Soluble Receptor for Advanced Glycation End-Product (sRAGE)/Pentosidine Ratio: A Potential Risk Factor Determinant for Type 2 Diabetic Retinopathy

Ng, Zhi Xiang; Chua, Kek Heng; Iqbal, Tajunisah; Kuppusamy, Umah Rani

doi:10.3390/ijms14047480

Cited by 19 publications

(16 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recent work suggests that sRAGE/pentosidine ratio could be a risk factor determinant for DR (Ng et al, 2013 ). This study recruited 606 subjects (171 NDR, 125 with NPDR, 75 with PDR, and 235 healthy controls).…”

Section: Markers Of Diabetic Retinopathymentioning

confidence: 99%

Molecular Markers of Diabetic Retinopathy: Potential Screening Tool of the Future?

2016

View full text Add to dashboard Cite

Diabetic retinopathy (DR) is among the leading causes of new onset blindness in adults. Effective treatment may delay the onset and progression of this disease provided it is diagnosed early. At present retinopathy can only be diagnosed via formal examination of the eye by a trained specialist, which limits the population that can be effectively screened. An easily accessible, reliable screening biomarker of diabetic retinopathy would be of tremendous benefit in detecting the population in need of further assessment and treatment. This review highlights specific biomarkers that show promise as screening markers to detect early diabetic retinopathy or even to detect patients at increased risk of DR at the time of diagnosis of diabetes. The pathobiology of DR is complex and multifactorial giving rise to a wide array of potential biomarkers. This review provides an overview of these pathways and looks at older markers such as advanced glycation end products (AGEs), inflammatory markers, vascular endothelial growth factor (VEGF) as well as other newer proteins with a role in the pathogenesis of DR including neuroprotective factors such as brain derived neurotrophic factor (BDNF) and Pigment Epithelium Derived Factor (PEDF); SA100A12, pentraxin 3, brain natriuretic peptide, apelin 3, and chemerin as well as various metabolites such as lipoprotein A, folate, and homocysteine. We also consider the possible role of proteins identified through proteomics work whose levels are altered in the sera of patients with DR as screening markers though their role in pathophysiology remains to be characterized. The role of microRNA as a promising new screening marker is also discussed.

show abstract

Section: Markers Of Diabetic Retinopathymentioning

confidence: 99%

Molecular Markers of Diabetic Retinopathy: Potential Screening Tool of the Future?

2016

View full text Add to dashboard Cite

show abstract

“…Soluble RAGE blood levels are low in patients with diabetic complications in comparison with diabetic patients without complications and nondiabetic subjects [ 37 ]. By contrast, increased levels of this receptor in patients with PDR compared with those with NPDR or without DR have also been reported [ 47 , 48 ].…”

Section: Advanced Glycation End Productsmentioning

confidence: 99%

Circulating Biomarkers of Diabetic Retinopathy: An Overview Based on Physiopathology

Simó‐Servat

Simó

Hernández

2016

Journal of Diabetes Research

View full text Add to dashboard Cite

Diabetic retinopathy (DR) is the main cause of working-age adult-onset blindness. The currently available treatments for DR are applicable only at advanced stages of the disease and are associated with significant adverse effects. In early stages of DR the only therapeutic strategy that physicians can offer is a tight control of the risk factors for DR. Therefore, new pharmacological treatments for these early stages of the disease are required. In order to develop therapeutic strategies for early stages of DR new diagnostic tools are urgently needed. In this regard, circulating biomarkers could be useful to detect early disease, to identify those diabetic patients most prone to progressive worsening who ought to be followed up more often and who could obtain the most benefit from these therapies, and to monitor the effectiveness of new drugs for DR before more advanced DR stages have been reached. Research of biomarkers for DR has been mainly based on the pathogenic mechanism involved in the development of DR (i.e., AGEs, oxidative stress, endothelial dysfunction, inflammation, and proangiogenic factors). This review focuses on circulating biomarkers at both early and advanced stages that could be relevant for the prediction or detection of DR.

show abstract

“…There is substantial evidences to support the involvement of oxidative stress in irreversible cellular damage found in diabetes mellitus (Ng, Kuppusamy, Iqbal, & Chua, ; Ng, Chua, Iqbal, & Kuppusamy, ; Ng, Chua, Tajunisah, Pendek, & Kuppusamy, ). Previous studies showed that treatment with dietary antioxidants ameliorates diabetes mellitus and its complications (Montonen, Knekt, Järvinen, & Reunanen, ).…”

Section: Introductionmentioning

confidence: 99%

Effect of in vitro digestion on the total polyphenol and flavonoid, antioxidant activity and carbohydrate hydrolyzing enzymes inhibitory potential of selected functional plant‐based foods

See

2019

J Food Process Preserv

View full text Add to dashboard Cite

This study aimed to investigate the effect of in vitro digestion on the total antioxidant activity and carbohydrate hydrolyzing enzymes inhibitory potential of 12 functional plant‐based foods. Undigested Centella asiatica showed the highest total antioxidant activity, phenolic and flavonoid content while Morus Alba and Dioscorea polystachya displayed the highest α‐glucosidase and α‐amylase inhibitory potential, respectively. In vitro digestion significantly (p < 0.05) increased the radical scavenging and carbohydrate hydrolyzing enzymes inhibitory activities in all plant extracts. Both phenolic (r = 0.840, p < 0.001) and flavonoid (r = 0.549, p < 0.01) contents were positively correlated with the total antioxidant activity. The activity in the aerial part of plants were significantly affected by digestion process when compared to tuber part. Principle component analysis showed that in vitro digestion contributed to 47% of total activity variation. In vitro digestion could induce the reducing power, radical scavenging, and carbohydrate hydrolyzing enzymes inhibitory potential of functional plant‐based foods involving fruit, flower, seed, root, and tuber. Practical applications Functional plant‐based foods with promising therapeutic potential are widely consumed in Southeast Asia countries either as raw ingredient or food additives due to their health‐oriented composition and good environmental sustainability. Comparison of antioxidant activity and carbohydrate hydrolyzing enzymes inhibitory potential of functional plant‐based foods before and after in vitro digestion could reveal the importance of food digestion process in modulating their health benefit. This study shows that in vitro digestion process could produce functional plant‐based food products with high antioxidant and carbohydrate hydrolyzing enzymes inhibitory activity which are potential alternatives to control postprandial hyperglycemia in the early stage of type 2 diabetes with minimal side effect. The data could also serve as a reference for both consumers and food manufacturers who favor the use of functional plants as food ingredient, additives, or flavoring in food processing for health promoting purpose.

show abstract

Soluble Receptor for Advanced Glycation End-Product (sRAGE)/Pentosidine Ratio: A Potential Risk Factor Determinant for Type 2 Diabetic Retinopathy

Cited by 19 publications

References 27 publications

Molecular Markers of Diabetic Retinopathy: Potential Screening Tool of the Future?

Molecular Markers of Diabetic Retinopathy: Potential Screening Tool of the Future?

Circulating Biomarkers of Diabetic Retinopathy: An Overview Based on Physiopathology

Effect of in vitro digestion on the total polyphenol and flavonoid, antioxidant activity and carbohydrate hydrolyzing enzymes inhibitory potential of selected functional plant‐based foods

Contact Info

Product

Resources

About