Soluble ST2 and GDF15 biomarkers analysis in atrial fibrillation.

Abstract

Objective: Atrial fibrillation (AF) is a common and clinically relevant supra-ventricular arrhythmia which represents an independent risk factor for development of heart failure as well as for ischemic stroke. Clinical management of this pathology can be still challenging in many patients, in particular the older ones and/or those which present comorbidity. The interest in biomarkers for diagnosis and management of the AF becomes more evident in recent years. We studied the possible role of the soluble sST2 and the GDF15 as biomarkers to stratify the risk of patients with persistent or permanent AF. Method: The serum concentrations of these biomarkers have been measured in a group of 58 patients (mean age 83.6 ? 6.0 years) and in a control set of 40 individuals. Results: The mean serum concentration of sST2 is 22.6 (18.85-25.35) ng/mL in the AF group, while