2021
DOI: 10.1016/j.jobcr.2021.02.010
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Soluble neuropilin-1 in gingival crevicular fluid is associated with rheumatoid arthritis: An exploratory case-control study

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Cited by 10 publications
(6 citation statements)
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“…Sema3A was found to be significantly elevated in groups P and G than group H. Studies around implants 37 and teeth 38 reported increased gene expression of Sema3A in peri‐implantitis sites 37 and increased GCF Sema3A receptor (neuropilin‐1; Nrp‐1) levels in periodontitis stages III and IV. Increased GCF Nrp‐1 levels were also reported in RA patients, compared with controls 39 . However, one cross‐sectional periodontal study reported contradictory results 40 .…”
Section: Discussionmentioning
confidence: 98%
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“…Sema3A was found to be significantly elevated in groups P and G than group H. Studies around implants 37 and teeth 38 reported increased gene expression of Sema3A in peri‐implantitis sites 37 and increased GCF Sema3A receptor (neuropilin‐1; Nrp‐1) levels in periodontitis stages III and IV. Increased GCF Nrp‐1 levels were also reported in RA patients, compared with controls 39 . However, one cross‐sectional periodontal study reported contradictory results 40 .…”
Section: Discussionmentioning
confidence: 98%
“…Increased GCF Nrp-1 levels were also reported in RA patients, compared with controls. 39 However, one cross-sectional periodontal study reported contradictory results. 40 Despite these mostly consistent findings of elevated Sema3A (or its receptor) levels in diseased gingival tissues, Sema3A levels were not correlated with periodontal clinical parameters in the present study and did not change following non-surgical periodontal treatment.…”
Section: Discussionmentioning
confidence: 99%
“…AD is an inflammatory skin condition sustained by genetic mutations, environmental factors, and an altered immune status. Previous studies have demonstrated that GCF is a suitable and non-invasive sampling procedure that shows different profiles in individuals with chronic pathologies compared with controls [29][30][31][32][33][34], while the GCF profile in individuals with AD remains elusive. In our study, we determined for the first time that AD individuals have higher levels of IL-31 and TSLP in GCF than controls.…”
Section: Discussionmentioning
confidence: 99%
“…A study suggested that molecules from systemic diseases can travel to the oral gingiva, modifying the immune composition of the GCF [29]. Prior studies using multiplex-bead immunoassays and ELISA methods have uncovered distinct GCF profiles between systemically healthy subjects and those with acute myocardial infarction, diabetes, rheumatoid arthritis, and psoriasis [29][30][31][32][33][34]. However, this aspect has yet to be comprehensively evaluated in AD.…”
Section: Introductionmentioning
confidence: 99%
“… 22 Also, another study found that participants with rheumatoid arthritis and periodontitis had significantly higher levels of sNRP-1 in GCF. 23 …”
Section: Introductionmentioning
confidence: 99%