Soluble silicon patterns and templates: calcium phosphate nanocrystal deposition in collagen type 1

Birdi-Chouhan, G.; Shelton, Richard M.; Bowen, James; Oppenheimer, Pola Goldberg; Page, Samuel J.; Hanna, John V.; Peacock, Anna F. A.; Wright, Adrian J.; Grover, Liam M.

doi:10.1039/c6ra19784a

Cited by 5 publications

(3 citation statements)

References 32 publications

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“…Raman spectroscopy showed suppression of a secondary alcohol vibration, with a reduction in the C–O bond peak, between 0 and 200 ppm collagen samples. This suggests that cobalt ions interact specifically with a hydroxyl group. − Although this is present within the hydroxyproline, previous studies into complex interactions with collagens show preferential binding to terminal sites of the molecule . Therefore, it is more likely that the cobalt ions interact with the hydroxyl structure at the carboxylic terminal.…”

Section: Discussionmentioning

confidence: 99%

“… 52 − 54 Although this is present within the hydroxyproline, previous studies into complex interactions with collagens show preferential binding to terminal sites of the molecule. 55 Therefore, it is more likely that the cobalt ions interact with the hydroxyl structure at the carboxylic terminal. DSC measurements showed that a 14% decrease in energy is required to remove bound water from the 200 ppm CoCol gel.…”

Section: Discussionmentioning

confidence: 99%

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Influence of Cobalt Ions on Collagen Gel Formation and Their Interaction with Osteoblasts

McCarthy¹,

Floyd²,

Addison³

et al. 2018

ACS Omega

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Metals on metal implants have long been used in arthroplasties because of their robustness and low dislocation rate. Several relatively low-corrosion metals have been used in arthroplasty, including 316L stainless steel, titanium, and cobalt–chromium–molybdenum alloy. Debris from these implants, however, has been found to cause inflammatory responses leading to unexpected failure rates approaching 10% 7 years surgery. Safety assessment of these materials traditionally relies on the use of simple two-dimensional assays, where cells are grown on the surface of the material over a relatively short time frame. It is now well-known that the composition and stiffness of the extracellular matrix (ECM) have a critical effect on cell function. In this work, we have evaluated how cobalt ions influence the assembly of type I collagen, the principle component of the ECM in bone. We found that cobalt had a significant effect on collagen matrix formation, and its presence results in local variations in collagen density. This increase in heterogeneity causes an increase in localized mechanical properties but a decrease in the bulk stiffness of the material. Moreover, when collagen matrices contained cobalt ions, there was a significant change in how the cells interacted with the collagen matrix. Fluorescence images and biological assays showed a decrease in cell proliferation and viability with an increase in cobalt concentration. We present evidence that the cobalt ion complex interacts with the hydroxyl group present in the carboxylic terminal of the collagen fibril, preventing crucial stabilizing bonds within collagen formation. This demonstrates that the currently accepted toxicity assays are poor predictors of the longer-term biological performance of a material.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Influence of Cobalt Ions on Collagen Gel Formation and Their Interaction with Osteoblasts

McCarthy¹,

Floyd²,

Addison³

et al. 2018

ACS Omega

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“…In this field, the mechanism of HAP’s deposition in collagen and silicon-related collagen mineralization are the focus. In view of the fact that silicon accounts for 0.5 wt % of newly formed bone and that the lack of silicon will lead to skeletal deformity, scientists have long found the important role of silicon in paleontology or collagen mineralization. Recently, silicon-related collagen mineralization has shown important progress. − For example, silicon-reinforced collagen can be used as a template for more orderly deposition of HAP .…”

Section: Biomineralization Foundation Of Hard Tissuesmentioning

confidence: 99%

Progress on Biomimetic Mineralization and Materials for Hard Tissue Regeneration

Wang

Liu

Guo

et al. 2021

ACS Biomater. Sci. Eng.

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Biomineralization is a process in which natural organisms regulate the crystal growth of inorganic minerals, resulting in hierarchical structured biominerals with excellent properties. Typical biominerals in the human body are the bones and teeth, and damage to these hard tissues directly affect our daily lives. The repair of bones and teeth in a biomimetic way, either by using a biomimetic mineralization strategy or biomimetic materials, is the key for hard tissue regeneration. In this review, we briefly introduce the structure of bone and tooth, and highlight the fundamental role of collagen mineralization in tissue repair. The recent progress on intra-/extrafibrillar collagen mineralization by a biomimetic strategy or materials is presented, and their potential for tissue regeneration is discussed. Then, recent achievements on bone and tooth repair are summarized, and these works are discussed in the view of materials science and biological science, providing a broader vision for the future research of hard tissue repair techniques. Lastly, recent progress on hard tissue regeneration is concluded, and existing problems and future directions are prospected.

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Collagen‐Electrohydrodynamic Hierarchical Lithography for Biomimetic Photonic Micro‐Nanomaterials

McCarthy,

Thomas,

Oppenheimer

et al. 2024

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Biologically engineered nanomaterials give rise to unique and intriguing properties, which are not available in nature. The full‐realization of such has been hindered by the lack of robust and straightforward techniques to produce the required architectures. Here a new bottomup bionano‐engineering route is developed to construct nanomaterials using a guided assembly of collagen building blocks, establishing a lithographic process for three‐dimensional collagen‐based hierarchical micronano‐architectures. By introducing optimized hybrid electro‐hydrodynamic micronano‐lithography exploiting collagen molecules as biological building blocks to self‐assemble into a complex variety of structures, quasi‐ordered mimics of metamaterials‐like are constructed. The tailor‐designed engineered apparatus generates the underlying substrates with vertical orientation of collagen at controlled speeds. Templating these hierarchical structures into inorganic materials allows the replication of their network into periodic metal micronano‐assemblies. These generate substrates with interesting optical properties, suggesting that size‐and‐orientation dependent nanofilaments with varying degree of lateral order yield distinctly coloured structures with characteristic optical spectra correlated with observed colours, which varying diameters and interspacing, are attributable to coherent scattering by different periodicity of each fibrous micronano‐structure. The artificial mimics display similar optical characteristics to the natural butterfly wing's structure, known to exhibit extraordinary electromagnetic properties, driving future applications in cloaking, super‐lenses, photovoltaics and photodetectors.

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Soluble silicon patterns and templates: calcium phosphate nanocrystal deposition in collagen type 1

Abstract: OSA interactsviaionic cross-linking to collagen molecules; free hydroxyl ions recruit CaP nano-precursors and aid nucleation within the fibrils.

Cited by 5 publications

References 32 publications

Influence of Cobalt Ions on Collagen Gel Formation and Their Interaction with Osteoblasts

Influence of Cobalt Ions on Collagen Gel Formation and Their Interaction with Osteoblasts

Progress on Biomimetic Mineralization and Materials for Hard Tissue Regeneration

Collagen‐Electrohydrodynamic Hierarchical Lithography for Biomimetic Photonic Micro‐Nanomaterials

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