In this paper, we will introduce a well-known transformation technique, the modified α-fractional differential transform, to the differential equation of fractional order. We derive some new results with proof using new techniques that never existed before. By using this new technique, we are attempting to solve the nonlinear fractional-order mathematical epidemic model. Furthermore, the fractional epidemic model’s solution obtained by using this new technique is correlated with the solution of the same model calculated for a different fractional order by the modified α-fractional differential transform method. Moreover, using the Python software, we can numerically and graphically represent the solution of fractional differential equations.