2023
DOI: 10.1021/acs.analchem.2c04949
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Solvent Effects Used for Optimal Simultaneous Analysis of Amino Acids via 19F NMR Spectroscopy

Abstract: 19 F NMR has been extensively used in simultaneous analysis of multicomponent due to its 100% natural isotope abundance, high NMR-sensitivity, and wide-range chemical shifts. The solvent effects are usually observed in NMR spectroscopy and cause large changes in 19 F chemical shifts. Herein, we propose that the simultaneous analysis of a complex mixture can be achieved using solvent effects via 19 F NMR spectroscopy, such as a mixture solution of amino acids (AAs). AAs are not only cell-signaling molecules, bu… Show more

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Cited by 9 publications
(4 citation statements)
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“…Generally, the concentration will also have a certain effect on the 1 H NMR chemical shift, acting mainly on changes in solution viscosity, changes in ion pairs, or changes in aggregation states. 27 In this work, six different concentrations of FFC solutions in DMSO- d 6 (20, 50, 100, 150, 200, 250 mmol/L) were used to further investigate the influence of concentrations on the 1 H NMR chemical shifts of FFC; however, no dramatical changes were found ( Fig. 3 ).…”
Section: Resultsmentioning
confidence: 97%
“…Generally, the concentration will also have a certain effect on the 1 H NMR chemical shift, acting mainly on changes in solution viscosity, changes in ion pairs, or changes in aggregation states. 27 In this work, six different concentrations of FFC solutions in DMSO- d 6 (20, 50, 100, 150, 200, 250 mmol/L) were used to further investigate the influence of concentrations on the 1 H NMR chemical shifts of FFC; however, no dramatical changes were found ( Fig. 3 ).…”
Section: Resultsmentioning
confidence: 97%
“…This presents a significant obstacle when applying 19 F NMR analysis to biological samples. Despite the existence of several F-labeling protocols for amines and alcohols, they have not yet been fully optimized for metabolite analysis. …”
Section: Introductionmentioning
confidence: 99%
“…Various 19 F-labeled chiral derivatizing agents have been developed, facilitating the chiral discrimination of a wide range of analytes containing amino or hydroxy groups. 9 As an alternative to covalent derivatization, 19 F-labeled probes capable of reversibly binding to the analyte have been explored. When the chemical exchange rate is slow on the NMR timescale, distinct 19 F NMR signals corresponding to each enantiomer are produced.…”
mentioning
confidence: 99%