Soluble Toll-like receptor 4 is a potential serum biomarker in non-small cell lung cancer

Wei, Feng; Yang, Fan; Li, Jing; Zheng, Yu; Yu, Wenwen; Yang, Lili; Ren, Xiubao

doi:10.18632/oncotarget.9496

Cited by 34 publications

(30 citation statements)

References 30 publications

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“…HMGB1 has been associated with the prognosis of patients with lung. The expression levels of HMGB1 in the tissue and serum of patients with lung cancer are significantly higher compared those of normal lung tissue samples (62,63). HMGB1 levels are positively associated with tumor size, tumor node metastasis stage and distant metastasis (42).…”

Section: Role Of Hmgb1 In Lung Cancermentioning

confidence: 95%

The function and mechanism of HMGB1 in lung cancer and its potential therapeutic implications (Review)

Yang

2018

Oncol Lett

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As a non-histone chromatin-associated protein, high-mobility group box-1 (HMGB1) performs a pivotal function in various human diseases, including autoimmune diseases, neurodegenerative diseases and cancer. Overexpression of HMGB1 has been demonstrated in numerous types of cancer, including breast cancer, colorectal cancer, lung cancer and hepatocellular carcinoma. However, the underlying mechanism of HMGB1 function in lung cancer remains to be elucidated. The present study aimed to analyze, and summarize the role and mechanism of HMGB1 in lung cancer by retrieving available literature regarding HMGB1 in association with lung cancer. It provides comprehensive information on the association of HMGB1 with the carcinogenesis and progression of lung cancer, and discusses the molecular mechanism of these processes. HMGB1 may induce tumorigenesis, metastasis and chemotherapy resistance in lung cancer. Overall, it is evident that HMGB1 serves an important role in the development and progression of lung cancer, and this review warrants further investigation into HMGB1 as a novel target for cancer therapy.

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Section: Role Of Hmgb1 In Lung Cancermentioning

confidence: 95%

The function and mechanism of HMGB1 in lung cancer and its potential therapeutic implications (Review)

Yang

2018

Oncol Lett

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“…Furthermore, high expression of TLR4 in human hepatocellular carcinoma (HCC) tissues has also been found associated with poor survivals in patients [ 103 ]. On the contrary, our previous study has shown that low levels of serum soluble TLR4 were associated with poor survival of early stage NSCLC patients [ 104 ]. Meanwhile, serum TLR4 levels of patients with distant metastasis was much lower than that of patients without metastasis [ 104 ].…”

Section: Introductionmentioning

confidence: 90%

The role of toll-like receptor 4 in tumor microenvironment

Yang

Wei

et al. 2017

Oncotarget

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Tumors are closely related to chronic inflammation, during which there are various changes in inflammatory sites, such as immune cells infiltration, pro-inflammation cytokines production, and interaction between immune cells and tissue cells. Besides, substances, released from both tissue cells attacked by exogenous etiologies, also act on local cells. These changes induce a dynamic and complex microenvironment favorable for tumor growth, invasion, and metastasis. The toll-like receptor 4 (TLR4) is the first identified member of the toll-like receptor family that can recognize pathogen-associated molecular patterns (PAMPs) and damage-associated molecular pattern (DAMPs). TLR4 expresses not only on immune cells but also on tumor cells. Accumulating evidences demonstrated that the activation of TLR4 in tumor microenvironment can not only boost the anti-tumor immunity but also give rise to immune surveillance and tumor progression. This review will summarize the expression and function of TLR4 on dendritic cells (DCs), tumor-associated macrophages (TAMs), T cells, myeloid-derived suppressor cells (MDSCs), tumor cells as well as stromal cells in tumor microenvironment. Validation of the multiple role of TLR4 in tumors could primarily pave the road for the development of anti-tumor immunotherapy.

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“…Reduced serum TLR9 concentrations have been detected in patients with breast cancer; indeed, low TLR9 levels were associated with disease progression and advanced stages . A recent study found that serum TLR4 was increased in non‐small‐cell lung carcinoma, but the cellular origin was not studied . To our knowledge, no previous studies have investigated serum TLR concentrations in CRC.…”

mentioning

confidence: 94%

Serum TLR2 and TLR4 levels in colorectal cancer and their association with systemic inflammatory markers, tumor characteristics, and disease outcome

Paarnio

Tuomisto

Väyrynen

et al. 2019

APMIS

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Paarnio K, Tuomisto A, V€ ayrynen SA, V€ ayrynen JP, Klintrup K, Ohtonen P, M€ akinen MJ, M€ akel€ a J, Karttunen TJ. Serum TLR2 and TLR4 levels in colorectal cancer and their association with systemic inflammatory markers, tumor characteristics, and disease outcome. APMIS 2019; 127: 561-569.Toll-like receptors (TLRs) are involved in colorectal cancer (CRC) pathogenesis. However, the significance of serum TLR concentrations in CRC is unknown. We analyzed serum TLR2 and TLR4 concentrations with ELISA in preoperative samples from 118 patients with CRC and 88 matched controls. We also assessed tissue TLR expression with immunohistochemistry and by detecting serum determinants of systemic inflammation. Most participants (>70%) had undetectable serum TLR2. The mean serum TLR4 levels were lower in patients than in controls (1.1 vs 1.8 ng/mL; p = 0.015). Undetectable TLR4 was more common in stage I (39%) than in stages II-IV (11%, p < 0.001). TLR2 or TLR4 expression in tumor cells did not correlate with serum levels, but abundant TLR2 expression in normal colon epithelium was associated with detectable serum TLR2 (p = 0.034). Undetectable serum TLR2 was linked to high modified Glasgow prognostic scores (p = 0.010), high CRP levels (p = 0.013), blood vessel invasion (p = 0.013), and tended to be associated with worse 5-year survival (p = 0.052). In conclusion, serum TLR2 levels were inversely associated with systemic inflammation in patients with CRC. Moreover, serum TLR2 levels might depend more on normal colorectal mucosa contributions than on tumor tissue contributions. Further studies are required to assess the prognostic value of serum TLR2.

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Soluble Toll-like receptor 4 is a potential serum biomarker in non-small cell lung cancer

Cited by 34 publications

References 30 publications

The function and mechanism of HMGB1 in lung cancer and its potential therapeutic implications (Review)

The function and mechanism of HMGB1 in lung cancer and its potential therapeutic implications (Review)

The role of toll-like receptor 4 in tumor microenvironment

Serum TLR2 and TLR4 levels in colorectal cancer and their association with systemic inflammatory markers, tumor characteristics, and disease outcome

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