“…The spectrum of efavirenz presents a set of well-resolved resonances, with multiple signals observed for its carbons with the exception of C 2 . Signal multiplicity for EFV carbons was previously reported by Rodrigues de Sousa et al, having been attributed to the presence of more than one polymorphs of efavirenz and to different molecular conformations [26]. The host, γ-CD, exhibits multiple sharp resonances for each type of carbon atom, which is ascribed, for C 1 and C 4 carbons, to differences in the conformation about the α-1,4 bonds, and, for carbons located closer to the rims, as is the case of C 6 , to ambient changes in the hydrogen-bonding network and the varying number of hydration water molecules [27,28].…”