2007
DOI: 10.1002/chin.200719150
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Solution‐Phase Synthesis and Preliminary Evaluation of 1,6,8‐Trisubstituted Tetrahydro‐2H‐pyrazino[1,2‐a]pyrimidin‐4,7‐dione Derivatives as a NF‐kB Inhibitor.

Abstract: Pyrazine derivatives R 0550 Solution-Phase Synthesis and Preliminary Evaluation of 1,6,8-Trisubstituted Tetrahydro-2H-pyrazino[1,2-a]pyrimidin-4,7-dione Derivatives as a NF-kBInhibitor. -Compounds (VIIIb) and (VIIIc) exhibit a 40% inhibition of the target NF-kB 549 [for compound (V) no yield given]. -(KIM, J.-W.; LEE, S.-C.; PARK, H. B.; JO, N. H.; YOO, K. H.; CHO, J.-H.; OH*, C.-H.; Bull. Korean Chem.

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