Soluble thrombomodulin ameliorates aberrant hemostasis after rewarming in a rat accidental hypothermia model

Bioprotective Role of Platelet-Derived Microvesicles in Hypothermia: Insight into the Differential Characteristics of Peripheral and Splenic Platelets

“…A limitation of this study is that we focused on skeletal muscle as a tissue damaged by hypothermia. We previously reported that Wnt/β-catenin signaling also plays an important role in the regeneration of epidermal tissue in frostbite skin [56,57]. Therefore, we speculate that PDMVs enhance Wnt/β-catenin signaling via the activation of splenic platelets, which may also be relevant to the recovery of frostbitten skin and other injured tissues.…”