Soluble polymeric carriers for drug delivery. Part 2. Preparation and in vivo behaviour of N-acylethylenimine copolymers

Goddard, Peter; Hutchinson, Lusie E.F.; Brown, Janet; Brookman, L.

doi:10.1016/0168-3659(89)90013-8

Cited by 97 publications

(52 citation statements)

References 14 publications

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“…P(MOx) can be regarded as alternative to PEO due to its hydrophilicity, 24 biocompatibility, and low toxicity which made it an 3 appropriate candidate for biomedical applications. [25][26][27][28][29][30] On the other hand, hydrophobic P(t-BA) can be easily functionalized by trans-esterification 31 or converted into biocompatible hydrophilic poly(acrylic acid). 32 The P(MOx) and P(t-BA) building blocks were synthesized by CROP and ATRP processes, respectively.…”

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confidence: 99%

Well‐defined poly(oxazoline)‐b‐poly(acrylate) amphiphilic copolymers: From synthesis by polymer–polymer coupling to self‐organization in water

Guillerm

Monge

Lapinte

et al. 2012

J. Polym. Sci. A Polym. Chem.

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In this contribution, we report on the self assembly in water of original amphiphilic poly(2-methyl-2-oxazoline)-b-poly(tert-butyl acrylate) copolymers, synthesized by copper catalyzed azide-alkyne cycloaddition (CuAAC) reaction. For such purpose, polyoxazoline (poly(2-methyl-2-oxazoline)) and polyacrylate (poly(tert-butyl acrylate)) are first prepared by cationic ring-opening polymerization (CROP) and atom transfer radical polymerization (ATRP), respectively. Well-defined polymeric building blocks, ω-N 3 -P(t-BA) and -alkyne-P(MOx), bearing reactive chain end groups, are accurately characterized by MALDI-Tof spectroscopy. Then, P(MOx) n -b-P(t-BA) m are achieved by polymer-polymer coupling and are fully characterized by DOSY NMR and size exclusion chromatography, demonstrating the obtaining of pure amphiphilic copolymers. Consequently, the latter lead to the formation in water of well-defined monodisperse spherical micelles (R H = 40-60 nm) which are studied by fluorescence spectroscopy, SLS, AFM and TEM.

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confidence: 99%

Well‐defined poly(oxazoline)‐b‐poly(acrylate) amphiphilic copolymers: From synthesis by polymer–polymer coupling to self‐organization in water

Guillerm

Monge

Lapinte

et al. 2012

J. Polym. Sci. A Polym. Chem.

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“…Fmoc has been used for its self-assembly and fluorescence properties but we envisage that it could be replace by a more biocompatible aromatic functionality still able to develop interesting self-assembly interactions through π-π stacking, e.g., fully peptidic self-assembly moieties [27]. The development of such a system could lead to application in the drug delivery field due to the low cytotoxicity profiles showed by POx family [28][29][30] and the "switchability" introduced by enzyme catalysis.…”

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confidence: 99%

A Systematic Study on the Self-Assembly Behaviour of Multi Component Fmoc-Amino Acid-Poly(oxazoline) Systems

Caponi

Ulijn

2012

Polymers

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Abstract:We report a systematic study of a modular approach to create multi-component supramolecular nanostructures that can be tailored to be both enzyme and temperature responsive. Using a straightforward synthetic approach we functionalised a thermal responsive polymer, poly(2-isopropyl-2-oxazoline), with fluorenylmethoxycarbonyl-amino acids that drive the self-assembly. Depending on the properties of appended amino acids, these polymers undergo substantial morphological changes in response to the catalytic action of alkaline phosphatase.

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“…PEOZ is soluble in water and in many organic solvents [92]. Like PEG, PEOZ can be synthesized with low polydispersity and can have a single functional group at one extreme, useful for protein conjugation, which is obtained during the initiation [93][94][95] or termination [96,97] steps of polymerization.…”

Section: Poly(2-ethyl 2-oxazoline) (Peoz)mentioning

confidence: 99%

Polymers for Protein Conjugation

Pasut

2014

Polymers

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Polyethylene glycol (PEG) at the moment is considered the leading polymer for protein conjugation in view of its unique properties, as well as to its low toxicity in humans, qualities which have been confirmed by its extensive use in clinical practice. Other polymers that are safe, biodegradable and custom-designed have, nevertheless, also been investigated as potential candidates for protein conjugation. This review will focus on natural polymers and synthetic linear polymers that have been used for protein delivery and the results associated with their use. Genetic fusion approaches for the preparation of protein-polypeptide conjugates will be also reviewed and compared with the best known chemical conjugation ones.

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Soluble polymeric carriers for drug delivery. Part 2. Preparation and in vivo behaviour of N-acylethylenimine copolymers

Cited by 97 publications

References 14 publications

Well‐defined poly(oxazoline)‐b‐poly(acrylate) amphiphilic copolymers: From synthesis by polymer–polymer coupling to self‐organization in water

Well‐defined poly(oxazoline)‐b‐poly(acrylate) amphiphilic copolymers: From synthesis by polymer–polymer coupling to self‐organization in water

A Systematic Study on the Self-Assembly Behaviour of Multi Component Fmoc-Amino Acid-Poly(oxazoline) Systems

Polymers for Protein Conjugation

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