Solution Coordination Chemistry of Organotin(IV) Cations with Bio-relevant Ligands

El‐Sherif, Ahmed A.

doi:10.1007/s10953-012-9854-z

Cited by 15 publications

(3 citation statements)

References 105 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The spectrofluorimetric and potentiometric titrations (see the distribution diagram in Figure 2) indicate the formation of both (Bu 3 Sn) 4 TPPS and [(Bu 3 Sn) 4 TPPS(OH) 4 ] 4− ; the latter is the species with the highest percentage formed (∼75%) under physiological conditions. 60,61 The stability constants of the M 4 L(OH) i (i = 0 or 4) species indicate that they are not strong complexes; however, TPPS 4− is able to avoid the hydrolysis of the alkyltin cations over the entire pH range investigated, a fact that is observable with a low percentage of M(OH) 2 formation. Due to the high number of degrees of freedom in the system and the large number of data points collected, the low values of the statistical parameters for the titrations can be considered significant at a 95% confidence interval.…”

Section: ■ Discussionmentioning

confidence: 99%

Supramolecular Assemblies Based on Complexes of Nonionic Amphiphilic Cyclodextrins and a meso-Tetra(4-sulfonatophenyl)porphine Tributyltin(IV) Derivative: Potential Nanotherapeutics against Melanoma

et al. 2013

View full text Add to dashboard Cite

Amphiphilic cyclodextrin (ACyD) provides water-soluble and adaptable nanovectors by modulating the balance between the hydrophobic and hydrophilic chains at both CyD sides. This work aimed to design nanoassemblies based on nonionic and hydrophilic ACyD (SC6OH) for the delivery of a poor-water-soluble organotin(IV)-porphyrin derivative [(Bu3Sn)4TPPS] to melanoma cancer cells. To characterize the porphyrin derivatives under simulated physiological conditions, a speciation was performed using complementary techniques. In aqueous solution (≤ 20 μM), (Bu3Sn)4TPPS primarily exists as a monomer (2 in Figure 1), as suggested by the low static anisotropy (ρ ≈ 0.02) with a negligible formation of porphyrin supramolecular aggregates. MALDI-TOF spectra indicate the presence of moieties (i.e., [(Bu3Sn)3TPPS](-)) that are derivatives of the monomeric species. Spectrofluorimetry coupled with potentiometric measurements primarily assesses the presence of the hydrolytic [(Bu3Sn)4TPPS (OH)4](4-) species under physiological conditions. Nanoassemblies of (Bu3Sn)4TPPS/SC6OH were prepared by dispersion of organic films in PBS at pH 7.4 and were investigated using a combination of spectroscopic and morphological techniques. The UV-vis and emission fluorescence spectra of the (Bu3Sn)4TPPS/SC6OH reveal shifts in the peculiar bands of the organotin(IV)-porphyrin derivative due to its interaction with the ACyD supramolecular assemblies in aqueous solution. The mean size was within the range of 100-120 nm. The ξ-potential was negative (-16 mV) for the (Bu3Sn)4TPPS/SC6OH nanoassemblies, with an entrapment efficiency of approximately 67%. The intracellular delivery, cytotoxicity, nuclear morphology and cell growth kinetics were evaluated via fluorescence microscopy on A375 human melanoma cells. The delivery of (Bu3Sn)4TPPS by ACyD with respect to free (Bu3Sn)4TPPS increases the internalization efficiency and cytotoxicity to induce apoptotic cell death and, at lower concentrations, changes the cellular morphology and prevents cell proliferation.

show abstract

Section: ■ Discussionmentioning

confidence: 99%

Supramolecular Assemblies Based on Complexes of Nonionic Amphiphilic Cyclodextrins and a meso-Tetra(4-sulfonatophenyl)porphine Tributyltin(IV) Derivative: Potential Nanotherapeutics against Melanoma

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Moreover, copper is an important biometal which is essential for normal human metabolism and its imbalance leads to deficiency or excess diseases. Cu (II) complexes are preferred candidates for various pharmacological studies due to the presence of its biorelevent ligands (El-Sherif, 2012). These complexes have multiple roles in medicinal proceedings such as antimicrobial, antiviral, anti-inflammatory, antitumor agents, enzyme inhibitors, or chemical nucleases with reduced side effects and it has distinct superoxide-dismutase-(SOD-) mimetic activity (Tisato et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Biochemical study on the potential therapeutic use of novel curcumin copper oxide nanocomposite in diabetic complications in rats

AlSenosy

Prince

Zaher

2018

Benha Veterinary Medical Journal

View full text Add to dashboard Cite

The aim of this study was to investigate the hypoglycemic and antioxidant effect of Curcumin Copper Oxide nano-composite in STZ-induced diabetic rats. Sixty male rats were divided into four equal groups. Group 1 (control) comprised 15 rats received no drugs, Group 2 (Diabetic nontreated group) included 15 rats received no drugs, serve as STZ induced diabetic group. Group 3 (Diabetic nano-curcumin treated group) consists of 15 rats, received curcumin nanoparticle orally at a dose level of 2 mg/kg b.wt/day. Group 4 (Diabetic Curcumin Copper Oxide Nano-Composite treated group): included 15 rats, received curcumin Copper Oxide Nano-Composite at a dose level of 7 mg/kg b.wt/day orally. The obtained results revealed that, diabetic rats showed significant increase in serum glucose and Malondialehyde (MDA) concentrations. However, serum Superoxide dismutase (SOD) activity, Reduced Glutathione (GSH) and insulin concentration in pancreatic tissue were markedly decreased. Moreover, a significant down regulation in Insulin Receptor-A (IRA) and Insulin Receptors Substrate-2 (IRs-2) mRNA gene levels in hepatic tissue were observed in diabetic rats. Administration of Curcumin Copper Oxide Nano-Composite in diabetic rats caused significant improvement of all previous parameters. These results suggested that, Curcumin Copper Oxide Nano-Composite treatment may decrease the diabetic complications as hyperglycemia and oxidative stress in rats through free radical scavenging as well as regulation of endogenous antioxidant defense system mechanisms.

show abstract

“…One of the best known antipyrine derivatives is 4‐aminoantipyrine (4‐amino‐2,3‐dimethyl‐1‐phenyl‐3‐pyrazolin‐5‐one), which presents a structural similarity with metamizole, a well‐known and very effective analgesic, anti‐inflammatory agent . In continuation of our research program directed towards synthesis and investigation of biologically active compounds . It seems therefore to be of considerable interest to synthesize novel aminopyrazole, pyrazolo [1,5‐ a ] pyrimidine, bispyrazole and bispyridone derivatives containing antipyrinyl moiety.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Antimicrobial Activity and Molecular Modeling of Some Novel 5‐Aminopyrazole, Pyrazolo[1,5‐a]pyrimidine, Bispyrazole and Bispyridone Derivatives Containing Antipyrinyl Moiety

Helal

Salem

Aly

2017

Journal of Heterocyclic Chem

View full text Add to dashboard Cite

2‐Cyano‐N‐(antipyrin‐4‐yl)‐3‐(ethylthio)‐3‐(naphthalen‐1‐ylamino)acryl‐amide 4 was achieved via a one‐pot, three‐component reactions of cyanoacetamide derivative 2, 2‐naphthyl isothiocyanate, and diethyl‐sulphate. The cyano acrylamide derivative 4 was hydrazinolysis to furnish 5‐aminopyrazole 5; many pyrazolo[1,5‐a]pyrimidines 10a,b, 14, 15, 16, 18, and 20 have been synthesized via treatment of 5 with some electrophilic reagents. Also, ternary condensation of cyanoacetamide derivative 2, terephthalaldehyde, and active methylene derivatives afforded bispyridone derivatives 21a,b. The structures of the new compounds were confirmed on the basis of elemental analysis and spectral data. Representative compounds of the synthesized products were tested and evaluated as antimicrobial. In general, the novel‐synthesized compounds showed a good antimicrobial activity against Gram‐positive bacteria, Gram‐negative bacteria, and antifungal activity against Azithromycin and Ketoconazole. The molecular modeling of the 21a and 21b as representative examples of the synthesized compounds has been drawn, and their molecular parameters were calculated.

show abstract

Solution Coordination Chemistry of Organotin(IV) Cations with Bio-relevant Ligands

Cited by 15 publications

References 105 publications

Supramolecular Assemblies Based on Complexes of Nonionic Amphiphilic Cyclodextrins and a meso-Tetra(4-sulfonatophenyl)porphine Tributyltin(IV) Derivative: Potential Nanotherapeutics against Melanoma

Supramolecular Assemblies Based on Complexes of Nonionic Amphiphilic Cyclodextrins and a meso-Tetra(4-sulfonatophenyl)porphine Tributyltin(IV) Derivative: Potential Nanotherapeutics against Melanoma

Biochemical study on the potential therapeutic use of novel curcumin copper oxide nanocomposite in diabetic complications in rats

Synthesis, Antimicrobial Activity and Molecular Modeling of Some Novel 5‐Aminopyrazole, Pyrazolo[1,5‐a]pyrimidine, Bispyrazole and Bispyridone Derivatives Containing Antipyrinyl Moiety

Contact Info

Product

Resources

About