Solution- and solid-phase synthesis and anti-HIV activity of maslinic acid derivatives containing amino acids and peptides

Parra, Andrés; Rivas, Francisco; López, Pilar; Garcı́a-Granados, Andrés; Martı́nez, Antonio; Alberício, Fernando; Márquez, Nieves; Muñóz, Eduardo

doi:10.1016/j.bmc.2008.12.041

Cited by 66 publications

(47 citation statements)

References 62 publications

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“…There are two patented products extracted from 2POMSW: oleanoic acid and maslinic acid. Maslinic acid is being used for a treatment against the human immunodeficiency virus (HIV-1) (Parra et al, 2009). The walls of the olives are rich in polysaccharides such as L-arabinose.…”

Section: Two-phase Olive Mill Solid Wastes (2pomsw)mentioning

confidence: 99%

Olive Oil Mill Waste Treatment:Improving the Sustainability of the Olive Oil Industry with Anaerobic Digestion Technology

Rincón¹,

Fermoso²,

Borja³

2012

Olive Oil - Constituents, Quality, Health Properties and Bioconversions

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Section: Two-phase Olive Mill Solid Wastes (2pomsw)mentioning

confidence: 99%

Olive Oil Mill Waste Treatment:Improving the Sustainability of the Olive Oil Industry with Anaerobic Digestion Technology

Rincón¹,

Fermoso²,

Borja³

2012

Olive Oil - Constituents, Quality, Health Properties and Bioconversions

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“…1,2 MA (2a,3b-2,3-dihydroxy-olean-12-en-28-oic acid), which is abundant in olive fruit skin, has attracted much attention due to its anti-tumor, 3 anti-HIV, 4 anti-oxidation 5 and hypoglycemic [6][7][8] activities. However, important questions whether MA can prevent oxidative stress to consequently alleviate or ameliorate microvascular and macrovascular complications in diabetes remain unanswered.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant effects of maslinic acid in livers, hearts and kidneys of streptozotocin-induced diabetic rats: effects on kidney function

et al. 2013

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Studies indicate that hyperglycemia-induced oxidative stress triggers the development of microvascular and macrovascular complications in diabetes. Accordingly, we hypothesized that maslinic acid (MA) prevents these complications due to its antioxidant properties. We, therefore, investigated the effects of 5-week MA treatment of streptozotocin (STZ)-induced diabetic rats on anti-oxidative status of cardiac, hepatic and renal tissues as well as on kidney function. Proximal tubular effects of MA were studied in anesthetized rats challenged with hypotonic saline after a 3.5 h equilibration for 4 h of 1 h control, 1.5 h treatment and 1.5 h recovery periods using lithium clearance. MA was added to the infusate during the treatment period. Oral glucose tolerance responses to MA were monitored in rats given a glucose load after an 18 h fast. Compared with untreated diabetic rats, MA-treated diabetic animals exhibited significantly low malondialdehyde (MDA, a marker of lipid peroxidation) and increased the activity of antioxidant enzymes; superoxide dismutase and glutathione peroxidase in hepatic, cardiac and renal tissues. The expressions of gastrocnemius muscle GLUT4 and kidney GLUT1 and GLUT2 were assessed to elucidate the mechanism of the hypoglycemic effects of MA. MA-treatment diminished the expression of GLUT1 and GLUT2 in diabetic kidney and reduced glycemia values of diabetic rats. MA administration increased urinary Na þ outputs and additionally the FE Na indicating that at least part of the overall reduction in Na þ reabsorption occurred in the proximal tubules. These results suggest antioxidant effects of MA can ameliorate oxidative stress and improve kidney function in diabetes mellitus.

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“…Maslinic acid is a natural triterpene from Olea europaea L. (1), which acts as an antitumor, antibacterial (2) and anti-HIV substance (3), and exhibits antiallodynic and analgesic properties by regulating cell metabolism and immune function (4). Maslinic acid has been revealed to exert therapeutic effects on a variety of solid tumors, including in bladder, prostate, colon, esophageal, colorectal, cervical and ovarian cancer (5)(6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

Maslinic acid suppresses the growth of human gastric cells by inducing apoptosis via inhibition of the interleukin-6 mediated Janus kinase/signal transducer and activator of transcription 3 signaling pathway

Wang¹,

Tang²,

Zhang³

2017

Oncology Letters

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Abstract. The present study aimed to determine whether maslinic acid effectively inhibits the proliferation of MKN28 cells, and to investigate the mechanisms underlying its antitumor functions. MKN28 cell viability was evaluated using a Cell Counting Kit-8, cell proliferation was analyzed by a colony formation assay and flow cytometry was used to investigate the rate of apoptosis. Western blot analysis was performed in order to determine the differential expression levels of Janus kinase (JAK), signal transducer and activator of transcription 3 (STAT3) and apoptosis associated proteins B-cell lymphoma 2 (Bcl-2), Bcl-2 associated X protein (Bax) and Bcl-2 associated agonist of cell death (Bad). Interleukin-6 (IL-6) concentration was evaluated using ELISA. IL-6 and anti-IL-6 antibodies were used to investigate the role of IL-6 in MKN28 cells treated with maslinic acid proliferation, and the STAT3 phosphorylation rates. The results demonstrated that maslinic acid treatment significantly reduced cell proliferation, induced apoptosis and was accompanied by a significant decrease in Bcl-2, Bax and Bad expression levels. Maslinic acid treatment also resulted in the downregulation of phosphorylated-STAT3 and JAK2, and significantly inhibited the protein expression of IL-6. Maslinic acid is able to inhibit MKN28 cell proliferation and the phosphorylation of STAT3 by downregulating the expression of IL-6. These results suggest that maslinic acid suppresses the growth of MKN28 cells by inducing apoptosis via its inhibition of the IL-6/JAK/STAT3 signaling cascade.

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Solution- and solid-phase synthesis and anti-HIV activity of maslinic acid derivatives containing amino acids and peptides

Cited by 66 publications

References 62 publications

Olive Oil Mill Waste Treatment:Improving the Sustainability of the Olive Oil Industry with Anaerobic Digestion Technology

Olive Oil Mill Waste Treatment:Improving the Sustainability of the Olive Oil Industry with Anaerobic Digestion Technology

Antioxidant effects of maslinic acid in livers, hearts and kidneys of streptozotocin-induced diabetic rats: effects on kidney function

Maslinic acid suppresses the growth of human gastric cells by inducing apoptosis via inhibition of the interleukin-6 mediated Janus kinase/signal transducer and activator of transcription 3 signaling pathway

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