2011
DOI: 10.1007/s10953-010-9641-7
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Solvent Effects on the Structure-Property Relationship of Some Potentially Pharmacologically Active 3-(4-Substituted Benzyl)-5-Ethyl-5-Phenyl- and 3-(4-Substituted Benzyl)-5,5-Diphenylhydantoins

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Cited by 7 publications
(4 citation statements)
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“…Specific solute-solvent interactions were subdivided into solvent Lewis-basicity interactions (hydrogen bond donor (HBD) solute/ /(hydrogen bond acceptor (HBA) solvents) and solvent Lewis acidity interactions (hydrogen bond acceptor (HBA) solute/(hydrogen bond donor (HBD) solvents). Thus, the following multiparameter equation was suggested for application in linear solvation energy relationships (LSER): [26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44] LSER have been used in various fields, such as, ionic liquids, solubility, thermochemistry, NMR chemical shifts, pharmaceuticals, etc. Equation (10) has been used in the correlation analysis by multiple regression of numerous reaction rates and equilibria, spectroscopic data and various other solvent dependent processes.…”
Section: Application Of the Kat Model For The Study Of The Solvent Efmentioning
confidence: 99%
“…Specific solute-solvent interactions were subdivided into solvent Lewis-basicity interactions (hydrogen bond donor (HBD) solute/ /(hydrogen bond acceptor (HBA) solvents) and solvent Lewis acidity interactions (hydrogen bond acceptor (HBA) solute/(hydrogen bond donor (HBD) solvents). Thus, the following multiparameter equation was suggested for application in linear solvation energy relationships (LSER): [26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44] LSER have been used in various fields, such as, ionic liquids, solubility, thermochemistry, NMR chemical shifts, pharmaceuticals, etc. Equation (10) has been used in the correlation analysis by multiple regression of numerous reaction rates and equilibria, spectroscopic data and various other solvent dependent processes.…”
Section: Application Of the Kat Model For The Study Of The Solvent Efmentioning
confidence: 99%
“…Proučavajući antiproliferativnu aktivnost 3-(4-supstituisanih benzil)-5,5-difenilhidantoina i 3-(4-supstituisanih benzil)-5-etil-5-fenilhidantoina, Ušćumlić i saradnici su pokazali značajnu aktivnost ovih molekula prema ćelijskoj liniji humanog karcinoma dojke, MDA--MB-231 i ćelijskoj liniji humanog karcinoma kolona HCT-116. Aktivnost je naročito izražena kada se na fenilnom jezgru kao supstituenti nalaze metil-grupa i halogeni elementi [39][40][41][42].…”
Section: Antiproliferativna Aktivnost Derivata Spirohidantoinaunclassified
“…Poupaert et al tested a limited series of compounds structurally related to phenytoin and observed that the anticonvulsant activity decreased with a reduction in their ability to form hydrogen bonds. [12][13][14] Since most drug candidates fail in preclinical and clinical trials because of their unfavourable ADME (absorption, distribution, metabolism and excretion) properties, ADME modelling has attracted significant attention over the last two decades. 10,11 In this context, it was proposed that the structure-activity and structure-property relationships of hydantoin anticonvulsants have molecular size and hydrogen bonding as their primary determinants.…”
Section: Introductionmentioning
confidence: 99%