Soluble ST2 in end‐stage heart failure, before and after support with a left ventricular assist device

Tseng, Cheyenne C. S.; Huibers, Manon M. H.; Gaykema, Lonneke H.; Koning, E. Siera-de; Ramjankhan, Faiz; Maisel, Alan S.; Jonge, Nicolaas de

doi:10.1111/eci.12886

Cited by 29 publications

(34 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Tseng et al found that the patients in the endstage of HF had a higher sST2 level compared with the patients in the NYHA stage II and III of HF, but the level could decrease within 3 months after implantation of left ventricular assist device [16]. Shah et al [17] found that sST2 levels were significantly associated with abnormal changes in function and structure such as ventricular enlargement, LV diastolic dysfunction etc. In our study, Spearman correlation analysis results indicated that sST2 could be an independent risk factor for heart failure diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Comparison of predictive value of NT-proBNP, sST2 and MMPs in heart failure patients with different ejection fractions

Pan

Yang

et al. 2020

BMC Cardiovasc Disord

View full text Add to dashboard Cite

Background: This study sought to compare the predictive value of NT-proBNP, sST2 and MMPs in HF with different ejection fractions from a population in southern China. Methods: A cross-sectional study was conducted on 113 HF patients admitted to Fujian Provincial Hospital from December 2016 to March 2018.The patients were divided into three subgroups: 60 cases in HFpEF group (LVEF≥50%), 28 cases in HFmrEF group (41% ≤ LVEF≤49%) and 25 cases in HFrEF group (LVEF≤40%). ELISA method was applied to detect the concentrations of sST2, MMP-2 and MMP-9. Electrochemical luminescence immunoassay was applied to detect the concentration of plasma NT-proBNP. Univariate and multivariate Cox and logistic regression models were used to analyze the diagnostic significance of these plasma biomarkers in HF patients. Kaplan-Meier survival curves were used to assess the prognostic value of sST2 in the incidence of long-term adverse events during study. Results: This study showed that plasma sST2 levels in HFrEF or HFmrEF patients were significantly higher than in HFpEF patients. Plasma levels of MMP-2 and MMP-9 in HFrEF patients were apparently higher than in HFpEF or HFmrEF patients. For the diagnosis of HFpEF, the AUC of NT-proBNP was higher than that of sST2, MMP-2 and MMP-9, which were 0.881, 0.717, 0.705 and 0.597, respectively. For the diagnosis of HFmrEF, the AUC of plasma sST2 was higher than that of MMP-2, MMP-9 and NT-proBNP, which were 0.799, 0.678, 0.676 and 0.793, respectively. For the diagnosis of HFrEF, the AUC of plasma NT-proBNP, sST2, MMP-2, and MMP-9 were 0.945, 0.820, 0.814, and 0.774 respectively. Spearman correlation analysis showed that plasma sST2 levels were significantly correlated with plasma MMP-2, MMP-9 and NT-proBNP levels. Further logistic regression analysis showed that except MMP-9, the biomarkers sST2 (OR = 1.960), MMP-2 (OR = 0.805) and NT-proBNP (OR = 0.002) were all independent risk factors for patients with heart failure. Survival analysis results suggested that for patients with HFmrEF, a higher level of plasma sST2 (≥ 0.332 ng/ml at admission) may predict a higher risk of endpoint events and a lower survival rate (P < 0.025).

show abstract

Section: Discussionmentioning

confidence: 99%

Comparison of predictive value of NT-proBNP, sST2 and MMPs in heart failure patients with different ejection fractions

Pan

Yang

et al. 2020

BMC Cardiovasc Disord

View full text Add to dashboard Cite

show abstract

“…The sST2 levels were positively correlated with the degree of cardiac fibrosis ( 150 ). Along these lines, it has been recently observed that left ventricular assist device (LVAD) resulted in a significant drop in sST2 levels with normalization within 3 months post-implantation, thus lessened heart fibrosis and inflammation ( 151 ).…”

Section: Il-33/st2 Axis In Heart Fibrosismentioning

confidence: 99%

IL-33/ST2 Axis in Organ Fibrosis

2018

View full text Add to dashboard Cite

Interleukin 33 (IL-33) is highly expressed in barrier sites, acting via the suppression of tumorigenicity 2 receptor (ST2). IL-33/ST2 axis has long been known to play a pivotal role in immunity and cell homeostasis by promoting wound healing and tissue repair. However, it is also involved in the loss of balance between extensive inflammation and tissue regeneration lead to remodeling, the hallmark of fibrosis. The aim of the current review is to critically evaluate the available evidence regarding the role of the IL-33/ST2 axis in organ fibrosis. The role of the axis in tissue remodeling is better understood considering its crucial role reported in organ development and regeneration. Generally, the IL-33/ST2 signaling pathway has mainly anti-inflammatory/anti-proliferative effects; however, chronic tissue injury is responsible for pro-fibrogenetic responses. Regarding pulmonary fibrosis mature IL-33 enhances pro-fibrogenic type 2 cytokine production in an ST2- and macrophage-dependent manner, while full-length IL-33 is also implicated in the pulmonary fibrotic process in an ST2-independent, Th2-independent fashion. In liver fibrosis, evidence indicate that when acute and massive liver damage occurs, the release of IL-33 might act as an activator of tissue-protective mechanisms, while in cases of chronic injury IL-33 plays the role of a hepatic fibrotic factor. IL-33 signaling has also been involved in the pathogenesis of acute and chronic pancreatitis. Moreover, IL-33 could be used as an early marker for ulcer-associated activated fibroblasts and myofibroblast trans-differentiation; thus one cannot rule out its potential role in inflammatory bowel disease-associated fibrosis. Similarly, the upregulation of the IL-33/ST2 axismay contribute to tubular cell injury and fibrosis via epithelial to mesenchymal transition (EMT) of various cell types in the kidneys. Of note, IL-33 exerts a cardioprotective role via ST2 signaling, while soluble ST2 has been demonstrated as a marker of myocardial fibrosis. Finally, IL-33 is a crucial cytokine in skin pathology responsible for abnormal fibroblast proliferation, leukocyte infiltration and morphologic differentiation of human endothelial cells. Overall, emerging data support a novel contribution of the IL-33/ST2 pathway in tissue fibrosis and highlight the significant role of the Th2 pattern of immune response in the pathophysiology of organ fibrosis.

show abstract

“…Thus a relationship exists between sST2 and cardiac dysfunction [41,66]. A recent study showed that sST2 plasma levels normalized within 3 months post-implantation of a left ventricular assist device (LVAD) in endstage HF patients [67]; this indicates that unloading the heart by LVAD placement lessens fibrosis. Because these are end-stage HF patients, many of whom will have multi-organ involvement, this finding may not be limited to the heart.…”

Section: Fibrosis Marker Sst2mentioning

confidence: 99%