Solute and water flows in thin limbs of Henle's loop in the hamster kidney

Dj, Marsh

doi:10.1152/ajplegacy.1970.218.3.824

Cited by 98 publications

(49 citation statements)

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“…At the papillary tip, DLH urea concentration is less than that in CC and it far exceeds the corresponding value in the scheme of Kokko and Rector (1972). These predictions are in agreement with Pennell et al (1975) and Marsh (1970).…”

Section: Loop Of Henlesupporting

confidence: 79%

“…Concerning the behaviour of salt in the loop of Henle the results of this model support the assumptions of Kokko and Rector (1972): At the papilla the computed salt concentration in the DLH fluid exceeds that in the adjacent tALH and CC (Marsh, 1970;Johnston et al, 1977) and salt leaves tALH in a strictly passive mode (Imai and Kokko, 1974).…”

Section: Loop Of Henlesupporting

confidence: 67%

“…Indeed, as fluid flows up the first portion of the tALH, the model predicts a rise in urea concentration due to urea entry. This feature was observed in vivo by Marsh (1970). However, in other parts of the tALH urea concentration in the composite tALH is almost in equilibrium with the urea concentration in CC, and both urea entry and exit occur depending on the relative location in the medulla.…”

Section: Loop Of Henlementioning

confidence: 67%

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Renal countercurrent system: Role of collecting duct convergence and pelvic urea predicted from a mathematical model

1983

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Abstract.A differential equation model of the renal countercurrent system has been developed and physiological data from nephron segments were incorporated together with recently suggested urea recycling from renal pelvis to inner medulla and, particularly, an exponential reduction in the number of collecting tubules towards the renal papilla. The role of these features for the countercurrent concentrating mechanism has been studied by simulation runs. The computations, using the multiple shooting method, provide predictions about concentration profiles for salt and urea in tubes (nephron segments) and in the central core along the entire medullary countercurrent system. The results indicate that this model, without active salt or urea transport in the inner medulla, yields concentration gradients along the medullary axis compatible with those measured in the tissue.

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Section: Loop Of Henlesupporting

confidence: 79%

Section: Loop Of Henlesupporting

confidence: 67%

Section: Loop Of Henlementioning

confidence: 67%

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Renal countercurrent system: Role of collecting duct convergence and pelvic urea predicted from a mathematical model

1983

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“…Reports in the literature describe water-and solute-permeable descending limbs in hamsters (8,19), rats (1,3,9), chinchillas (1,2,6), and rabbits (10,13,21). The descending limb of Henle's loop has been found in all species to be water permeable and moderately permeable to NaCl and urea.…”

mentioning

confidence: 99%

Immunomorphometric study of rat renal inner medulla

Mejia

Wade

2002

American Journal of Physiology-Renal Physiology

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We utilized immunofluorescent immunolabeling of renal tissue sections to identify and count tubules at specified depths of the rat renal inner medulla. We used primary antibodies to aquaporin-1 (AQP1; labeling thin descending limbs), aquaporin-2 (AQP2; labeling inner medullary collecting ducts), the rat kidney-specific chloride channel (ClC-K1; labeling thin ascending limbs), and von Willebrand factor (labeling descending vasa recta). Secondary antibodies conjugated to different fluorophores were used, giving up to a three-color display. Labeled structures were then identified and counted. At each level sampled in the inner medulla, many more thin limbs were labeled by ClC-K1 than AQP1. In addition, thin limbs were found to label with antibodies to ClC-K1 on both sides of their hairpin turns. We conclude that the descending thin limbs shift from expressing AQP1 to expressing ClC-K1 some distance before the point where they turn and begin to ascend. Mathematical models can use our quantitative data to explore implications for the urine-concentrating mechanism.

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“…In addition, characteristics of solute and water transport across the thin descending and ascending limb of Henle's loop do not fit well with the active NaCI transport model (Gottschalk et al 1963 ;Jamison 1968 ; Morgan and Berliner 1968 ;Marsh 1970 ; Kokko 1970Kokko , 1972Pennel et al 1974 ; Imai andKokko 1974, 1976 ;Elalouf et al 1985Elalouf et al , 1986a. Stephenson (1972) and Kokko and Rector (1972) independently proposed models which incorporated passive movement of NaCl and urea into a "single effect" operating in thin ascending limb of Henle's loop (TAL).…”

mentioning

confidence: 99%

Simulation of the Profile of Water, NaCl, and Urea Transport in the Countercurrent Multiplication System between Thin Ascending Limb and Inner Medullary Collecting Duct.

Hamada

Imai

Aoki

et al. 1992

Tohoku J. Exp. Med.

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We simulated the profiles of water, NaCI, and urea transport in the countercurrent multiplication system between thin ascending limb (TAL) and inner medullary collecting duct (IMCD) by a mathematical model consisting of three compartments (TAL, IMCD, and CNW [capillary network] ), using phenomenological coefficients for hamsters. They are separated by two membranes with distinct permeability properties. The primary driving force which generates "single effect" has a lower reflection coefficient for urea than for NaCI in IMCD. The difference in urea and NaCI concentrations between CNW and IMCD provides an effective osmotic driving force which is favorable for water absorption from IMCD without physicochemical osmotic gradient. The entry of water in the CNW reduces the concentration in CNW and generates the concentration gradients which are favorable for these solutes to diffuse out of TAL. Thus, the fluid in IMCD is concentrated and that in TAL is diluted. The results of simulation showed that the concentration gradients were generated along the medullary axis, resulting in excretion of hypertonic urine. In addition, we examined effects of changes in phenomenological coefficients of IMCD on this concentrating system. Decreases in permeability and in reflection coefficient for urea and increase in hydraulic conductivity increased the osmotic gradients along each compartment.urine concentration mechanism ; countercurrent multiplication system ; inner medullary collecting duct ; thin ascending limb The countercurrent system in the renal medulla is essential for the generation of an osmotic gradient along the renal medulla (Jamison and Ktiz 1982).

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Solute and water flows in thin limbs of Henle's loop in the hamster kidney

Cited by 98 publications

References 0 publications

Renal countercurrent system: Role of collecting duct convergence and pelvic urea predicted from a mathematical model

Renal countercurrent system: Role of collecting duct convergence and pelvic urea predicted from a mathematical model

Immunomorphometric study of rat renal inner medulla

Simulation of the Profile of Water, NaCl, and Urea Transport in the Countercurrent Multiplication System between Thin Ascending Limb and Inner Medullary Collecting Duct.

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