Solvation effects and reactivity of free pyridine residues in macromolecules of poly-4-vinylpyridine derivatives

Starodubtzev, Sergei G.; Kirsh, Yu. E.; Kabanov, V.A.

doi:10.1016/0014-3057(74)90189-x

Cited by 52 publications

(15 citation statements)

References 10 publications

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“…S7 in the Supporting Information) in accordance with empirical Eq. (1) which is quite close to the equation describing spectral properties of PEVP [13]:…”

Section: Ftir Spectramentioning

confidence: 76%

“…Thus in spectrum of PEVP which was prepared by exhaustive alkylation of parent polymer PVP with ethyl bromide a narrow distinct peak at 1643 cm À1 related to alkylated pyridinium groups is presented. In FTIR spectrum of parent PVP this peak is not found, but instead the pronounced peak at 1597 cm À1 corresponding to non-charged pyridine groups [13] is observed (Fig. 3a).…”

Section: Ftir Spectramentioning

confidence: 85%

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Supercharged pyridinium polycations and polyelectrolyte complexes

Izumrudov

Zhiryakova

Melik‐Nubarov

2015

European Polymer Journal

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“…S7 in the Supporting Information) in accordance with empirical Eq. (1) which is quite close to the equation describing spectral properties of PEVP [13]:…”

Section: Ftir Spectramentioning

confidence: 76%

Section: Ftir Spectramentioning

confidence: 85%

Supercharged pyridinium polycations and polyelectrolyte complexes

Izumrudov

Zhiryakova

Melik‐Nubarov

2015

European Polymer Journal

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“…C2PVPS (Pw = 18 and 500) and C16PVP (Pm = 400) were obtained by alkylation of corresponding PVP fractions with cetyl and/or ethyl bromides according to the procedure previously described (21). The degree of PVP alkylation was determined by IR spectroscopy (21).…”

Section: Introductionmentioning

confidence: 99%

Efficient transformation of mammalian cells using DNA interpolyelectrolyte complexes with carbon chain polycations

et al. 1993

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A new method for mammalian cell transformation is proposed which is based on incorporation of plasmids into interpolyelectrolyte complexes (IPECs) with carbon chain polycations. The method is illustrated by examples of pRSV CAT and p beta-Gal plasmid IPECs with poly(N-ethyl-4-vinylpyridinium bromide) (C2PVP) and poly(N-ethyl-4-vinylpyridinium)-poly(N-cetyl-4-vinylpyridinium+ ++) bromides random copolymer (C16PVP). These IPECs are produced spontaneously due to formation of a cooperative system of interchain electrostatic bonds after mixing DNA and polycation solutions. The interaction of IPEC with normal mouse fibroblasts NIH 3T3, human T-lymphoma "Jurkat", and Mardin Darby canine kidney cells has been studied. The data obtained has revealed that plasmid incorporation into IPECs significantly enhances both DNA adsorption on the plasma membrane and DNA uptake into a cell. The in vitro transformation of NIH 3T3 cells was monitored by a standard cloramphenicol acetyltransferase (CAT) assay (pRSV CAT plasmid) and by detection of beta-galactosidase (beta-Gal) expression using 4-methylumbeliferril beta-D-galactopyranoside as a substrate (p beta-Gal plasmid). In both cases it has been proved that IPEC-incorporated plasmids possess an ability for efficient cell transformation. The transforming activity of IPECs depends on their composition and polycation chemical structure. Under optimal conditions the efficiency of cell transformation with IPECs is several fold higher than that observed during standard calcium phosphate precipitation. The mechanism of the phenomenon observed is discussed.(ABSTRACT TRUNCATED AT 250 WORDS)

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“…A more recent reappraisal study shows that the catalytic activity of the free pyridine residue in partly quaternized polyvinylpyridines is similar to or lower than that of ethylpyridine 2 in the PNPA sotvolysis (90). Rate enhancements were observed for NABA 4 because of the electrostatic attraction.…”

Section: Catalysis By Vinyl Polymers Containing Nucleophiles Other Than Imidazole 5--1 Polyvinylpyridine and Polyvinyltriazolementioning

confidence: 99%

Catalytic hydrolysis by synthetic polymers

Kunitake

Okahata

New Scientific Aspects

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Solvation effects and reactivity of free pyridine residues in macromolecules of poly-4-vinylpyridine derivatives

Cited by 52 publications

References 10 publications

Supercharged pyridinium polycations and polyelectrolyte complexes

Supercharged pyridinium polycations and polyelectrolyte complexes

Efficient transformation of mammalian cells using DNA interpolyelectrolyte complexes with carbon chain polycations

Catalytic hydrolysis by synthetic polymers

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