Solvent Adaptive Dynamic Metal‐Organic Soft Hybrid for Imaging and Biological Delivery

Abstract

As olvent responsive dynamic nanoscale metalorganic framework (NMOF) [Zn(1a)(H 2 O) 2 ]h as been devised based on the self-assembly of Zn II and asymmetric bola-amphiphilic oligo-(p-phenyleneethynylene) (OPE) dicarboxylate linker 1a having dodecyl and triethyleneglycolmonomethylether (TEG,p olar) side chains.I nT HF solvent, NMOF showed nanovesicular morphology (NMOF-1)w ith surface decorated dodecyl chains.I nw ater and methanol, NMOF exhibited inverse-nanovesicle (NMOF-2)a nd nanoscroll (NMOF-3)m orphology,r espectively,w ith surface projected TEG chains.The pre-formed NMOFs also unveiled reversible solvent responsive transformation of different morphologies.T he flexible NMOF showed cyan emission and no cytotoxicity,a llowing live cell imaging.C isplatin (14.4 wt %) and doxorubicin (4.1 wt %) were encapsulated in NMOF-1 by non-covalent interactions and, in vitro and in vivo drug release was studied. The drug loaded NMOFs exhibited micromolar cytotoxicity.

Photo-modulated wide-spectrum chromism in Eu3+ and Eu3+/Tb3+ photochromic coordination polymer gels: application in decoding secret information

“…This exclusive photoinduced reversible morphology transformation from spheres to bers could enable the use of such materials in the domains of photoactuators 4,39 and delivery media. 45,68 Next, a rheology study was performed for Eu-pcCPG-O and Eu-pcCPG-C, which showed the viscoelastic nature of both the photoisomers of pcCPG. Notably, G 0 for both Eu-pcCPG-O and Eu-pcCPG-C was found to be similar under less % strain, which decreases along with an increase in the % strain.…”

A Portrait of the OPE as a Biological Agent

“…The possibility of using OPE derivatives for dual imaging and drug-carrying systems represents a goal for many scientists. In 2019, Maji et al [ 28 ] developed a metal organic hybrid system for imaging and drug delivery that is based on functionalized OPEs possessing solvent-adaptive behavior. These oligomers form a nanoscale metal organic framework (NMOF) with different morphologies, depending on the solvent ( Figure 3 a).…”

A “Thermodynamically Stable” 2D Nickel Metal–Organic Framework over a Wide pH Range with Scalable Preparation for Efficient C2s over C1 Hydrocarbon Separations

“…Metal–organic frameworks (MOFs) are documented as one of the most significant classes of porous materials due to their distinctive features and versatility . However, the development of water‐stable MOFs still remains a great challenge for applications, in terms of five major areas—adsorption and/or separation, sensing, catalysis, drug delivery, and proton conduction—where such applications are conducted in water‐containing environments .…”