the potential factors influencing the SMRP concentrations in subjects with a history of asbestos exposure. Recent studies showed that demographic variables, physiological factors, and genetic modification effects were associated with SMRP concentration [9][10][11][12].…”
Section: Introductionmentioning
confidence: 99%