2016
DOI: 10.1016/j.xphs.2015.10.006
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Solution and Solid State Nuclear Magnetic Resonance Spectroscopic Characterization of Efavirenz

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Cited by 9 publications
(7 citation statements)
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“…The spectrum of efavirenz presents a set of well-resolved resonances, with multiple signals observed for its carbons with the exception of C 2 . Signal multiplicity for EFV carbons was previously reported by Rodrigues de Sousa et al, having been attributed to the presence of more than one polymorphs of efavirenz and to different molecular conformations [26]. The host, γ-CD, exhibits multiple sharp resonances for each type of carbon atom, which is ascribed, for C 1 and C 4 carbons, to differences in the conformation about the α-1,4 bonds, and, for carbons located closer to the rims, as is the case of C 6 , to ambient changes in the hydrogen-bonding network and the varying number of hydration water molecules [27,28].…”
Section: C{ 1 H} Cp-mas Nmrsupporting
confidence: 55%
See 1 more Smart Citation
“…The spectrum of efavirenz presents a set of well-resolved resonances, with multiple signals observed for its carbons with the exception of C 2 . Signal multiplicity for EFV carbons was previously reported by Rodrigues de Sousa et al, having been attributed to the presence of more than one polymorphs of efavirenz and to different molecular conformations [26]. The host, γ-CD, exhibits multiple sharp resonances for each type of carbon atom, which is ascribed, for C 1 and C 4 carbons, to differences in the conformation about the α-1,4 bonds, and, for carbons located closer to the rims, as is the case of C 6 , to ambient changes in the hydrogen-bonding network and the varying number of hydration water molecules [27,28].…”
Section: C{ 1 H} Cp-mas Nmrsupporting
confidence: 55%
“…13 C{ 1 H} CP-MAS NMR spectra of (a) EFV, (b) γ-CD, (c) (γ-CD) 3 •(EFV) 2 , and (d) γ-CD•EFV (see labelling in Figure1). Efavirenz carbons were assigned as in Rodrigues de Sousa et al[26].…”
mentioning
confidence: 99%
“…The implementation of several pulse sequences, such as TOSS (Total Suppression of Sidebands) that suppresses sideband signals [7], the dipolar dephasing technique (DD) for signaling non-proton carbons [8], and two-dimensional experiments such as PASS-adjusted spinning sidebands [9], allowed solid state NMR to be applied more broadly. The Figure 1 (EFZ), an antiretroviral drug [14]. In this study, the authors could be found, by solid-state NMR, the difference between EFZ used in the medicine formulations and the polymorphic form obtained by EFZ crystallization in heptane solvent.…”
mentioning
confidence: 71%
“…It should be noted that the position and assignment of signals for solid-state and liquid-state NMR can change, especially for peaks which are very close to one other. 66 , 67 Therefore, the uncritical cloning of the liquid-state assignments to the solid-state spectra should not be attempted at all. In our case, we decided to apply theoretical calculations and compare them with the experimental data.…”
Section: Resultsmentioning
confidence: 99%