Solution conformations of novel redox-active cyclophane based on biindolizinequinoxaline

Баландина, А. А.; Мамедов, В. А.; Latypov, Shamil K.

doi:10.1016/j.molstruc.2008.01.032

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A New Flow Methodology for the Expedient Synthesis of Drug‐Like 3‐Aminoindolizines

Bogdan

James

2012

Adv Synth Catal

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A flow-based synthesis of diversely functionalized indolizines and their aza-analogues is described. These drug-like heterocycles were generated via a tandem Sonogashira/cycloisomerization sequence, starting from widely available 2-bromopyridines and alkynes, employing a simple catalyst system together with 1,8-diazabicycloA C H T U N G T R E N N U N G [5.4.0]undec-7-ene (DBU) as base. The use of flow technology allows a straightforward and rapid access to a variety of novel compounds, and enables linear scale-up from milligram-to gram-scales without a decrease in yield.

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