Solution NMR investigations of integral membrane proteins: Challenges and innovations

Necelis, Matthew; McDermott, Connor; Belcher Dufrisne, Meagan; Baryiames, Christopher; Columbus, Linda

doi:10.1016/j.sbi.2023.102654

Current Opinion in Structural Biology

2023

DOI: 10.1016/j.sbi.2023.102654

|View full text |Cite

Solution NMR investigations of integral membrane proteins: Challenges and innovations

Matthew Necelis,

Connor McDermott,

Meagan Belcher Dufrisne

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article2

Relationship

Self Cite0

Independent2

Authors

Journals

Cited by 2 publications

References 106 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Future opportunities in solute carrier structural biology

Newstead

2024

Nat Struct Mol Biol

View full text Add to dashboard Cite

Future opportunities in solute carrier structural biology

Newstead

2024

Nat Struct Mol Biol

View full text Add to dashboard Cite

Influence of Lipid Conformations on the Interaction Energy between a Membrane and a Peripheral Protein

Volynsky,

Alekseeva,

Boldyrev

2024

Jetp Lett.

View full text Add to dashboard Cite

Peripheral membrane proteins are temporarily coupled to the surface of a membrane, penetrating into the lipid layer. In this work, it has been shown that the fraction of trans configurations of dihedral angles in hydrophobic chains of lipids decreases in the region of contact of peripheral membrane proteins with the membrane. This effect differs for different lipid chains and for dihedral angles at different distances from the beginning of a chain. A gosh configuration has a higher energy than a trans configuration. Consequently, the decrease in the fraction of trans configurations leads to an increase in the energy of the chain. The energy of chain conformations for the peripheral membrane protein considered in this work increases by ≈2 kJ/mol. A chain in chain conformations is involved in molecular mechanisms determining the elastic modulus of membranes. The energy stored in a conformation chain can be spent to the desorption of protein from the surface of the membrane and can be considered as a reason why the interaction of peripheral membrane proteins with the membrane is temporal.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Solution NMR investigations of integral membrane proteins: Challenges and innovations

Cited by 2 publications

References 106 publications

Future opportunities in solute carrier structural biology

Future opportunities in solute carrier structural biology

Influence of Lipid Conformations on the Interaction Energy between a Membrane and a Peripheral Protein

Contact Info

Product

Resources

About