Solution and biological behaviour of enrofloxacin metalloantibiotics: A route to counteract bacterial resistance?

Adsorption of enrofloxacin in presence of Zn(II) on a calcareous soil

“…2) fitted adsorption Scheme 1. Molecular structure of ENR (1-cyclopropyl-7-(4-ethyl-1-piperazinyl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolonecarboxylic acid) and its ionization constants (Saraiva et al, 2010). kinetic data better than the pseudo-first order model (data not shown). The rate constant k 2 and the maximum adsorbed amount per mass unit of adsorbent Q max,model (model parameters) were determined and the calculated Q max,model values were very close to the experimental ones Q max,exp (Table 1).…”

“…Thus, these results tended to confirm the observations drawn from kinetic and variable pH experiments concerning the probable interaction of ENR and Zn(II) at the soil surface, which would lead to a lower ENR mobility in soils. However, the presence of zinc showed smaller influence on ENR retention compared to copper (Graouer-Bacart et al, 2013) probably because Cu(II) has stronger sorption affinity for soil particles than Zn(II) (Flogeac et al, 2007;Jalali and Moharrami, 2007;Lafuente et al, 2008;Usman, 2008) and forms more stable complexes with ENR (Saraiva et al, 2010).…”

“…Therefore, the simultaneous presence of ENR and metal cations in soils is very likely. The ability of ENR to form complexes with metal cations is well known (Efthimiadou et al, 2008;Saraiva et al, 2010;Tarushi et al, 2010;Ftouni et al, 2012). Thus metal cations are expected to influence its environmental fate.…”

“…Laboratory studies were conducted to characterize ENR adsorption behavior and its interaction with zinc at the water/soil interface. ENR structure contains functional groups able to form coordination complexes with zinc in aqueous medium and the corresponding stability constants were previously determined (Saraiva et al, 2010). Also, Zn(II)-ENR solid complexes were synthesized and characterized (Efthimiadou et al, 2008;Tarushi et al, 2010).…”

The antibacterial activity and toxicity of enrofloxacin are decreased by nanocellulose conjugated with aminobenzyl purin

“…Importantly, its long exposure leads to bacterial resistance and toxic effects on liver and kidney [4]. Based on previous studies, the antibiotic is strongly adsorbed by clay minerals and natural zeolites [5].…”